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Nutrition: Sodium

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Assessing fresh water acute toxicity with Surface-Enhanced Raman Scattering (SERS)
This study provides a promising SERS method for assessing acute toxicity in water bodies with high sensitivity and short detection time.PMID:37690416 | DOI:10.1016/j.talanta.2023.125163
Source: Talanta - September 10, 2023 Category: Chemistry Authors: Weixing Gao Wanli Fan Dongmei Wang Ji Sun Yong Li Changyu Tang Meikun Fan Source Type: research

Fabrication and characterization of manganese dioxide (MnO < sub > 2 < /sub > ) nanoparticles and its degradation potential of benzene and pyrene
In this study, MnO2 nanoparticles were synthesized chemically using sodium thiosulphate as reducing agent. MnO2 nanoparticles were characterized using UV-visible adsorption spectroscopy and Fourier Transform Infrared Spectroscopy (FTIR). A X-Ray Diffraction Spectrophotometer (XRD), a Scanning Electron Microscopy - Energy Dispersive X-Ray Analyzer (SEM-EDAX), and Dynamic Light Scattering (DLS) were used to identify the crystalline nature and particle size of the fabricated MnO2 nanoparticles. Batch adsorption studies were conducted to identify the optimal conditions for better benzene and pyrene adsorption from aqueous solu...
Source: Chemosphere - September 10, 2023 Category: Chemistry Authors: Kathirvel Brindhadevi Seerangaraj Vasantharaj Quynh Hoang Le Sandhanasamy Devanesan Karim Farhat Xinghui Liu Source Type: research

High calcium concentrations reduce cellular excitability of mouse MNTB neurons
Brain Res. 2023 Sep 7:148568. doi: 10.1016/j.brainres.2023.148568. Online ahead of print.ABSTRACTCalcium, a universal intracellular signaling molecule, plays essential roles in neural functions. Historically, in most in vitro brain slice electrophysiology studies, the extracellular calcium concentration ([Ca2+]e) in artificial cerebrospinal fluid is of a wide range and typically higher than the physiological value. At high [Ca2+]e, synaptic transmission is generally enhanced. However, the effects and the underlying mechanisms of calcium on intrinsic neuronal properties are diverse. Using whole-cell patch clamp in acute bra...
Source: Brain Research - September 9, 2023 Category: Neurology Authors: Huimei Wang Yong Lu Source Type: research

Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus
This study serves as an example of the identification of new peptide toxins from historical DNA and provides new insights into structure-activity relationships of µ-conotoxins with activity at hNaV1.3 and hNaV1.7.PMID:37689602 | PMC:PMC10492761 | DOI:10.1007/s00018-023-04935-0
Source: Cellular and Molecular Life Sciences : CMLS - September 9, 2023 Category: Cytology Authors: Kirsten L McMahon Henrik O'Brien Christina I Schroeder Jennifer R Deuis Dhananjeyan Venkatachalam Di Huang Brad R Green Pradip K Bandyopadhyay Qing Li Mark Yandell Helena Safavi-Hemami Baldomero M Olivera Irina Vetter Samuel D Robinson Source Type: research

Exploring the impact of sodium salts on the hydrotropic solubilization
Phys. Chem. Chem. Phys., 2023, Accepted Manuscript DOI: 10.1039/D3CP02034G, PaperJordana Benfica, Afonso Cerqueira Martins, German Perez-Sanchez, Nicolas Schaeffer, Joao A. P. Coutinho Some ionic liquids (IL) were shown to display a strong ability to enhance the solubility of phenolic compounds through hydrotropy. However, evidence shows that salt ions in hydrotropic aqueous solutions... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - September 8, 2023 Category: Chemistry Authors: Jordana Benfica Source Type: research

SBP1 promotes tumorigenesis of thyroid cancer through TXN/NIS pathway
CONCLUSION: SBP1 promoted tumorigenesis and dedifferentiation of thyroid cancer through positively regulating TXN.PMID:37684566 | DOI:10.1186/s10020-023-00700-y
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Jiancang Ma Xin Huang Jinkai Xu Zongyu Li Jingyue Lai Yawei Shen Jun Zhao Xuejun Sun Lieting Ma Source Type: research

A base-mediated synthesis of < em > N < /em > -hydroxy- and < em > N < /em > -alkoxyindoles from 2-nitrostyrenes
Tetrahedron. 2023 Sep 7;144:133578. doi: 10.1016/j.tet.2023.133578. Epub 2023 Aug 6.ABSTRACTSequential treatment of alkyl 2-(2-nitroaryl)-2-butenoates with potassium tert-butoxide and an electrophile, such as methyl iodide, benzyl bromide and allyl bromide, afforded N-alkoxyindoles. In related reactions, using sodium tert-pentoxide as the base with or without in situ addition of an electrophile afforded N-alkoxy- and N-hydroxyindoles, respectively. Electrophiles such as dimethylsulfate, p-tosyl chloride, and acetic anhydride afforded moderate yields of the respective N-methoxy-, N-tosyloxy, and N-acetoxyindoles, while meth...
Source: Tetrahedron - September 8, 2023 Category: Chemistry Authors: Blaine T McClay Katharine E Lambson Serge R Banini Tural N Akhmedov Bj örn C G Söderberg Source Type: research

Potential protective effects of the water-soluble Chinese propolis on experimental ulcerative colitis
CONCLUSION: WSP downregulates OS by enhancing the function of endogenous antioxidant enzymes like SOD and GSH-Px, that inhibit neutrophil activity, as well as diminish pro-inflammatory cytokines like TNF-ɑ, IL-6, and IL-9, along with mechanisms that attenuate intestinal inflammation in UC rat model.PMID:37679980 | PMC:PMC10465833 | DOI:10.19852/j.cnki.jtcm.20230727.002
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Zhou Hua L I Hui Wang Haihua Source Type: research

Extraction, characterization and controlled release application of pectin-like/chitosan hydrogels system loaded Ciprofloxacin
CONCLUSION: The novel pectin-chitosan hydrogels hold the potential to enhance the quality of life for numerous patients by minimizing the need for frequent intake of chronic medications.PMID:37680160 | DOI:10.2174/1567201821666230901153513
Source: Current Drug Delivery - September 8, 2023 Category: Drugs & Pharmacology Authors: Amer Rashid Hameed Zeineb Mzoughi Mariem Itaimi Dammak Fawzi Habeeb Jabrail Didier Le Cerf Hatem Majdoub Source Type: research

Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction
CONCLUSIONS: Cardiac conduction does not correlate with extracellular resistance but is biphasically related to perinexal separation, providing evidence that the relationship between CV and extracellular volume is determined by ephaptic mechanisms under conditions of normal gap junctional coupling.PMID:37681314 | DOI:10.1161/CIRCRESAHA.123.322567
Source: Circulation Research - September 8, 2023 Category: Cardiology Authors: William P Adams Tristan B Raisch Yajun Zhao Rafael Davalos Sarah Barrett D Ryan King Chandra B Bain Katrina Colucci-Chang Grace A Blair Alexandra Hanlon Alicia Lozano Rengasayee Veeraraghavan Xiaoping Wan Isabelle Deschene James W Smyth Gregory S Hoeker R Source Type: research

Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
CONCLUSION: Our data suggest a novel electrolyte-based mechanism of immunosuppression in malignant ascites of patients with peritoneal carcinomatosis. We show for the first time that the immunosuppression of NK cytotoxicity in coculture assays is correlated to patient poor survival. Therapeutic application of sodium channel inhibitors may provide new means for restoring immune cell activity in ascites or similar electrolyte imbalanced environments.PMID:37684704 | DOI:10.1186/s13046-023-02798-8
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Antonio Hrvat Mathias Schmidt Bernd Wagner Denise Zwanziger Rainer Kimmig Lothar Volbracht Sven Brandau Nina Mallmann-Gottschalk Source Type: research

Combined Effects of Fluoride and Dietary Seleno-L-Methionine at Environmentally Relevant Concentrations on Female Zebrafish (Danio rerio) Liver: Histopathological Damages, Oxidative Stress and Inflammation
In this study, female zebrafish (Danio rerio) were exposed to fluoride (80 mg/L sodium fluoride) and/or dietary selenomethionine (Se-Met) for 30, 60 and 90 days, the effects on the liver of zebrafish were investigated. The results indicated that an increase in fluoride burden, inhibited growth and impaired liver morphology were recorded after fluoride exposure. Furthermore, fluoride alone caused oxidative stress and inflammation in the liver, as reflected by the increase in ROS and MDA contents, the reduction of anti-oxidative enzymes, the altered immune related enzymes (ACP, AKP, LZM and MPO) and the expression of IL-6, I...
Source: Biological Trace Element Research - September 8, 2023 Category: Biology Authors: Xiulin Zhang Jinling Cao Jianjie Chen Guodong Wang Lijuan Li Xiaobing Wei Runxiao Zhang Source Type: research

Alterations of Bax/Bcl-2 ratio contribute to NaAsO < sub > 2 < /sub > induced thyrotoxicity in human thyroid follicular epithelial cells and SD rats
Ecotoxicol Environ Saf. 2023 Sep 6;264:115449. doi: 10.1016/j.ecoenv.2023.115449. Online ahead of print.ABSTRACTThe environmental toxicant arsenic causes various human diseases and threatens millions of people worldwide. Recently, a limited number of studies have revealed that exposure to arsenic is associated with thyroid dysfunction, indicating its toxicological impact on the thyroid gland, however, its precise forms of damage and underlying mechanisms remain largely unknown. Here, we sought to observe the thyrotoxicity of sodium arsenite (NaAsO2) on human thyroid follicular epithelial cells (Nthy-ori 3-1) and SD rats, a...
Source: Ecotoxicology and Environmental Safety - September 8, 2023 Category: Environmental Health Authors: Lili Fan Zhiqin He Lei Wang Huijie Gaoyang Dapeng Wang Peng Luo Source Type: research