Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer
ConclusionOur results show that high densities of CXCR4 and pCXCR4 positive TICs are favorable prognostic factors in CRC. (Source: Cellular Oncology)
Source: Cellular Oncology - September 21, 2017 Category: Cancer & Oncology Source Type: research

Expression of inflammatory lipopolysaccharide binding protein (LBP) predicts the progression of conventional renal cell carcinoma - a short report
AbstractBackgroundThe mortality of conventional renal cell carcinoma (RCC) correlates directly with the presence or postoperative development of metastases. The aim of this study was to identify new markers associated with the postoperative progression of conventional RCC.MethodsTissue microarrays (TMA) of conventional RCC from a cohort of 414 patients were analysed by immunohistochemistry for expression of the lipopolysaccharide binding protein (LBP), which was identified as a candidate biomarker through Affymetrix U133 Plus 2.0 array analysis. Univariate and multivariate Cox regression models were addressed to cancer-spe...
Source: Cellular Oncology - September 21, 2017 Category: Cancer & Oncology Source Type: research

Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer
ConclusionsDespite their similarities, the expression levels and functions of AKR1B1 and AKR1B10 are highly divergent in CRC, and they may have prognostic implications. (Source: Cellular Oncology)
Source: Cellular Oncology - September 19, 2017 Category: Cancer & Oncology Source Type: research

Glucosidase II beta subunit (GluII β) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner
ConclusionsOur data indicate that GluII β inhibition results in autophagy and apoptosis in lung carcinoma-derived cells, supporting the hypothesis that this enzyme may play a role in blocking these two tumor suppressive processes. Since blocking autophagy by lysosomal inhibitors enhanced the apoptosis-inducing effect of bromoconduritol, independent of p53 status, their combined use may hold promise for the treatment of cancer, particularly lung cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - September 19, 2017 Category: Cancer & Oncology Source Type: research

Lung cancer-associated brain metastasis: Molecular mechanisms and therapeutic options
ConclusionsThe identification of molecular mechanisms underlying lung cancer metastasis has opened up new avenues towards their eradication and provides interesting opportunities for future research aimed at the development of novel targeted therapies. (Source: Cellular Oncology)
Source: Cellular Oncology - September 18, 2017 Category: Cancer & Oncology Source Type: research

Differential effect of TGF β on the proteome of cancer associated fibroblasts and cancer epithelial cells in a co-culture approach - a short report
ConclusionsFrom our data we conclude that CAFs respond to TGF β treatment by changing their proteome composition, while ETCs appear to be rather resilient. (Source: Cellular Oncology)
Source: Cellular Oncology - August 14, 2017 Category: Cancer & Oncology Source Type: research

Increased EGFR expression induced by a novel oncogene, CUG2, confers resistance to doxorubicin through Stat1-HDAC4 signaling
ConclusionTaken together, we conclude that CUG2-induced EGFR upregulation confers doxorubicin resistance to lung (cancer) cells through Stat1-HDAC4 signaling. (Source: Cellular Oncology)
Source: Cellular Oncology - August 3, 2017 Category: Cancer & Oncology Source Type: research

Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2
ConclusionsOur data indicate that leptin may enhance the proliferation, migration and invasion of breast cancer cells viaACAT2 up-regulation through the PI3K/AKT/SREBP2 signaling pathway. Therefore, the leptin/ACAT2 axis may represent an attractive therapeutic target for breast cancer, particularly in postmenopausal and/or obese women. (Source: Cellular Oncology)
Source: Cellular Oncology - August 2, 2017 Category: Cancer & Oncology Source Type: research

A step-by-step microRNA guide to cancer development and metastasis
ConclusionsThe impact and the dynamic potential of miRNAs with oncogenic or tumor suppressor properties in each stage of the multistep process of tumorigenesis, and in the adaptation of cancer cells to stress, are discussed. We propose that the balance between oncogenic versus tumor suppressive miRNAs acting within transcription factor-miRNA regulatory networks, influences both the multistage process of neoplastic transformation, whereby normal cells become cancerous, and their stress responses. The role of specific tumor-derived exosomes containing miRNAs and their use as biomarkers in diagnosis and prognosis, and as ther...
Source: Cellular Oncology - July 26, 2017 Category: Cancer & Oncology Source Type: research

Digital droplet PCR (ddPCR) for the detection and quantification of HPV 16, 18, 33 and 45  - a short report
ConclusionsSeparation of fragments in nanodroplets may facilitate the amplification of fragmented human and viral DNA. The method of digital droplet PCR may, thus, provide a new and promising tool for evaluating the HPV viral load in clinical samples. (Source: Cellular Oncology)
Source: Cellular Oncology - July 26, 2017 Category: Cancer & Oncology Source Type: research

MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1 α/VEGF signaling axis in breast cancer cells
ConclusionsOverall, our findings suggest that exosomal transfer of miR-100 may be a novel mechanism underlying the paracrine effects of MSC-derived exosomes and may provide a means by which these vesicles can modulate vascular responses within the microenvironment of breast cancer cells. (Source: Cellular Oncology)
Source: Cellular Oncology - July 24, 2017 Category: Cancer & Oncology Source Type: research

EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells
ConclusionsOur findings suggest that EphA3 plays an important role in the pathogenesis of MM and provide support for the notion that its targeting may represent a novel therapeutic opportunity for MM. (Source: Cellular Oncology)
Source: Cellular Oncology - July 18, 2017 Category: Cancer & Oncology Source Type: research

Suppression of a cancer stem-like phenotype mediated by alpha-lipoic acid in human lung cancer cells through down-regulation of β-catenin and Oct-4
ConclusionOur data are indicative for a novel regulatory role and underlying mechanism of LA in the negative regulation of a CSC-like phenotype in non-small cell lung cancer-derived cells. (Source: Cellular Oncology)
Source: Cellular Oncology - July 4, 2017 Category: Cancer & Oncology Source Type: research

ΔNp73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report
ConclusionsOur data support a role for ΔNp73 in the multidrug-resistance of breast cancer and melanoma cells. (Source: Cellular Oncology)
Source: Cellular Oncology - July 4, 2017 Category: Cancer & Oncology Source Type: research

Progesterone suppresses the invasion and migration of breast cancer cells irrespective of their progesterone receptor status - a short report
ConclusionOur results indicate that progesterone can inhibit breast cancer cell invasion and migration mediated by the de-phosphorylation of kinases. This inhibition appears to be independent of the PR status of the breast cancer cells. In a broader context, our study may provide a basis for an association between progesterone treatment and recurrence reduction in breast cancer patients, thereby providing a lead for modelling a randomized in vitro study. (Source: Cellular Oncology)
Source: Cellular Oncology - June 26, 2017 Category: Cancer & Oncology Source Type: research

Histamine H 4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis  - a short report
ConclusionsOur results suggest an association between H4R and oral carcinogenesis. Furthermore, our findings raise a potential implication of histamine-mediated factors in the regulation of oncogenes, possibly via mast cells, as crucial components of the tumor microenvironment. The identification of new elements that govern oral cancer development is highly relevant for the development of novel therapeutic approaches in OTSCC. (Source: Cellular Oncology)
Source: Cellular Oncology - June 26, 2017 Category: Cancer & Oncology Source Type: research

Crosstalk between M2 macrophages and glioma stem cells
ConclusionsOur data indicate that the co-culture of CSCs and macrophages results in bi-directional signaling that alters the phenotypes of both cell types. These results provide an explanation for recently observed effects of macrophages on GBM tumor cell growth, motility and therapeutic resistance, and suggest potential therapeutic strategies to disrupt the CSC phenotype by impairing its communication with macrophages. (Source: Cellular Oncology)
Source: Cellular Oncology - June 22, 2017 Category: Cancer & Oncology Source Type: research

Changes in plasma miR-9, miR-16, miR-205 and miR-486 levels after non-small cell lung cancer resection
ConclusionsOur data indicate that miR-9, miR-16, miR-205 and miR-486 may serve as NSCLC biomarkers. The observed cancer-related pre- and post-operative changes in their plasma levels may not only reflect the presence of a primary cancer, but also of a systemic response to cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - June 20, 2017 Category: Cancer & Oncology Source Type: research

Association between epidermal growth factor receptor amplification and ADP-ribosylation factor 1 methylation in human glioblastoma
ConclusionsThe results reported here provide a basis for a new hypotheses connectingEGFR gene amplification in GB cells withARF1 gene promoter methylation, vesicle trafficking, membrane turnover and tumor metabolism. The mechanism(s) underlying these connections and their functional consequences remain to be established. (Source: Cellular Oncology)
Source: Cellular Oncology - June 19, 2017 Category: Cancer & Oncology Source Type: research

Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/ β-catenin axis in hepatocellular carcinoma
ConclusionsOur current data substantiate our knowledge on the role of CDH17 in the biology of HCC and suggest that components of the CDH17/ β-catenin axis may serve as therapeutic targets in CDH17 over-expressing HCC patients. (Source: Cellular Oncology)
Source: Cellular Oncology - June 19, 2017 Category: Cancer & Oncology Source Type: research

microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients
ConclusionsThe ampTSmiR test is more sensitive than the conventional TGCC protein biomarkers for the detection of residual disease and relapse, excluding mature teratoma. (Source: Cellular Oncology)
Source: Cellular Oncology - June 13, 2017 Category: Cancer & Oncology Source Type: research

The role of hERG1 ion channels in epithelial-mesenchymal transition and the capacity of riluzole to reduce cisplatin resistance in colorectal cancer cells
ConclusionsOur data indicate that hERG1 plays a role in the EMT of colorectal cancer cells and that its knockdown reduces the proliferative and tumorigenic capacities of these cells. In addition, we conclude that riluzole may be used in combination with cisplatin to reduce chemo-resistance in colorectal cancer cells. (Source: Cellular Oncology)
Source: Cellular Oncology - June 7, 2017 Category: Cancer & Oncology Source Type: research

Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples – a short report
ConclusionMCAM-based flow cytometric analysis of pleural effusions is more sensitive than routine cytological analysis. Flow cytometric analysis of pleural effusions and tumor-associated CECs in peripheral blood may serve as a promising approach for the prognostication of MPM patients and, therefore, warrants further study. (Source: Cellular Oncology)
Source: Cellular Oncology - June 2, 2017 Category: Cancer & Oncology Source Type: research

MDMX is a prognostic factor for non-small cell lung cancer and regulates its sensitivity to cisplatin
ConclusionsOur data indicate that MDMX expression may serve as an independent unfavorable prognostic factor for NSCLC patient outcome, which in turn may at least partly be due to the ability of the MDMX protein to regulate the proliferative capacity and chemosensitivity of NSCLC cells. (Source: Cellular Oncology)
Source: Cellular Oncology - May 31, 2017 Category: Cancer & Oncology Source Type: research

Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours
AbstractBackgroundTesticular germ cell tumours (TGCT) are highly sensitive to cisplatin-based chemotherapy, but patients with tumours containing differentiated teratoma components are less responsive to this treatment. The cisplatin sensitivity in TGCT has previously been linked to the embryonic phenotype in the majority of tumours, although the underlying mechanism largely remains to be elucidated. The aim of this study was to investigate the role of the DNA mismatch repair (MMR) system in the cisplatin sensitivity of TGCT.MethodsThe expression pattern of key MMR proteins, including MSH2, MSH6, MLH1 and PMS2, were investi...
Source: Cellular Oncology - May 23, 2017 Category: Cancer & Oncology Source Type: research

Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1
ConclusionsThis study focuses on recent progress on the role of VCAM-1, an important glycoprotein belonging  to the immunoglobulin (Ig) superfamily of cell surface adhesion molecules in breast cancer angiogenesis, survival and metastasis. Targeting VCAM-1, expressed on the surface of breast cancer cells, and/or its specific ligand VLA-4/α4β1 integrin, expressed on cells at the site of metastasis, may b e a useful strategy to reduce breast cancer cell invasion and metastasis. Various approaches to therapeutically target VCAM-1 and VLA-4 are also discussed. (Source: Cellular Oncology)
Source: Cellular Oncology - May 22, 2017 Category: Cancer & Oncology Source Type: research

Synthetic lethal targeting of RNF20 through PARP1 silencing and inhibition
ConclusionsCollectively, our data indicate thatRNF20 andPARP1 are synthetic lethal interactors, suggesting that cancers with diminished RNF20 expression and/or function may be susceptible to PARP1 inhibitors. (Source: Cellular Oncology)
Source: Cellular Oncology - May 1, 2017 Category: Cancer & Oncology Source Type: research

Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells
ConclusionsOur current results suggest that the application of HDACi in combination with drugs that target DNMT may represent a promising option for the treatment of medulloblastoma. (Source: Cellular Oncology)
Source: Cellular Oncology - April 20, 2017 Category: Cancer & Oncology Source Type: research

Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition
ConclusionFrom our results we conclude that dual treatment with SHK and TMZ may constitute a powerful new tool for GBM treatment by reducing therapy resistance and tumor recurrence. (Source: Cellular Oncology)
Source: Cellular Oncology - April 11, 2017 Category: Cancer & Oncology Source Type: research

Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascade
ConclusionsTaken together, we conclude that ERK1/2 signaling pathway inhibition by silymarin and silibinin increases the expression of the pro-apoptotic Bcl-2 family member Bim which, subsequently, induces mitochondria-mediated apoptosis in salivary gland cancer-derived cells. (Source: Cellular Oncology)
Source: Cellular Oncology - April 11, 2017 Category: Cancer & Oncology Source Type: research

Integrative transcriptome analysis of liver cancer profiles identifies upstream regulators and clinical significance of ACSM3 gene expression
ConclusionOur data provide evidence for a differential expression and regulation of theACSM3 gene in HCC, and may lay a foundation for therapeutically targeting fatty acid metabolism in these tumors. (Source: Cellular Oncology)
Source: Cellular Oncology - April 7, 2017 Category: Cancer & Oncology Source Type: research

Emetine induces estrogen receptor alpha degradation and prevents 17 β-estradiol-induced breast cancer cell proliferation
(Source: Cellular Oncology)
Source: Cellular Oncology - March 29, 2017 Category: Cancer & Oncology Source Type: research

Tumor cells interact with red blood cells via galectin-4 - a short report
AbstractBackgroundThe ability of tumor cells to invade and metastasize is relevant to the process of cancer progression and, as such, it represents an obstacle to cancer cure. So far, limited information is available on interactions between circulating tumor cells and blood cells. It is well-documented that galectin-4 is upregulated in many types of tumor cells and is involved in metastasis. Here, we address the hypothesis that tumor cells may interact with red blood cells (RBCs) via galectin-4.MethodsHigh galectin-4 expressing colon, normal pancreatic and pancreatic cancer-derived cell lines (n = 5) were incubat...
Source: Cellular Oncology - March 14, 2017 Category: Cancer & Oncology Source Type: research

Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss
ConclusionsInhibition of CDK4 by palbociclib can enhance paclitaxel sensitivity in both Rb-positive and Rb-negative MDR ovarian cancer cells by increasing apoptosis. CDK4 may serve as a promising target in the treatment of ovarian cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - February 27, 2017 Category: Cancer & Oncology Source Type: research

Identification of candidate miRNA biomarkers for pancreatic ductal adenocarcinoma by weighted gene co-expression network analysis
ConclusionsWe identified several miRNAs critical for PDAC development using WGCNA. These miRNAs may serve as biomarkers for PDAC diagnosis/prognosis and patient stratification, and as putative novel therapeutic targets. (Source: Cellular Oncology)
Source: Cellular Oncology - February 15, 2017 Category: Cancer & Oncology Source Type: research

Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells
ConclusionsFrom our results we conclude that both VPA and TSA can induce pancreatic cancer cell apoptosis and autophagy. VPA appears have a stronger and broader cytotoxic effect than TSA and, thus, may represent a better choice for anti-pancreatic cancer therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - February 3, 2017 Category: Cancer & Oncology Source Type: research

Epigenetic sampling effects: nephrectomy modifies the clear cell renal cell cancer methylome
ConclusionTissue ischaemia during normal surgical removal of tumour can cause epigenetic changes. Based on these results, we conclude that the impact of sampling procedures in clinical epigenetic studies should be considered and discussed, particularly after inducing hypoxia/ischaemia, which occurs in most oncological surgery procedures through which tissues are collected for translational research. (Source: Cellular Oncology)
Source: Cellular Oncology - January 10, 2017 Category: Cancer & Oncology Source Type: research

microRNA-761 induces aggressive phenotypes in triple-negative breast cancer cells by repressing TRIM29 expression
ConclusionsOur data indicate that miR-761 acts as an oncogene in TNBC. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29. We suggest that miR-761 may serve as a promising therapeutic target for TNBC. (Source: Cellular Oncology)
Source: Cellular Oncology - January 4, 2017 Category: Cancer & Oncology Source Type: research

CDKN2A-p53 mediated antitumor effect of Lupeol in head and neck cancer
ConclusionTogether, our data indicate that Lupeol may orchestrate a bifurcated regulation of neoplastic growth and apoptosis in head and neck cancers and may serve as a promising agent for the management of tumors that have progressed on a platinum-based treatment regimen. (Source: Cellular Oncology)
Source: Cellular Oncology - December 30, 2016 Category: Cancer & Oncology Source Type: research

HPIP promotes epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer cells through PI3K/AKT pathway activation
ConclusionsFrom these results we conclude that HPIP expression is associated with high-grade ovarian tumors and may promote their migration, invasion and EMT, a process that is associated with metastasis. In addition, we conclude that HPIP may serve as a potential therapeutic target for cisplatin resistant ovarian tumors. (Source: Cellular Oncology)
Source: Cellular Oncology - December 30, 2016 Category: Cancer & Oncology Source Type: research

ELMO3 expression indicates a poor prognosis in head and neck squamous cell carcinoma - a short report
ConclusionOur data indicate that in the surgically treated and postoperatively irradiated patients tested, ELMO3 expression serves as a predictive marker for reduced survival. (Source: Cellular Oncology)
Source: Cellular Oncology - December 30, 2016 Category: Cancer & Oncology Source Type: research

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer
ConclusionsMulti-biomarker panels accompanied by a meticulous determination of their sensitivity and specificity, as well their validation, using multivariate analyses will be critical for its clinical application, including early OC detection and tailor-made OC treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - December 15, 2016 Category: Cancer & Oncology Source Type: research

microRNA-145 modulates epithelial-mesenchymal transition and suppresses proliferation, migration and invasion by targeting SIP1 in human cervical cancer cells
ConclusionOur data indicate that lowmiR-145 expression levels in conjunction with elevatedSIP1 expression levels may contribute to cervical cancer development.MiR-145-mediated regulation ofSIP1 provides a novel mechanistic basis for its tumour suppressive mode of action in human cervical cancer cells. (Source: Cellular Oncology)
Source: Cellular Oncology - December 8, 2016 Category: Cancer & Oncology Source Type: research

miR-152 down-regulation is associated with MET up-regulation in leiomyosarcoma and undifferentiated pleomorphic sarcoma
ConclusionsOur data indicate that over-expression of MET and KIT in primary STS samples and its derived cell lines is associated with miR-152 down-regulation. This shift may play a role in STS development and, thus, may be used to identify patients at risk. The effect of MET down-regulation on downstream signaling pathways, such as the PI3K/AKT pathway, may provide a basis for the future design of novel STS treatment strategies. (Source: Cellular Oncology)
Source: Cellular Oncology - November 29, 2016 Category: Cancer & Oncology Source Type: research

Collective cell migration of thyroid carcinoma cells: a beneficial ability to override unfavourable substrates
ConclusionsOur data indicate that collective migration enables tumor cells to cross otherwise unfavourable substrate areas. This capacity seems to be independent of intercellular communication via gap junctions, whereas Rac1-dependent intracellular signalling seems to be essential. (Source: Cellular Oncology)
Source: Cellular Oncology - November 8, 2016 Category: Cancer & Oncology Source Type: research

Targeting CXCR4 and FAK reverses doxorubicin resistance and suppresses invasion in non-small cell lung carcinoma
ConclusionsFrom our data we conclude that targeting of CXCR4 and FAK may overcome ABCB1 and ABCC1-dependent DOX resistance in NSCLC cells and that simultaneous treatment of these cells with DOX may potentiate the anti-invasive effects of CXCR4 and FAK inhibitors. (Source: Cellular Oncology)
Source: Cellular Oncology - November 7, 2016 Category: Cancer & Oncology Source Type: research

Erufosine increases RhoB expression in oral squamous carcinoma cells independent of its tumor suppressive mode of action - a short report
ConclusionsOur data show that erufosine can cause up-regulation of RhoB expression in OSCC cells. Combining erufosine treatment with siRNA-mediated RhoB knockdown did, however, not reveal a role of RhoB in its tumor suppressive mode of action. (Source: Cellular Oncology)
Source: Cellular Oncology - November 3, 2016 Category: Cancer & Oncology Source Type: research

Network-based expression analysis reveals key genes related to glucocorticoid resistance in infant acute lymphoblastic leukemia
AbstractPurposeDespite vast improvements that have been made in the treatment of children with acute lymphoblastic leukemia (ALL), the majority of infant ALL patients (~80  %,
Source: Cellular Oncology - October 31, 2016 Category: Cancer & Oncology Source Type: research

Inhibition of histone deacetylases sensitizes glioblastoma cells to lomustine
ConclusionFrom our data we conclude that the combined administration of TSA and CCNU eradicates GBM cells with a higher efficacy than either drug alone, thereby opening a novel avenue for the treatment of GBM. (Source: Cellular Oncology)
Source: Cellular Oncology - October 20, 2016 Category: Cancer & Oncology Source Type: research

MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report
ConclusionOur data indicate that EV miR155 may serve as an attractive new, non-invasive diagnostic biomarker in human hematologic malignancies. (Source: Cellular Oncology)
Source: Cellular Oncology - October 19, 2016 Category: Cancer & Oncology Source Type: research