Osteopontin secreted from obese adipocytes enhances angiogenesis and promotes progression of pancreatic ductal adenocarcinoma in obesity
ConclusionObese adipocytes trigger aggressive transformation in PDAC cells to induce PDAC progression and accelerate angiogenesis via OPN secretion. (Source: Cellular Oncology)
Source: Cellular Oncology - August 29, 2023 Category: Cancer & Oncology Source Type: research
tRNA-derived fragments: mechanism of gene regulation and clinical application in lung cancer
This article primarily examines the mechanisms by which tRFs modulate gene expression and contribute to tumorigenesis in lung cancer. Furthermore, we provide a comprehensive overview of the current bioinformatics analysis of tRFs in lung cancer, with the objective of offering a systematic and efficient approach for studying the expression profiling, functional enrichment, and molecular mechanisms of tRFs in this disease. Finally, we discuss the clinical significance and potential avenues for future research on tRFs in lung cancer. This paper presents a comprehensive systematic review of the existing research findings on tR...
Source: Cellular Oncology - August 29, 2023 Category: Cancer & Oncology Source Type: research
Integrative proteomics and n-glycoproteomics reveal the synergistic anti-tumor effects of aspirin- and gemcitabine-based chemotherapy on pancreatic cancer cells
ConclusionsIn-depth analysis of N-glycosylation-related processes and pathways in pancreatic cancer cells can provide new insight for future studies regarding pancreatic cancer therapeutic targets and drug resistance mechanisms. (Source: Cellular Oncology)
Source: Cellular Oncology - August 28, 2023 Category: Cancer & Oncology Source Type: research
Targeting PUF60 prevents tumor progression by retarding mRNA decay of oxidative phosphorylation in ovarian cancer
ConclusionOur study unveils a novel function of PUF60 in OC energy metabolism. Thus, PUF60 may serve as a novel target for the treatment of patients with OC. (Source: Cellular Oncology)
Source: Cellular Oncology - August 26, 2023 Category: Cancer & Oncology Source Type: research
Single-cell transcriptomic profiling reveals immune cell heterogeneity in acute myeloid leukaemia peripheral blood mononuclear cells after chemotherapy
ConclusionOur results elucidated the PBMC single-cell landscape and provided insights into precision medicine and immunotherapy for treating AML. (Source: Cellular Oncology)
Source: Cellular Oncology - August 24, 2023 Category: Cancer & Oncology Source Type: research
Triggering pyroptosis enhances the antitumor efficacy of PARP inhibitors in prostate cancer
ConclusionOur findings highlight a novel therapeutic strategy for enhancing the long-term response to olaparib beyond HRR-deficient tumors in PCa, underscoring the critical role of GSDME in regulating tumorigenesis. (Source: Cellular Oncology)
Source: Cellular Oncology - August 23, 2023 Category: Cancer & Oncology Source Type: research
Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance
ConclusionThis review elucidates the clinical significance of PNI, summarizes the underlying cellular and molecular mechanisms, introduces various experimental models suitable for studying PNI, and discusses the therapeutic potential of targeting this phenomenon. By delving into the intricate interactions between nerves and tumor cells, we hope this review can provide valuable insights for the future development of CRC treatments. (Source: Cellular Oncology)
Source: Cellular Oncology - August 23, 2023 Category: Cancer & Oncology Source Type: research
CircGLIS3 inhibits thyroid cancer invasion and metastasis through miR-146b-3p/AIF1L axis
ConclusionOur study identified circGLIS3 as a novel tumor suppressor in thyroid cancer, indicating the potential of circGLIS3 as a promising diagnostic and prognostic marker for thyroid cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - August 23, 2023 Category: Cancer & Oncology Source Type: research
Lactate score classification of hepatocellular carcinoma helps identify patients with tumors that respond to immune checkpoint blockade therapy
ConclusionIn the current study, we developed a classification system for HCC and defined the lactate score, which was validated to be partially effective in estimating responses among tumor patients. (Source: Cellular Oncology)
Source: Cellular Oncology - August 23, 2023 Category: Cancer & Oncology Source Type: research
Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
ConclusionIn conclusion, with proficientRB1,MYCN-induced high level ofE2F expression dysregulates the cell cycle and contributes to retinoblastoma carcinogenesis. The increased level of E2f renders the cells to adopt a similar mechanistic phenotype to aRB1-deficient tumour. (Source: Cellular Oncology)
Source: Cellular Oncology - August 22, 2023 Category: Cancer & Oncology Source Type: research
Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer
ConclusionsOur study reveals a previous unprecedented regulatory role of ONECUT3 in PDAC glycolysis and provides in vivo evidence that increased glycolysis is linked to an immunosuppressive microenvironment. Moreover, targeting ONECUT3-PDK1 axis may serve as a promising therapeutic approach for the treatment of PDAC. (Source: Cellular Oncology)
Source: Cellular Oncology - August 22, 2023 Category: Cancer & Oncology Source Type: research
Prognostic significance of collagen signatures at breast tumor boundary obtained by combining multiphoton imaging and imaging analysis
ConclusionThis standardized and automated imaging prognosticator may convince pathologists to adopt it as a prognostic factor, thereby customizing more effective treatment plans for patients. (Source: Cellular Oncology)
Source: Cellular Oncology - August 22, 2023 Category: Cancer & Oncology Source Type: research
Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancer
ConclusionTogether, our results demonstrate that the suppressive function of RACK1 in GC is associated with ASCT2-mediated glutamine metabolism, and imply that targeting RACK1/ASCT2 axis provides potential strategies for GC treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - August 14, 2023 Category: Cancer & Oncology Source Type: research
Survivin degradation by bergenin overcomes pemetrexed resistance
ConclusionsSurvivin overexpression is required for maintaining multiple malignant phenotypes of NSCLC cells. Bergenin exerts a potent antitumor effect on NSCLC via targeting survivin, rendering it a promising agent for the treatment of NSCLC. (Source: Cellular Oncology)
Source: Cellular Oncology - August 5, 2023 Category: Cancer & Oncology Source Type: research
Immunosuppressive MFAP2+ cancer associated fibroblasts conferred unfavorable prognosis and therapeutic resistance in gastric cancer
ConclusionImmunosuppressive MFAP2+ CAFs constructed an immune evasive tumor microenvironment characterized by incapacitated immune effector cells, consequently predicting inferior clinical outcomes and response on adjuvant therapy and immunotherapy in patients with GC. The potential of immunosuppressive MFAP2+ CAFs as a therapeutic target for GC deserved thoroughly exploration. (Source: Cellular Oncology)
Source: Cellular Oncology - August 4, 2023 Category: Cancer & Oncology Source Type: research
