Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy
ConclusionIn this review, we first summarized the origins, classifications and general lipid metabolic process of TAMs. Then we discussed the currently available drugs and interventions that target lipid metabolic disorders of TAMs, including those targeting lipid uptake, efflux, lipolysis, FAO and lipid peroxidation. Besides, based on the recent research status, we summarized the present challenges for this cancer immunotherapy, including the precise drug delivery system, the lipid metabolic heterogeneity, and the intricate lipid metabolic interactions in the TME, and we also proposed corresponding possible solutions. Col...
Source: Cellular Oncology - September 30, 2023 Category: Cancer & Oncology Source Type: research
Endothelial-derived small extracellular vesicles support B-cell acute lymphoblastic leukemia development
ConclusionIn summary, our findings indicate that the secretion of ANGPTL2-containing SEVs in ECs sustains the leukemogenic activities of B-ALL cells, which is fine-tuned by the direct interaction of VPS33B and ANGPTL2. These findings reveal that niche-specific SEVs play an important role in B-ALL development.Graphical abstract (Source: Cellular Oncology)
Source: Cellular Oncology - September 26, 2023 Category: Cancer & Oncology Source Type: research
Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway
ConclusionOur findings confer a comprehensive and mechanistic function of Notum in GC tumor sphere formation and tumorigenesis that may provide a novel and promising target for early diagnosis and clinical therapy of GC. (Source: Cellular Oncology)
Source: Cellular Oncology - September 26, 2023 Category: Cancer & Oncology Source Type: research
Immune characteristics associated with lymph node metastasis in early-stage NSCLC
ConclusionsOur data indicate that LN metastasis facilitated tumor-specific antigen presentation in TDLNs and induces T cell priming, while existing tumor cells generate an immune-suppressive environment in MPLNs through multiple mechanisms. These findings contribute to a comprehensive understanding of the immunological mechanisms through which LN metastasis influences tumor progression and plays a role in immunotherapy for NSCLC patients. (Source: Cellular Oncology)
Source: Cellular Oncology - September 20, 2023 Category: Cancer & Oncology Source Type: research
From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment
ConclusionFAP's intricate interactions with tumor cells and the tumor microenvironment make it a promising target for diagnosis and treatment. Promising strategies such as FAPI offer potential avenues for accurate tumor diagnosis, while multiple therapeutic strategies highlight the prospects of FAP targeting treatments which needs further clinical evaluation. (Source: Cellular Oncology)
Source: Cellular Oncology - September 19, 2023 Category: Cancer & Oncology Source Type: research
Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies
AbstractExcessive fibrosis is a predominant feature of pancreatic stroma and plays a crucial role in the development and progression of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Emerging evidence showed diversity and heterogeneity of fibroblasts play crucial and somewhat contradictory roles, the interactions between fibroblasts and pancreatic cells or infiltrating immune cells are of great importance during PDAC and CP progression, with some promising therapeutic strategies being tested. Therefore, in this review, we describe the classification of fibroblasts and their functions in PDAC and pan...
Source: Cellular Oncology - September 18, 2023 Category: Cancer & Oncology Source Type: research
Ferritinophagy induced ferroptosis in the management of cancer
ConclusionThis review delineates the regulatory mechanism of ferritinophagy firstly and summarizes the role of ferritinophagy-induced ferroptosis in cancer. Moreover, the strategies targeting ferritinophagy to induce ferroptosis are highlighted to unveil the therapeutic value of ferritinophagy as a target to manage cancer. Finally, the future research directions on how to cope with the challenges in developing ferritinophagy promoters into clinical therapeutics are discussed.Graphical abstract (Source: Cellular Oncology)
Source: Cellular Oncology - September 15, 2023 Category: Cancer & Oncology Source Type: research
Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway
ConclusionsUbiquilin-4 may contribute to immune escape in gastric cancer by upregulating programmed death ligand 1 expression in tumor cells through Notch signaling activation. Thus, ubiquilin-4 could serve as a predictive marker for programmed death ligand 1 inhibitor therapy response in gastric cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - September 13, 2023 Category: Cancer & Oncology Source Type: research
Synergistic antitumor efficacy of gemcitabine and cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via Sp1-SAT1-polyamine metabolism pathway
ConclusionsIn summary, our findings suggested the gemcitabine and cisplatin combination therapy induced ferroptosis in a GSH-independent manner in PDAC. The combined treatment inhibited Sp1 and upregulated SAT1 transcription, leading to the breakdown of spermine and spermidine. Therefore, targeting SAT1-induced polyamine metabolism may represent a promising therapeutic strategy for PDAC. (Source: Cellular Oncology)
Source: Cellular Oncology - September 9, 2023 Category: Cancer & Oncology Source Type: research
Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
ConclusionNiche-derived growth factors drive MAPK activity and MCL1 expression in osteosarcoma, promoting metastatic colonization. Although later metastases produce less MCL1, they remain dependent on it. MCL1 is a promising target for clinical trials in both human and canine patients. (Source: Cellular Oncology)
Source: Cellular Oncology - September 7, 2023 Category: Cancer & Oncology Source Type: research
ATM-Mediated translocation of RanBPM regulates DNA damage response by stabilizing p21 in non-small cell lung cancer cells
ConclusionRanBPM is a novel regulator of P21 protein stability, and plays a critical role in the regulation of DDR. (Source: Cellular Oncology)
Source: Cellular Oncology - September 7, 2023 Category: Cancer & Oncology Source Type: research
Overexpressed FAM111B degrades GSDMA to promote esophageal cancer tumorigenesis and cisplatin resistance
ConclusionsOverall, we identified a novel FAM111B/GSDMA axis regulating ESCA tumorigenesis and chemosensitivity, at least in ESCC cells. (Source: Cellular Oncology)
Source: Cellular Oncology - September 6, 2023 Category: Cancer & Oncology Source Type: research
SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer
ConclusionSAMHD1 expression is a novel prognostic biomarker in early breast cancer that impacts immune-mediated signaling and differentially regulates inflammatory intra-tumoral response. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2023 Category: Cancer & Oncology Source Type: research
Vimentin promotes glioma progression and maintains glioma cell resistance to oxidative phosphorylation inhibition
ConclusionsIn conclusion, we comprehensively deciphered the role of VIM in the progression of glioma and its clinical outcomes. Thus provide new insights into targeting VIM in glioma cancer immunotherapy in combination with the current treatment.Graphical abstract (Source: Cellular Oncology)
Source: Cellular Oncology - August 30, 2023 Category: Cancer & Oncology Source Type: research
Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesity
ConclusionObese adipocytes trigger aggressive transformation in PDAC cells to induce PDAC progression and accelerate angiogenesis via OPN secretion. (Source: Cellular Oncology)
Source: Cellular Oncology - August 29, 2023 Category: Cancer & Oncology Source Type: research
