Radio-sensitization of head and neck cancer cells by a combination of poly(I:C) and cisplatin through downregulation of survivin and c-IAP2
ConclusionsOur results indicate that a combined poly(I:C) and cisplatin treatment reduces the survival and induces the radio-sensitivity of HNSCC-derived cells, thus providing a rationale for the development of novel strategies for the treatment of head and neck cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

CXCL12 expression is a bona fide predictor of recurrence in lung neuroendocrine tumours; a multicentric study with emphasis on atypical carcinoids  - a short report
ConclusionCXCL12 immunohistochemistry may serve as a potentially useful tool to better stratify LNETs, and more specifically ACs, in clinical practice. (Source: Cellular Oncology)
Source: Cellular Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Anti-tumor effect of CDK inhibitors on CDKN2A -defective squamous cell lung cancer cells
ConclusionOur data suggest a potential role of CDK inhibitors in managingCDKN2A-defective SqCLC. (Source: Cellular Oncology)
Source: Cellular Oncology - September 3, 2018 Category: Cancer & Oncology Source Type: research

Drug-induced expression of EpCAM contributes to therapy resistance in esophageal adenocarcinoma
ConclusionsFrom our data we conclude that an ACF-induced increase in EpCAM expression reflects the selection of a CSC subpopulation that underlies tumor development and drug resistance in EAC. (Source: Cellular Oncology)
Source: Cellular Oncology - August 16, 2018 Category: Cancer & Oncology Source Type: research

Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones
ConclusionsOur data indicate that the cytotoxic activity of P1 and P2 on leukemia/lymphoma cells is mediated by proteasome inhibition, leading to activation of pro-apoptotic pathways. (Source: Cellular Oncology)
Source: Cellular Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)
ConclusionsOur data indicate that metformin may play a pivotal role in modulating the anti-oxidant system, including the SOD machinery, in breast cancer-derived cells. Our observations were validated byin silico analyses, indicating a close interaction between SOD and metformin. We also found that metformin may inhibit breast cancer-derived cell proliferation through apoptosis induction via the mitochondrial pathway. Finally, we found that metformin may modulate the pro-apoptotic Bax, anti-apoptotic Bcl-2, MMP-2, MMP-9, miR-21 and miR-155 expression levels. These findings may be instrumental for the clinical management and...
Source: Cellular Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients
ConclusionsOur data suggest that lung and liver cancers require efficient single-strand break repair for their growth in order to benefit from a low aldehyde detoxification metabolism. We also propose that the ratio of XRCC1 and ALDH2 levels may serve as a useful prognostic tool in these cancer types. (Source: Cellular Oncology)
Source: Cellular Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

Correction to: β-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells
In the original version of above mentioned article an error occurred in Fig.  2. Panel g and panel h are included in the figure legend, but have not been published in the figure. (Source: Cellular Oncology)
Source: Cellular Oncology - August 7, 2018 Category: Cancer & Oncology Source Type: research

Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells
ConclusionThe antagonistic effects of Inositol-C2-PAF on cell migration and proliferation are indicative for its potential for breast cancer therapy, alone or in combination with other cytostatic drugs. (Source: Cellular Oncology)
Source: Cellular Oncology - July 25, 2018 Category: Cancer & Oncology Source Type: research

Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression
ConclusionsIn addition to controlling mitochondrial biogenesis NRF1, in conjunction with E2F4 and MYC, may play a critical role in the acquisition of human cancer characteristics. Additionally, NRF1 may orchestrate both MYC and E2F4 to regulate common target genes linked to multiple networks in the development and progression of cancer. A comprehensive understanding of this dynamic interplay will set the stage, not only for the design of novel treatment strategies, but also for the discovery of pan-cellular transcription factor regulatory strategies to predict cancer risk, therapy response and patient prognosis. (Source: Cellular Oncology)
Source: Cellular Oncology - July 25, 2018 Category: Cancer & Oncology Source Type: research

Correction to: The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications
In the title of above mentioned article the word ‘versatile’ had been replaced by ‘multifaceted’. (Source: Cellular Oncology)
Source: Cellular Oncology - July 25, 2018 Category: Cancer & Oncology Source Type: research

Mutual concessions and compromises between stromal cells and cancer cells: driving tumor development and drug resistance
ConclusionsThis review presents a holistic view on the translational potential of the interplay between stromal cells and cancer cells. This interplay is currently being employed for the development of promising preclinical and clinical biomarkers, and the design of small molecule inhibitors, antibodies and small RNAs for (combinatorial) cancer treatment options. In addition, nano-carriers, tissue scaffolds and 3-D based matrices are being developed to precisely and safely deliver these compounds. (Source: Cellular Oncology)
Source: Cellular Oncology - July 19, 2018 Category: Cancer & Oncology Source Type: research

Identification of an enhancer region within the TP63 / LEPREL1 locus containing genetic variants associated with bladder cancer risk
ConclusionsTaken together, our data show that bladder cancer risk-associated variants on chromosome 3q28 are located in an active enhancer region. Further characterization of the allele-specific activity of the identified enhancer and its target genes may lead to the identification of novel signaling pathways involved in bladder carcinogenesis. (Source: Cellular Oncology)
Source: Cellular Oncology - June 28, 2018 Category: Cancer & Oncology Source Type: research

TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms
ConclusionsFrom our data we conclude that the S100A8 and S100A9 granulocyte and plasma levels are increased in MPN patients, along with inflammation markers, depending on theirJAK2V617F mutation allele burden. We also found that S100A8/9-mediated inhibition of the proliferation-related AKT and ERK1/2 signaling pathways can be decreased byCALR mutation-dependent TLR4 blocking and increased by RAGE inhibition in MPN. (Source: Cellular Oncology)
Source: Cellular Oncology - June 26, 2018 Category: Cancer & Oncology Source Type: research

β-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells
ConclusionsFrom our data we conclude that the extent ofCTNNB1 gene promoter methylation by reactive oxygen species correlates with the migratory and invasive abilities of colon cancer cells. Our results suggest that epigenetic regulation ofCTNNB1 may serve as a novel avenue to block colon cancer cell migration and invasion. (Source: Cellular Oncology)
Source: Cellular Oncology - June 19, 2018 Category: Cancer & Oncology Source Type: research

Stromal collagen type VI associates with features of malignancy and predicts poor prognosis in salivary gland cancer
AbstractPurposeCollagen Type VI (COLVI) is an extracellular matrix protein that is upregulated in various solid tumours during tumour progression and has been shown to stimulate proliferation, suppress apoptosis and promote invasion and metastasis. It has also been described as a mediator of chemotherapy resistance and as a therapeutic target in preclinical cancer models. Here, we aimed to analyse the prognostic role of COLVI in salivary gland cancer (SGC).MethodsStromal COLVI protein expression was assessed in primary SGC specimens of 91 patients using immunohistochemistry (IHC). The IHC expression patterns obtained were ...
Source: Cellular Oncology - June 15, 2018 Category: Cancer & Oncology Source Type: research

Mesenchymal marker and LGR5 expression levels in circulating tumor cells correlate with colorectal cancer prognosis
AbstractPurposeThe presence of circulating tumor cells (CTCs) has been found to correlate with colorectal cancer (CRC) prognosis, whereas epithelial-mesenchymal transition (EMT) in CTCs has been found to be associated with CRC metastasis. LGR5 is a known target of Wnt signaling and plays an important role in CRC development. The aim of this study was to assess the clinical relevance of EMT and LGR5 expression in CTCs from CRC patients.MethodsSixty-six CRC patients were included in this study. The detection and expression of EMT phenotypes in CTCs from these patients were assessed using CanPatrol ™ CTC enrichment and ...
Source: Cellular Oncology - June 14, 2018 Category: Cancer & Oncology Source Type: research

Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation
ConclusionsOur data reveal a dual mode of action of STF-31, serving either as a NAMPT or as a GLUT inhibitor, whereby the latter seems to be apparent only at higher STF-31 concentrations. The molecular basis of such a dual function and its appearance in compounds previously designated as NAMPT-specific inhibitors requires further investigation. (Source: Cellular Oncology)
Source: Cellular Oncology - June 11, 2018 Category: Cancer & Oncology Source Type: research

AAA+ ATPases Reptin and Pontin as potential diagnostic and prognostic biomarkers in salivary gland cancer - a short report
ConclusionsOur results suggest a role of Reptin and Pontin in SGC tumor progression and/or  patient survival. Therefore, SGC patients exhibiting a high Reptin expression may benefit from more aggressive therapeutic regimens. Future studies should clarify whether such patients may be considered for more radical surgery, extended adjuvant therapy and/or targeted therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - June 5, 2018 Category: Cancer & Oncology Source Type: research

Patched-2 functions to limit Patched-1 deficient skin cancer growth
ConclusionsWe conclude that like Ptch1, Ptch2 exerts a tumor-suppressive function in BCC cells, and that after targeting of both paralogs, ligand-independent activation of the Hh pathway contributes to tumor growth. (Source: Cellular Oncology)
Source: Cellular Oncology - June 4, 2018 Category: Cancer & Oncology Source Type: research

Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells
ConclusionsFrom our data we conclude that the exosomal proteins identified may be considered as potential non-invasive biomarkers for chemo-resistance and partial EMT in HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research

Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target
ConclusionsThe central role of PKM2 in directing the flow of carbon between catabolic (ATP-producing) and anabolic processes provides unique opportunities for extending the therapeutic window of currently available and/or novel anti-neoplastic agents. (Source: Cellular Oncology)
Source: Cellular Oncology - May 24, 2018 Category: Cancer & Oncology Source Type: research

Potential of the dual mTOR kinase inhibitor AZD2014 to overcome paclitaxel resistance in anaplastic thyroid carcinoma
ConclusionsOur data support results from recent phase I clinical trials using combinations of AZD2014 and PTX for the treatment of solid tumors. Such combinations may also be employed for the design of novel targeted ATC treatment strategies. (Source: Cellular Oncology)
Source: Cellular Oncology - May 22, 2018 Category: Cancer & Oncology Source Type: research

Identification of subsets of actionable genetic alterations in KRAS-mutant lung cancers using association rule mining
ConclusionsI identified several genes that are co-mutated in primary KRAS-mutant lung cancer samples. I also identified subpopulations of KRAS-mutant lung cancers based on sets of genes that were co-mutated. Pre-clinical models that capture these subsets of KRAS-mutant tumors may enhance our understanding of lung cancer development and, in addition, facilitate the design of personalized treatment strategies for lung cancer patients carrying KRAS mutations. (Source: Cellular Oncology)
Source: Cellular Oncology - April 20, 2018 Category: Cancer & Oncology Source Type: research

The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications
ConclusionsThis review highlights the important role of exosomes in cancer progression and its implications for (non-invasive) diagnostics and the development of novel therapeutic strategies, as well as its current and future applications in clinical trials. (Source: Cellular Oncology)
Source: Cellular Oncology - April 17, 2018 Category: Cancer & Oncology Source Type: research

Genetics of personalized medicine: cancer and rare diseases
AbstractThe 21st annual meeting of the Portuguese Society of Human Genetics (SPGH), organized by Lu ísa Romão, Ana Sousa and Rosário Pinto Leite, was held in Caparica, Portugal, from the 16th to the 18th of November 2017. Having entered an era in which personalized medicine is emerging as a paradigm for disease diagnosis, treatment and prevention, the program of this meeting intended to include lectures by leading national and international scientists presenting exceptional findings on the genetics of personalized medicine. Various topics were discussed, including cancer genetics, transcriptome dynamic...
Source: Cellular Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis
ConclusionsDetailed understanding of the mechanisms underlying BCLM will shed a new light on the identification of novel molecular targets to impede daunting pulmonary metastases in patients with breast cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - March 22, 2018 Category: Cancer & Oncology Source Type: research

Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors
ConclusionsOur observation that ZEB2 negatively regulates a GalNAc-transferase (GALNT3) that is involved in O-glycosylation adds another layer of complexity to the role of ZEB2 in cancer progression and metastasis. Proteins glycosylated by GALNT3 may be exploited as novel diagnostics and/or therapeutic targets. (Source: Cellular Oncology)
Source: Cellular Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis
ConclusionsOur data indicate that tumor-derived CAFs can induce up-regulation of genes involved in breast cancer progression. Our data additionally indicate that CAFs, especially those derived from MMP11+ MIC tumors, can promote breast cancer cell invasion and angiogenesis. (Source: Cellular Oncology)
Source: Cellular Oncology - March 1, 2018 Category: Cancer & Oncology Source Type: research

Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner
ConclusionsFrom our results we conclude that DENSpm-induced apoptotic cell death is increased when autophagy is inhibited by 3-MA or Beclin-1 siRNA through PA depletion and PA catabolic activation in colon cancer cells, regardless p53 mutation status. (Source: Cellular Oncology)
Source: Cellular Oncology - February 28, 2018 Category: Cancer & Oncology Source Type: research

A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells
ConclusionsFrom our data we conclude that the mechanisms underlying hypoxia-induced CD133-mediated cisplatin resistance may be instrumental for the design of new GBM treatment strategies. (Source: Cellular Oncology)
Source: Cellular Oncology - February 28, 2018 Category: Cancer & Oncology Source Type: research

Diagnostic and prognostic relevance of salivary microRNA-21, -125a, -31 and -200a levels in patients with oral lichen planus - a short report
AbstractBackgroundOral lichen planus (OLP), a relatively common chronic inflammatory disease of the oral mucosa, is considered to be a premalignant disorder of the oral cavity. Previously, several biomarkers have been tested for their diagnostic potential. Here, we aimed to investigate the diagnostic potential of four miRNAs, miR-21, -125a, -31 and -200a, known to be involved in oral squamous cell carcinoma (OSCC) development, in the saliva of OLP patients as also their putative relation to OSCC development in these patients.Materials and methodsSaliva samples from 30 patients with OLP were collected, 15 of whom were diagn...
Source: Cellular Oncology - February 26, 2018 Category: Cancer & Oncology Source Type: research

Expression and function of immune ligand-receptor pairs in NK cells and cancer stem cells: therapeutic implications
AbstractBackgroundThe interplay between the immune system and cancer cells has come to the forefront of cancer therapeutics, with novel immune blockade inhibitors being approved for the treatment of an increasing list of cancers. However, the majority of cancer patients still display or develop resistance to these promising drugs. It is possible that cancer stem cells (CSCs) are contributing to this therapeutic resistance. Although CSCs usually represent a small percentage of the total number of cancer cells, they are endowed with the ability of self-renewal and to produce differentiated progeny. Additionally, they have sh...
Source: Cellular Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research

Strong enhancement by IGF1-R antagonists of hepatocellular carcinoma cell migration inhibition by Sorafenib and/or vitamin K1
ConclusionsOur results indicate that modulation of the efficacy of Sorafenib through combinations with VK1 and/or IGF1-R antagonists results in synergistic inhibition of HCC cell migration. (Source: Cellular Oncology)
Source: Cellular Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research

p53 expression and subcellular survivin localization improve the diagnosis and prognosis of patients with diffuse astrocytic tumors
ConclusionsOur data suggest that subcellular survivin localization and p53 expression may be employed as valuable tools to improve the accuracy of the histological sub-classification of diffuse astrocytic tumors. Patients whose tumors overexpress these proteins may benefit from radiotherapy, irrespective age and/or histological classification. (Source: Cellular Oncology)
Source: Cellular Oncology - January 26, 2018 Category: Cancer & Oncology Source Type: research

Concomitant high expression of ER α36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior
AbstractPurposePapillary thyroid cancer (PTC) is more common in women than in men. It has been suggested that estrogen may be involved in its development, as has previously been shown for breast, endometrial and ovarian cancer. The purpose of this study was to assess correlations between the expression of the estrogen receptor alpha36 (ER α36) and the glucose regulated proteins GRP78 and GRP94 (chaperones involved in glycoprotein folding) and various PTC clinicopathological features, as well as to evaluate the potential usefulness of these three potential oncogenic proteins in the prediction of aggressive PTC behavio...
Source: Cellular Oncology - January 24, 2018 Category: Cancer & Oncology Source Type: research

Fibroblast growth factor receptor 1 and 3 expression is associated with regulatory PI3K/AKT kinase activity, as well as invasion and prognosis, in human laryngeal cancer
AbstractPurposeAberrant fibroblast growth factor receptor (FGFR) expression is thought to contribute to the development of many types of cancer. As yet, however, their impact on the course and prognosis of head and neck cancer remains to be determined. Here, we aimed to investigate the effects of expression of the FGFR family members FGFR1 and FGFR3, as well as their downstream PI3K/AKT signal-regulated kinases, on the aggressiveness and prognosis of laryngeal cancer.MethodsIn total 137 surgically removed squamous cell laryngeal cancer (SCLC) and 100 matched non-cancerous laryngeal mucosa (NCLM) samples were assessed for m...
Source: Cellular Oncology - January 3, 2018 Category: Cancer & Oncology Source Type: research

Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells
ConclusionsFrom our data we conclude that combinations of panobinostat and the topoisomerase inhibitors topotecan or etoposide provoke strong cell death responses in cervical cancer-derived cells via induction of the intrinsic apoptotic pathway. Since this drug combination may potentially be effective in the treatment of cervical cancer, further preclinical investigations are warranted. (Source: Cellular Oncology)
Source: Cellular Oncology - December 19, 2017 Category: Cancer & Oncology Source Type: research

Role of β-catenin in cisplatin resistance, relapse and prognosis of head and neck squamous cell carcinoma
ConclusionFrom our results we conclude that β-catenin may contribute to HNSCC therapy resistance and disease relapse. As such, β-catenin may be explored as a therapeutic target along with conventional therapeutics. (Source: Cellular Oncology)
Source: Cellular Oncology - December 14, 2017 Category: Cancer & Oncology Source Type: research

A2B adenosine receptor agonist induces cell cycle arrest and apoptosis in breast cancer stem cells via ERK1/2 phosphorylation
ConclusionsFrom our results we conclude that A2BAR induces breast CSC cell cycle arrest and apoptosis through downregulation of the ERK1/2 cascade. As such, A2BAR may be considered as a novel target for the treatment of breast cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - December 7, 2017 Category: Cancer & Oncology Source Type: research

Establishing cut-off points with clinical relevance for bcl-2, cyclin D1, p16, p21, p27, p53, Sox11 and WT1 expression in glioblastoma - a short report
AbstractPurposeGlioblastoma (GBM) ranks among the most challenging cancers to treat and there is an urgent need for clinically relevant prognostic and diagnostic biomarkers. Here, we set out to investigate the expression of eight proteins (bcl-2, cyclin D1, p16, p21, p27, p53, Sox11 and WT1) in GBM with the specific aim to establish immunohistochemistry cut-off points with clinical relevance.MethodsImmunohistochemistry (IHC) was used to examine protein expression in 55 surgical GBM specimens using H-scores, and IHC cut-off points were established using the Cutoff Finder web platform. Protein co-expression and its correlati...
Source: Cellular Oncology - December 7, 2017 Category: Cancer & Oncology Source Type: research

Role of Glypican-3 in the growth, migration and invasion of primary hepatocytes isolated from patients with hepatocellular carcinoma
ConclusionOur data reveal new aspects of the role of GPC3 in early hepatocyte transformation. In addition we conclude that GPC3 may serve as a new HCC immune-therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - December 4, 2017 Category: Cancer & Oncology Source Type: research

Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells
ConclusionsBased on our results we conclude that AREG is involved in regulating the proliferation and migration of erbB2/HER2-positive breast cancer cells. (Source: Cellular Oncology)
Source: Cellular Oncology - November 27, 2017 Category: Cancer & Oncology Source Type: research

LOX-1 is a poor prognostic indicator and induces epithelial-mesenchymal transition and metastasis in pancreatic cancer patients
ConclusionsFrom our data we conclude that a high LOX-1 expression in PC tissues is indicative for the occurrence of lymph node metastases, high TNM stages and a poor prognosis. LOX-1 may serve as an independent prognostic biomarker. Our in vitro assays additionally revealed that LOX-1 may enhance the migration and invasion of PC cells through EMT. LOX-1 may also serve as a novel therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - November 22, 2017 Category: Cancer & Oncology Source Type: research

Glycogen synthase kinase-3 β mediated regulation of matrix metalloproteinase-9 and its involvement in oral squamous cell carcinoma progression and invasion
ConclusionsCollectively, our results show that MMP-9 overexpression and activation are important events occurring during OSCC progression/invasion and that this overexpression/activation is regulated by c-Myc, active MMP-2 and inactive GSK3 β mediated pathways. (Source: Cellular Oncology)
Source: Cellular Oncology - November 13, 2017 Category: Cancer & Oncology Source Type: research

Diterpenoid natural compound C4 (Crassin) exerts cytostatic effects on triple-negative breast cancer cells via a pathway involving reactive oxygen species
ConclusionsFrom ourin vitro data we conclude that C4 exerts cytostatic effects on triple-negative breast cancer cells via a pathway involving reactive oxygen species. Its potential value in combination with cytotoxic therapies merits deeper investigation in pre-clinical models. (Source: Cellular Oncology)
Source: Cellular Oncology - November 13, 2017 Category: Cancer & Oncology Source Type: research

A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report
ConclusionsFrom our data we conclude that AP-1060 may serve as a first publicly available preclinical model for EN. In addition, we conclude that these EN-positive cells are sensitive to the NTRK inhibitor AZ-23 and that this inhibitor may potentiate the therapeutic efficacy of ATO. Our data also highlight a novel AML EN target,MALAT1, which was so far only conspicuous in solid tumors. (Source: Cellular Oncology)
Source: Cellular Oncology - November 8, 2017 Category: Cancer & Oncology Source Type: research

Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma
AbstractPurposeExosomal miRNAs that play an important role in cell-cell communication have attracted major attention as potential diagnostic and prognostic biomarkers for various cancers. The aim of this study was to determine the diagnostic/prognostic significance of serum exosomal miR-301a in glioma patients.MethodsQuantitative real-time PCR was used to determine the serum exosomal expression levels of miR-301a. Kaplan-Meier survival analyses, Cox regression analyses and ROC working curve analyses were applied to assess the diagnostic and prognostic values of miR-301a in glioma patients. Also, several in vitro assays wer...
Source: Cellular Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Metabolic iodine and tumours
ConclusionConclusion drawn is that a tumour control method derives from the relationship studied. (Source: Cellular Oncology)
Source: Cellular Oncology - October 16, 2017 Category: Cancer & Oncology Source Type: research

Memory CD4 + T cell subsets in tumor draining lymph nodes of breast cancer patients: A focus on T stem cell memory cells
ConclusionOur data suggest that following long-term exposure to putative tumor antigens, TSCM cells proliferate to generate a pool of committed memory and effector T cells. As the tumor progresses, the immunosuppressive milieu induced by tumor cells may slow down the differentiation of CD45ROLow TCM cells to more functional sub-populations. (Source: Cellular Oncology)
Source: Cellular Oncology - October 9, 2017 Category: Cancer & Oncology Source Type: research