Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma
ConclusionSulfatides were found in tumor tissue of patients with iCCA, with sulfatide abundance per pixel being similar to bile ducts. In this explorative study, sulfatide abundance was not related to overall survival of iCCA patients. A high ratio of unsaturated to saturated sulfatides was associated with earlier tumor recurrence in patients with iCCA. (Source: Cellular Oncology)
Source: Cellular Oncology - January 11, 2023 Category: Cancer & Oncology Source Type: research
Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts
ConclusionsTaken together, these data revealed a mechanism by which ACACA downregulation directed the formation of an immunosuppressive lung PMN in breast cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - January 6, 2023 Category: Cancer & Oncology Source Type: research
The Breast Cancer Single-Cell Atlas: Defining cellular heterogeneity within model cell lines and primary tumors to inform disease subtype, stemness, and treatment options
ConclusionThe BSCLA defines the heterogeneity within BC cell lines, enhancing our overall understanding of BC cellular diversity to guide future BC research, including model cell line selection, unintended sample source effects, stemness factors between cell lines, and cell type-specific treatment response. (Source: Cellular Oncology)
Source: Cellular Oncology - January 4, 2023 Category: Cancer & Oncology Source Type: research
Reciprocal FGF19-GLI2 signaling induces epithelial-to-mesenchymal transition to promote lung squamous cell carcinoma metastasis
ConclusionOur data suggest that FGF19 may serve as a novel biomarker for predicting metastatic LUSC. Intervening with the FGF19-GLI2 feedback loop may be a strategy for the treatment of FGF19-driven LUSC metastasis. (Source: Cellular Oncology)
Source: Cellular Oncology - January 4, 2023 Category: Cancer & Oncology Source Type: research
Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions
ConclusionsIn general, our research presented PRM1 as a specific CRC antigen and illustrated the importance of PRM1 in CRC metabolism rewiring. The new vulnerability of CRC cells was also provided with the potential to be targeted in future.Graphical abstractDiagnostic value and grow factor-like biofunction of PRM1 A represents the secretion process of PRM1 regulated by nutrient deficiency. B represents activation of PI3K/AKT/mTOR pathway of secreted PRM1. (Source: Cellular Oncology)
Source: Cellular Oncology - January 3, 2023 Category: Cancer & Oncology Source Type: research
Ezrin accelerates breast cancer liver metastasis through promoting furin-like convertase-mediated cleavage of Notch1
ConclusionOur results demonstrated that ezrin drives BCLM through activation of the Notch signaling pathway via furin-like convertase. These findings provide a better understanding of the mechanism of ezrin in breast cancer progression, with the goal of discovering a novel target for the treatment of BCLM in the future. (Source: Cellular Oncology)
Source: Cellular Oncology - December 29, 2022 Category: Cancer & Oncology Source Type: research
Retraction Note: The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer
(Source: Cellular Oncology)
Source: Cellular Oncology - December 29, 2022 Category: Cancer & Oncology Source Type: research
H3K27 acetylation activated long noncoding RNA RP11-162G10.5 promotes breast cancer progression via the YBX1/GLO1 axis
ConclusionsOur findings suggest that the histone modification-activated lncRNA contributes to the oncogenesis of BC. Also, our data reveal a role for RP11-162G10.5 in BC tumorigenesis and may supply a strategy for targeting the RP11-162G10.5 as a potential biomarker and a therapeutic target for breast cancer patients. (Source: Cellular Oncology)
Source: Cellular Oncology - December 28, 2022 Category: Cancer & Oncology Source Type: research
Correction to: IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF- κB signaling to promote colorectal cancer progression
(Source: Cellular Oncology)
Source: Cellular Oncology - December 27, 2022 Category: Cancer & Oncology Source Type: research
Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization
ConclusionThe tumor microenvironment in malignant astrocytoma, exhibits changes in cell composition, cell signaling activation and extracellular matrix deposition during disease development and that targeting the extracellular matrix, as well as cell signaling activation will be critical to designing personalized therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - December 26, 2022 Category: Cancer & Oncology Source Type: research
WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma
ConclusionsThese data implicate WNT5A-ROR2 in VEGF secretion, vascularity, adverse outcomes and bevacizumab sensitivity of BRAFMut melanomas, suggesting that this axis has potential therapeutic relevance. (Source: Cellular Oncology)
Source: Cellular Oncology - December 21, 2022 Category: Cancer & Oncology Source Type: research
Establishment of experimental salivary gland cancer models using organoid culture and patient-derived xenografting
ConclusionWe report the generation of SGC PDOs, PDXs and PDXOs of multiple histological subtypes, recapitulating the histological and genetical characteristics of the original tumors. These experimental SGC models may serve as a useful resource for the development of novel therapeutic strategies and for investigating the molecular mechanisms underlying the development of these malignancies. (Source: Cellular Oncology)
Source: Cellular Oncology - December 20, 2022 Category: Cancer & Oncology Source Type: research
Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity
ConclusionOur findings provide new insight into the mechanism by which ARHGEF12 regulates neuroblastoma tumorigenicity and suggest a translatable therapeutic approach by targeting ARHGEF12 with a small molecular inhibitor. (Source: Cellular Oncology)
Source: Cellular Oncology - December 15, 2022 Category: Cancer & Oncology Source Type: research
TRIM44 regulates tumor immunity in gastric cancer through LOXL2-dependent extracellular matrix remodeling
ConclusionThese findings demonstrate that TRIM44 regulates the stability of LOXL2 to remodel the tumor extracellular matrix to modulate tumor immunity in gastric cancer and that the TRIM44/LOXL2 complex is a promising biomarker for gastric cancer prognosis and might be a novel immunotherapy target. (Source: Cellular Oncology)
Source: Cellular Oncology - December 13, 2022 Category: Cancer & Oncology Source Type: research
YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m6A-mediated YWHAZ stability
ConclusionOur findings reveal a critical role of YBX1 in maintaining survival of CML LSCs, which provides a rationale for targeting YBX1 in CML treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - December 13, 2022 Category: Cancer & Oncology Source Type: research
