Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma
ConclusionsAberrant circDHPR expression leads to uncontrolled cell proliferation, tumorigenesis, and metastasis. CircDHPR may serve as a biomarker and therapeutic target for HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 26, 2023 Category: Cancer & Oncology Source Type: research
RRM2 as a novel prognostic and therapeutic target of NF1-associated MPNST
ConclusionsRRM2 expression is significantly elevated in NF1-associated MPNST and that high RRM2 expression correlates with poorer outcomes. RRM2 acts as an integral part in the promotion of NF1-associated MPNST cell proliferation via the AKT-mTOR signaling pathway. Inhibition of RRM2 may be a promising therapeutic strategy for NF1-associated MPNST. (Source: Cellular Oncology)
Source: Cellular Oncology - April 22, 2023 Category: Cancer & Oncology Source Type: research
Dissecting the single-cell transcriptome network of macrophage and identifies a signature to predict prognosis in lung adenocarcinoma
ConclusionIn conclusion, we investigated the composition, expression differences, and phenotypic changes of macrophages from different origins in lung adenocarcinoma. In addition, we developed a prognostic prediction model based on different macrophage subtype infiltration, which can be used as a valid prognostic biomarker. New insights were provided into the role of macrophages in the prognosis and potential treatment of LUAD patients. (Source: Cellular Oncology)
Source: Cellular Oncology - April 20, 2023 Category: Cancer & Oncology Source Type: research
Targeting human mitochondrial NAD(P)+-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia
AbstractAcute myeloid leukemia (AML) is a fast-growing and highly fatal blood cancer, and recent research has shown that targeting metabolism may be a promising therapeutic approach for treating AML. One promising target is the human mitochondrial NAD(P)+-dependent malic enzyme (ME2), which is involved in the production of pyruvate and NAD(P)H and the regulation of the NAD+/NADH redox balance. Inhibition of ME2 via silencing ME2 or utilizing its allosteric inhibitor disodium embonate (Na2EA) causes a decrease in pyruvate and NADH, leading to a decrease in producing ATP via cellular respiration and oxidative phosphorylation...
Source: Cellular Oncology - April 20, 2023 Category: Cancer & Oncology Source Type: research
Comprehensive analysis of clinical prognostic features and tumor microenvironment landscape of CD11b+CD64+ patients with acute myeloid leukemia
ConclusionsThis work might be of benefit to enhanced understanding of CD11b+CD64+ in the prognosis and leukemogenesis, and yielded novel biomarkers to guide immunotherapy and targeted therapy for AML. (Source: Cellular Oncology)
Source: Cellular Oncology - April 18, 2023 Category: Cancer & Oncology Source Type: research
TBX21 attenuates colorectal cancer progression via an ARHGAP29/RSK/GSK3 β dependent manner
ConclusionsIn summary, the aforementioned findings suggest a model of TBX21 in suppressing CRC progression. This may provide a promising target for CRC therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - April 17, 2023 Category: Cancer & Oncology Source Type: research
Gallium maltolate shows synergism with cisplatin and activates nucleolar stress and ferroptosis in human breast carcinoma cells
ConclusionsThese results suggest that GaM synergizes with cisplatin via activation of nucleolar stress and ferroptosis in human breast carcinoma cells. GaM is marginally toxic to normal cells but impairs the growth of TNBC cell lines. Thus, GaM has the potential to be used as a therapeutic agent against TNBC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 17, 2023 Category: Cancer & Oncology Source Type: research
DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis
ConclusionsOur study reveals a novel mechanism by which DDX39B facilitates the malignant progression of HCC via activation of SREBP1-mediatedde novo lipogenesis, implicating DDX39B as both a potential predictor of recurrence and prognosis and a promising therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - April 13, 2023 Category: Cancer & Oncology Source Type: research
Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection
ConclusionsThe metabolic shift towards OXPHOS contributes significantly to tumor proliferation, progression, metastasis, immune escape, and poor prognosis. A thorough investigation of concrete mechanisms of OXPHOS regulation in different types of tumors and the combination usage of OXPHOS-targeted drugs with existing immunotherapies could potentially uncover new therapeutic targets for future antitumor therapies. (Source: Cellular Oncology)
Source: Cellular Oncology - April 11, 2023 Category: Cancer & Oncology Source Type: research
Exosomes: a potential diagnostic and treatment modality in the quest for counteracting cancer
ConclusionIn this review, the physiological roles played by exosomes were summarized along with their biogenesis process. Different isolation techniques of exosomes including centrifugation-based, size-based, and polymer precipitation-based techniques have also been described in detail with a special focus on cancer therapeutic applications. The review also shed light on techniques of incubation of drugs with exosomes and their characterization methods covering the most advanced techniques. Myriad applications of exosomes in cancer as diagnostic biomarkers, drug delivery carriers, and chemoresistance-related issues hav...
Source: Cellular Oncology - April 11, 2023 Category: Cancer & Oncology Source Type: research
Increased SPRY1 expression activates NF- κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis
ConclusionHigh expression of SPRY1 can function as an oncogene in PDAC by promoting cancer-associated inflammation. Targeting SPRY1 might be an important approach for designing new strategy of tumor therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - April 4, 2023 Category: Cancer & Oncology Source Type: research
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner
ConclusionsOur data indicate that sEVs secreted by GBM cells can facilitate tumour invasion by promoting invadopodia activity in recipient cells, which may be enhanced by treatment with radio-chemotherapy. The transfer of pro-invasive cargos may yield important insights into the functional capacity of sEVs in invadopodia. (Source: Cellular Oncology)
Source: Cellular Oncology - April 4, 2023 Category: Cancer & Oncology Source Type: research
The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells
ConclusionIn conclusion, the CNPY3-SLITRK4 axis contributes to liver metastasis of GC according to the TrkB-related signaling pathway. which may be a therapeutic target for the treatment of GC with liver metastasis. (Source: Cellular Oncology)
Source: Cellular Oncology - April 4, 2023 Category: Cancer & Oncology Source Type: research
The composition and roles of gastric stem cells in epithelial homeostasis, regeneration, and tumorigenesis
AbstractThe epithelial lining of the stomach undergoes rapid turnover to preserve its structural and functional integrity, a process driven by long-lived stem cells residing in the antral and corpus glands. Several subpopulations of gastric stem cells have been identified and their phenotypic and functional diversities linked to spatiotemporal specification of stem cells niches. Here, we review the biological features of gastric stem cells at various locations of the stomach under homeostatic conditions, as demonstrated by reporter mice, lineage tracing, and single cell sequencing. We also review the role of gastric stem c...
Source: Cellular Oncology - April 3, 2023 Category: Cancer & Oncology Source Type: research
Induction of promyelocytic leukemia zinc finger protein by miR-200c-3p restores sensitivity to anti-androgen therapy in androgen-refractory prostate cancer and inhibits the cancer progression via down-regulation of integrin α3β4
ConclusionThis study demonstrated that miR-200c-3p treatment of ARPC is a promising therapeutic approach to restore the sensitivity to anti-androgen therapy and inhibit tumor growth and metastasis. (Source: Cellular Oncology)
Source: Cellular Oncology - March 30, 2023 Category: Cancer & Oncology Source Type: research
