Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer

ConclusionNon-canonical Hh signaling pathway, involving cooperation between Hh ligands and their receptor Ptch1, facilitates the degradation of EGFR and attenuates its activity in NSCLC. These findings provide novel insights into the regulation of EGFR protein stability and activity, offer new diagnostic indicators for molecular typing of NSCLC and identify potential targets for targeted therapy of this challenging disease.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research