Importance of CD45RO+ tumor-infiltrating lymphocytes in post-operative survival of breast cancer patients
ConclusionFrom our data we conclude that CD45RO+ TILs serve as prognostic factors for predicting OS and DFS of breast cancer patients. (Source: Cellular Oncology)
Source: Cellular Oncology - March 1, 2019 Category: Cancer & Oncology Source Type: research

Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma – MCT1 as potential target in diffuse large B cell lymphoma
ConclusionsOur results indicate that elevated glycolytic activity is associated with NHL aggressiveness, pointing at metabolic cooperation, mediated by MCT1 and MCT4, between tumour cells and their surrounding stroma. MCT1 may serve as a target to treat NHL (diffuse large B cell lymphoma) patients with high MCT1/low MCT4 expressing tumours. Further (pre-)clinical studies are required to allow the design of novel therapeutic strategies aimed at e.g. reprogramming the tumour microenvironment. (Source: Cellular Oncology)
Source: Cellular Oncology - February 21, 2019 Category: Cancer & Oncology Source Type: research

Inhibition of MEK suppresses hepatocellular carcinoma growth through independent MYC and BIM regulation
ConclusionsCollectively, our data indicate that trametinib exhibits efficacy in treating HCC cells via distinct regulation of the MYC and BIM pathways. As such, targeting MEK to block MAPK signaling with trametinib may provide novel treatment opportunities for HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - February 20, 2019 Category: Cancer & Oncology Source Type: research

The X-linked inhibitor of apoptosis protein (XIAP) is involved in melanoma invasion by regulating cell migration and survival
ConclusionFrom our data we conclude that XIAP acts as a multifunctional pro-metastatic protein in skin melanomas and, as a consequence, that XIAP may serve as a therapeutic target for these melanomas. (Source: Cellular Oncology)
Source: Cellular Oncology - February 18, 2019 Category: Cancer & Oncology Source Type: research

Secretome profiling of heterotypic spheroids suggests a role of fibroblasts in HIF-1 pathway modulation and colorectal cancer photodynamic resistance
ConclusionCollectively, our results delineate a potential mechanism by which stromal fibroblasts may enhance colorectal cancer cell survival and photodynamic treatment resistance via HIF-1 pathway modulation. (Source: Cellular Oncology)
Source: Cellular Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

Antitumor effect of XCT790, an ERR α inverse agonist, on ERα-negative endometrial cancer cells
AbstractPurposeThe estrogen-related receptor (ERR) α is structurally similar to classical estrogen receptors (ERs), but is considered to be an orphan nuclear receptor. We previously found that ERRα regulates uterine endometrial cancer progression. Here, we investigated the efficacy of XCT790, a selective inverse agonist of ERRα, on endometrial ca ncer cells in vitro and in vivo.MethodsHEC-1A and KLE, ER α-negative endometrial cancer cells exhibiting high ERRα expression levels, and HEC-1A cell-derived xenograft model mice were treated with XCT790. Transcriptional activity and cell proliferatio...
Source: Cellular Oncology - January 31, 2019 Category: Cancer & Oncology Source Type: research

Recombinant cell-permeable HOXA9 protein inhibits NSCLC cell migration and invasion
ConclusionsOur data suggest that the developed cell-permeable R10-HOXA9 system may serve as a useful tool to prevent NSCLC cell migration and invasion. (Source: Cellular Oncology)
Source: Cellular Oncology - January 29, 2019 Category: Cancer & Oncology Source Type: research

Nuclear localization of PD-L1: artifact or reality?
ConclusionWe propose that well-specified and rigorously followed protocols should be applied to immunocytochemical diagnostic techniques, especially to those related to individualized diagnosis and treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - January 25, 2019 Category: Cancer & Oncology Source Type: research

Concomitant dysregulation of the estrogen receptor and BRAF/MEK signaling pathways is common in colorectal cancer and predicts a worse prognosis
AbstractPurposeRecurrence is a major cause of colorectal cancer (CRC)-related death. As yet, the accurate identification of CRC patients at high risk of recurrence is still a major clinical challenge. Previously, we found that an estrogen receptor (ER) pathway gene signature may predict disease recurrence in CRC patients. The aim of this study is to evaluate the potential application of additional pathway-specific gene signatures in the prediction of CRC recurrence.MethodsThe activities of 26 cancer-related pathways in CRC were semi-quantified using gene signature-based Bayesian binary regression analysis, and putative ass...
Source: Cellular Oncology - January 15, 2019 Category: Cancer & Oncology Source Type: research

MicroRNA-mediated redox regulation modulates therapy resistance in cancer cells: clinical perspectives
ConclusionsHere, we summarize current knowledge on microRNA-mediated redox regulatory mechanisms underlying chemo/radio-resistance. This knowledge may form a basis for a better clinical management of cancer patients. (Source: Cellular Oncology)
Source: Cellular Oncology - January 15, 2019 Category: Cancer & Oncology Source Type: research

Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation
ConclusionOur data indicate that Nectin-4 may play a prominent role in 5-FU resistance of metastatic CC cells and that NQC sensitizes these cells by Nectin-4 deregulation through ADAM-17 inhibition, a major component of the NOTCH signalling pathway. (Source: Cellular Oncology)
Source: Cellular Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma
ConclusionsOur findings indicate that bromodomain-mediated gene regulation constitutes an epigenetic mechanism that is deregulated in MEC cells and that the use of BET inhibitors may serve as a feasible therapeutic strategy to manage MECs. (Source: Cellular Oncology)
Source: Cellular Oncology - December 11, 2018 Category: Cancer & Oncology Source Type: research

CCR5 blockage by maraviroc: a potential therapeutic option for metastatic breast cancer
ConclusionOur findings indicate that targeting CCR5 may be an effective strategy to combat breast cancer bone metastasis. (Source: Cellular Oncology)
Source: Cellular Oncology - November 19, 2018 Category: Cancer & Oncology Source Type: research

Therapeutic targeting potential of chromatin-associated proteins in MLL -rearranged acute leukemia
ConclusionsHere, we review chromatin-associated proteins fundamental toMLLr AL development, highlighting those with targeting potential by small molecule inhibitors. In particular, we focus on synthetic targeting of multiple chromatin-associated proteins, a strategy that shows superior therapeutic efficacy and offers hope for overcoming drug resistance. (Source: Cellular Oncology)
Source: Cellular Oncology - November 16, 2018 Category: Cancer & Oncology Source Type: research

Cell-free DNA in cancer: current insights
ConclusionsIn this review we discuss the biology, recent advancements, technical considerations and clinical implications of ctDNA in the context of cancer, and highlight important challenges and future directions for the integration of ctDNA into standardised patient care. (Source: Cellular Oncology)
Source: Cellular Oncology - October 26, 2018 Category: Cancer & Oncology Source Type: research

Molecular features unique to glioblastoma radiation resistant residual cells may affect patient outcome - a short report
ConclusionsOur data indicate that molecular features of innately radiation resistant GBM cells independently correlate with clinical outcome. Our study also highlights the relevance of using patient-derived primary GBM cultures for the characterization of RR cells that are otherwise inaccessible for analysis. (Source: Cellular Oncology)
Source: Cellular Oncology - October 26, 2018 Category: Cancer & Oncology Source Type: research

Long non-coding RNAs as monitoring tools and therapeutic targets in breast cancer
ConclusionsIn this review, we discuss the potential application of lncRNAs for the monitoring and treatment of breast cancer. We conclude that lncRNAs play important roles in the pathophysiology of this disease and may serve as putative therapeutic targets. As such, tumor-specific lncRNAs may be instrumental for improving current breast cancer clinical practices. (Source: Cellular Oncology)
Source: Cellular Oncology - October 25, 2018 Category: Cancer & Oncology Source Type: research

CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer
ConclusionsOur findings contribute to our understanding of the role of chronic inflammation in GBC development and progression, and may offer potential therapeutic targets for GBC. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms
ConclusionsFrom our data we conclude that the S100A8 and S100A9 granulocyte and plasma levels are increased in MPN patients, along with inflammation markers, depending on theirJAK2V617F mutation allele burden. We also found that S100A8/9-mediated inhibition of the proliferation-related AKT and ERK1/2 signaling pathways can be decreased byCALR mutation-dependent TLR4 blocking and increased by RAGE inhibition in MPN. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation
ConclusionsOur data reveal a dual mode of action of STF-31, serving either as a NAMPT or as a GLUT inhibitor, whereby the latter seems to be apparent only at higher STF-31 concentrations. The molecular basis of such a dual function and its appearance in compounds previously designated as NAMPT-specific inhibitors requires further investigation. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells
ConclusionThe antagonistic effects of Inositol-C2-PAF on cell migration and proliferation are indicative for its potential for breast cancer therapy, alone or in combination with other cytostatic drugs. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

β-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells
ConclusionsFrom our data we conclude that the extent ofCTNNB1 gene promoter methylation by reactive oxygen species correlates with the migratory and invasive abilities of colon cancer cells. Our results suggest that epigenetic regulation ofCTNNB1 may serve as a novel avenue to block colon cancer cell migration and invasion. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Identification of an enhancer region within the TP63 / LEPREL1 locus containing genetic variants associated with bladder cancer risk
ConclusionsTaken together, our data show that bladder cancer risk-associated variants on chromosome 3q28 are located in an active enhancer region. Further characterization of the allele-specific activity of the identified enhancer and its target genes may lead to the identification of novel signaling pathways involved in bladder carcinogenesis. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
ConclusionsOur data suggest that lung and liver cancers require efficient single-strand break repair for their growth in order to benefit from a low aldehyde detoxification metabolism. We also propose that the ratio of XRCC1 and ALDH2 levels may serve as a useful prognostic tool in these cancer types. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression
ConclusionsIn addition to controlling mitochondrial biogenesis NRF1, in conjunction with E2F4 and MYC, may play a critical role in the acquisition of human cancer characteristics. Additionally, NRF1 may orchestrate both MYC and E2F4 to regulate common target genes linked to multiple networks in the development and progression of cancer. A comprehensive understanding of this dynamic interplay will set the stage, not only for the design of novel treatment strategies, but also for the discovery of pan-cellular transcription factor regulatory strategies to predict cancer risk, therapy response and patient prognosis. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Stromal collagen type VI associates with features of malignancy and predicts poor prognosis in salivary gland cancer
AbstractPurposeCollagen Type VI (COLVI) is an extracellular matrix protein that is upregulated in various solid tumours during tumour progression and has been shown to stimulate proliferation, suppress apoptosis and promote invasion and metastasis. It has also been described as a mediator of chemotherapy resistance and as a therapeutic target in preclinical cancer models. Here, we aimed to analyse the prognostic role of COLVI in salivary gland cancer (SGC).MethodsStromal COLVI protein expression was assessed in primary SGC specimens of 91 patients using immunohistochemistry (IHC). The IHC expression patterns obtained were ...
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Mesenchymal marker and LGR5 expression levels in circulating tumor cells correlate with colorectal cancer prognosis
AbstractPurposeThe presence of circulating tumor cells (CTCs) has been found to correlate with colorectal cancer (CRC) prognosis, whereas epithelial-mesenchymal transition (EMT) in CTCs has been found to be associated with CRC metastasis. LGR5 is a known target of Wnt signaling and plays an important role in CRC development. The aim of this study was to assess the clinical relevance of EMT and LGR5 expression in CTCs from CRC patients.MethodsSixty-six CRC patients were included in this study. The detection and expression of EMT phenotypes in CTCs from these patients were assessed using CanPatrol ™ CTC enrichment and ...
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

CCL18 secreted from M2 macrophages promotes migration and invasion via the PI3K/Akt pathway in gallbladder cancer
ConclusionsOur findings contribute to our understanding of the role of chronic inflammation in GBC development and progression, and may offer potential therapeutic targets for GBC. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Correction to: β-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells
In the original version of above mentioned article an error occurred in Fig.  2. Panel g and panel h are included in the figure legend, but have not been published in the figure. (Source: Cellular Oncology)
Source: Cellular Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Emerging ways to treat breast cancer: will promises be met?
ConclusionsPotential new strategies that are designed to specifically target BC are presented. Several clinical trials using these strategies are already in progress and have shown promising results, but inherent limitations such as off-target effects and low delivery efficiencies still have to be resolved. By improving the clinical efficacy of current therapies and exploring new ones, it is anticipated that novel ways to overcome BC may become attainable. (Source: Cellular Oncology)
Source: Cellular Oncology - September 27, 2018 Category: Cancer & Oncology Source Type: research

S100P and Ezrin promote trans-endothelial migration of triple negative breast cancer cells
ConclusionsFrom our data we conclude that S100P, Ezrin and EzrinThr-567 are involved in the trans-endothelial migration of TNBC cells and that they may serve as potential targets in TNBC patients. (Source: Cellular Oncology)
Source: Cellular Oncology - September 22, 2018 Category: Cancer & Oncology Source Type: research

Novel tumor suppressor SPRYD4 inhibits tumor progression in hepatocellular carcinoma by inducing apoptotic cell death
ConclusionsOur data indicate that a decreased SPRYD4 expression may serve as an independent predictor for a poor prognosis in patients with HCC and that increased SPRYD4 expression may reduce HCC growth and progression through the induction of apoptotic cell death, thereby providing a potential therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - September 20, 2018 Category: Cancer & Oncology Source Type: research

The emerging role of lncRNAs in the regulation of cancer stem cells
ConclusionslncRNAs are valuable tools in the search for new targets to selectively eliminate CSCs and improve clinical outcomes. LncRNAs may serve as excellent therapeutic targets because they are stable, easily detectable and expressed in tissue-specific contexts. (Source: Cellular Oncology)
Source: Cellular Oncology - September 14, 2018 Category: Cancer & Oncology Source Type: research

Epigenetic markers in basal cell carcinoma: universal themes in oncogenesis and tumor stratification? - a short report
ConclusionsOur data reveal an EZH2-associated epigenetic marker profile that correlates with histologic signs of BCC aggressiveness. Our findings may have diagnostic and therapeutic implications, and indicate that epigenetic markers may be shared even with relatively less aggressive tumor types, thereby suggesting universal themes. (Source: Cellular Oncology)
Source: Cellular Oncology - September 13, 2018 Category: Cancer & Oncology Source Type: research

SOX3 can promote the malignant behavior of glioblastoma cells
ConclusionFrom our data we conclude that SOX3 can promote the malignant behavior of glioblastoma cells. (Source: Cellular Oncology)
Source: Cellular Oncology - September 12, 2018 Category: Cancer & Oncology Source Type: research

In silico screening for ER α down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells
ConclusionsWe suggest that modulation of the intracellular ER α concentration in BC cells can be exploited in in silico screens to identify anti-BC drugs and uncover a re-purposing opportunity for thioridazine in the treatment of primary and metastatic ET resistant BCs. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Radio-sensitization of head and neck cancer cells by a combination of poly(I:C) and cisplatin through downregulation of survivin and c-IAP2
ConclusionsOur results indicate that a combined poly(I:C) and cisplatin treatment reduces the survival and induces the radio-sensitivity of HNSCC-derived cells, thus providing a rationale for the development of novel strategies for the treatment of head and neck cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

CXCL12 expression is a bona fide predictor of recurrence in lung neuroendocrine tumours; a multicentric study with emphasis on atypical carcinoids  - a short report
ConclusionCXCL12 immunohistochemistry may serve as a potentially useful tool to better stratify LNETs, and more specifically ACs, in clinical practice. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

In silico screening for ER α down modulators identifies thioridazine as an anti-proliferative agent in primary, 4OH-tamoxifen-resistant and Y537S ERα-expressing breast cancer cells
ConclusionsWe suggest that modulation of the intracellular ER α concentration in BC cells can be exploited in in silico screens to identify anti-BC drugs and uncover a re-purposing opportunity for thioridazine in the treatment of primary and metastatic ET resistant BCs. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Radio-sensitization of head and neck cancer cells by a combination of poly(I:C) and cisplatin through downregulation of survivin and c-IAP2
ConclusionsOur results indicate that a combined poly(I:C) and cisplatin treatment reduces the survival and induces the radio-sensitivity of HNSCC-derived cells, thus providing a rationale for the development of novel strategies for the treatment of head and neck cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

CXCL12 expression is a bona fide predictor of recurrence in lung neuroendocrine tumours; a multicentric study with emphasis on atypical carcinoids  - a short report
ConclusionCXCL12 immunohistochemistry may serve as a potentially useful tool to better stratify LNETs, and more specifically ACs, in clinical practice. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Anti-tumor effect of CDK inhibitors on CDKN2A -defective squamous cell lung cancer cells
ConclusionOur data suggest a potential role of CDK inhibitors in managingCDKN2A-defective SqCLC. (Source: Cellular Oncology)
Source: Cellular Oncology - September 3, 2018 Category: Cancer & Oncology Source Type: research

Drug-induced expression of EpCAM contributes to therapy resistance in esophageal adenocarcinoma
ConclusionsFrom our data we conclude that an ACF-induced increase in EpCAM expression reflects the selection of a CSC subpopulation that underlies tumor development and drug resistance in EAC. (Source: Cellular Oncology)
Source: Cellular Oncology - August 16, 2018 Category: Cancer & Oncology Source Type: research

Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones
ConclusionsOur data indicate that the cytotoxic activity of P1 and P2 on leukemia/lymphoma cells is mediated by proteasome inhibition, leading to activation of pro-apoptotic pathways. (Source: Cellular Oncology)
Source: Cellular Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research