Natural Product-Inspired Molecules for Covalent Inhibition of SHP2 Tyrosine Phosphatase
Tetrahedron. 2024 Apr 28;156:133918. doi: 10.1016/j.tet.2024.133918. Epub 2024 Mar 2.ABSTRACTNatural products have been playing indispensable roles in the development of lifesaving drug molecules. They are also valuable sources for covalent protein modifiers. However, they often are scarce in nature and have complex chemical structures, which are limiting their further biomedical development. Thus, natural product-inspired small molecules which still contain the essence of the parent natural products but are readily available and amenable for structural modification, are important and desirable in searching for lead compou...
Source: Tetrahedron - April 15, 2024 Category: Chemistry Authors: Weida Liang Aaron D Krabill Katelyn S Gallagher Christine Muli Zihan Qu Darci Trader Zhong-Yin Zhang Mingji Dai Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
Photocatalytic conversion of aryl diazonium salts to sulfonyl fluorides
We present the optimization of this mild method for the synthesis of sulfonyl fluorides, the scope of the transformation with a series of functionalized diazonium salts, and we discuss photophysical measurements that provide detailed information about the mechanism of the photochemical process.PMID:38404686 | PMC:PMC10887421 | DOI:10.1016/j.tet.2023.133364 (Source: Tetrahedron)
Source: Tetrahedron - February 26, 2024 Category: Chemistry Authors: Cooper A Vincent Alexia Ripak Ludovic Troian-Gautier Uttam K Tambar Source Type: research
