Targeting nucleolin improves sensitivity to chemotherapy in acute lymphoblastic leukemia
ConclusionOur results highlight NCL as a prognostic marker in B-ALL and a potential therapeutic target to combat chemotherapy resistance in ALL. (Source: Cellular Oncology)
Source: Cellular Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
ConclusionThis review summarized those studies from three perspectives (SNPs, mutation, and expression level) and listed the relationship between biomarkers and therapeutic effect, highlighting the great potential of predictive molecular biomarkers in metastatic RCC therapy. However, due to a series of reasons, most of these findings require further validation. (Source: Cellular Oncology)
Source: Cellular Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research
miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
ConclusionOur work identifies a valuable oncogene, miR-4739, that accelerates malignant progression in “driver gene-negative” NSCLC and serves as a potential therapeutic target for this group of tumors. (Source: Cellular Oncology)
Source: Cellular Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
ConclusionOur findings demonstrate that TRIM24 is critical for NB differentiation and suggest that TRIM24 is a promising therapeutic target in combination with RA in NB differentiation therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research
TGF- β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
ConclusionOur study describes a “self-rescue” mechanism of CD8+ T cells in HCC against exhaustion and the good effects from amplifying this signal. (Source: Cellular Oncology)
Source: Cellular Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research
HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
ConclusionOur study demonstrates that PiwiL1 act as an oncogene in cervical cancer by inducing tumor-associated properties and EMT pathway. The finding that HPV oncogenes, E6/E7 can positively regulate PiwiL1 suggests a possible mechanism behind HPV-mediated tumorigenesis in cervical cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - December 1, 2023 Category: Cancer & Oncology Source Type: research
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
ConclusionsOur findings suggest that stiff matrix induces expression of pro-metastatic and neurotrophic genes through integrin β1-FAK-YAP signals, which finally facilitates PNI in BRCA. Thus, our study provides a new mechanism for PNI in BRCA and highlights nerve-based tumor treatment strategies. (Source: Cellular Oncology)
Source: Cellular Oncology - November 28, 2023 Category: Cancer & Oncology Source Type: research
CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
ConclusionAltogether, these results illustrated the essential role of CAD in GBM and revealed a novel therapeutic strategy for CAD-positive and CHIP-negative cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - November 20, 2023 Category: Cancer & Oncology Source Type: research
TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
ConclusionsOur findings underscore a clinically relevant role for TIPRL1 and its ATM-dependent phosphorylation in RT resistance through modulation of the DDR, highlighting its potential as a new HNSCC predictive marker and therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - November 16, 2023 Category: Cancer & Oncology Source Type: research
Silencing AHNAK promotes nasopharyngeal carcinoma progression by upregulating the ANXA2 protein
ConclusionHere, we report AHNAK as a tumor suppressor in NPC, which may act through annexin A2 oncogenic signaling in enlargeosome, with potential implications for novel approaches to NPC treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - November 14, 2023 Category: Cancer & Oncology Source Type: research
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer
ConclusionsTogether these data unreveal a previously unregnized regulatory mechanism of FGFR4 by LIF/LIFR and demonstrate that LIF and FGF19 converge on the regulation of oncogenic STAT3 in GC cells.Graphical abstract (Source: Cellular Oncology)
Source: Cellular Oncology - November 9, 2023 Category: Cancer & Oncology Source Type: research
Exploration of molecular markers related to chemotherapy efficacy of hepatoid adenocarcinoma of the stomach
ConclusionChemotherapy is closely associated with changes in the molecular characteristics of HAS. After chemotherapy, at genomic and transcriptome level, many features were altered. These changes may be molecular markers of poor chemotherapeutic efficacy and play an important role in chemoresistance in HAS. In addition,ERBB2,FGFR2,MET andHGF gene amplification may be potential therapeutic targets for HAS. (Source: Cellular Oncology)
Source: Cellular Oncology - November 9, 2023 Category: Cancer & Oncology Source Type: research
Complexation of histone deacetylase inhibitor belinostat to Cu(II) prevents premature metabolic inactivation in vitro and demonstrates potent anti-cancer activity in vitro and ex vivo in colon cancer
ConclusionsComplexation of belinostat to Cu(II) does not alter the HDAC activity of belinostat, but instead significantly enhances its metabolic stabilityin vitro and targets anti-cancer pathways by perturbing key MRs in colon cancer. Complexation of HDACis to a metal ion might improve the efficacy of clinically used HDACis in patients with colon cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - November 7, 2023 Category: Cancer & Oncology Source Type: research
Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and drug resistance by activating oncogenic SRC and downstream signaling pathways
ConclusionCT45A1 promotes cervical cancer cell tumorigenesis, neovascularization, and drug resistance by activating oncogenic SRC and downstream tumorigenic signaling pathways. These findings provide new insight into the pathogenesis of cervical cancer and offer a new platform for the development of novel therapeutics against cervical cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - November 4, 2023 Category: Cancer & Oncology Source Type: research
E3 ligase SOCS3 regulates NOD2 expression by ubiquitin proteasome system in lung cancer progression
ConclusionCollectively, our work reveals novel roles of SOCS3 in lung tumorigenesis and proposes SOCS3 as a promising biomarker candidate for therapeutic and diagnostic target for lung cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - November 1, 2023 Category: Cancer & Oncology Source Type: research
