A new agent for contrast-enhanced intravascular ultrasound imaging in vitro: polybutylcyanoacrylate nanoparticles with drug-carrying capacity
This study prepared and evaluated polymeric polybutylcyanoacrylate (PBCA) nanoparticles (NPs) that can be used as a new agent for contrast-enhanced intravascular ultrasound (IVUS) imaging with drug delivery capacity. The nanoformulation was successfully developed using suspension polymerisation and characterised in terms of size, size distribution, zeta potential, morphology, stability, toxicity effects, imaging effects and drug release study. The results showed that the nanoparticles were round and hollow, with a particle diameter of 215.8 ± 25.3 nm and a zeta potential of -22.2 ± 4.1 mV. In vitro experiments, the nanop...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 22, 2024 Category: Biotechnology Authors: Congying Wang Haodong Jiang Jia Zhu Yunpeng Jin Source Type: research

Exploring fibroblast interactions on nanocrystalline surfaces in physiological environments through a phenomenological lens
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):229-237. doi: 10.1080/21691401.2024.2338127. Epub 2024 Apr 8.ABSTRACTThe cytological behaviour and functional dynamics (adhesion, spreading, synthesis of proteins) of fibroblasts when interacting with biomedical surfaces are intricately influenced by the inherent nature of surface (nanocrystalline or microcrystalline), where the nanocrystalline (NC) surface is preferred in relation to the microcrystalline (MC) surface. This preference is a direct consequence of the distinct differences in physical and chemical characteristics between NC and MC surfaces, which include crystal b...
Source: Artificial Cells, Nanomedicine and Biotechnology - April 9, 2024 Category: Biotechnology Authors: R D K Misra Aladin M Boriek Source Type: research

Assessment of progression of pulmonary fibrosis based on metabonomics and analysis of intestinal microbiota
Artif Cells Nanomed Biotechnol. 2024 Dec;52(1):201-217. doi: 10.1080/21691401.2024.2326616. Epub 2024 Mar 15.ABSTRACTThe main purpose of this study was to explore the changes of biomarkers in different developmental stages of bleomycin-induced pulmonary fibrosis (PF) in rats via comprehensive pathophysiology, UPLC-QTOF/MS metabonomic technology, and 16S rRNA gene sequencing of intestinal microbiota. The rats were randomly divided into normal control and 1-, 2- and 4-week model group. The rat model of PF was established by one-time intratracheal instillation of bleomycin. The levels of inflammatory and fibrosis-related fact...
Source: Artificial Cells, Nanomedicine and Biotechnology - March 15, 2024 Category: Biotechnology Authors: Jia-Qi Liu Hong-Bing Zhou Wan-Fu Bai Jia Wang Qian Li Li-Ya Fan Hong Chang Song-Li Shi Source Type: research