Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Better Understanding the Outcome of Destroying and Rebuilding the Immune System
The use of chemotherapy to destroy as much of the peripheral immune system as possible, followed by some form of stem cell transplant to rebuild it, has been used for some years as a way to treat multiple sclerosis. In this autoimmune condition, the problem resides in the immune memory, and getting rid of that memory is the solution. The only approach currently demonstrated to work is this somewhat drastic treatment, and the balance of risk and cost means that it is only used for severe diseases such as multiple sclerosis. But in principle, clearance and restoration of the immune system could solve a great many of the issu...
Source: Fight Aging! - November 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why adopt a lifestyle pyramid for rheumatoid arthritis?
Rheumatoid arthritis is a common autoimmune disease affecting approximately 1.5 million people only in the United States. The most common symptoms that will bring patients to the doctor are: pain swelling and stiffness in multiple joints. most of the time, in a bilateral and symmetric pattern Unfortunately, rheumatoid arthritis is not only a disease of
Read more…
Why adopt a lifestyle pyramid for rheumatoid arthritis? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 2, 2022 Category: General Medicine Authors: Diana M. Girnita, MD, PhD Tags: Conditions Rheumatology Source Type: blogs
I am stupid
Conclusion: Isaac Asimov is stupid(Sorry, no post yesterday because I was doing some heavy cerebral processing.)He ' d have been the first to admit it. All of us are susceptible to cognitive errors and biases. I ' d like to think that Asimov was less susceptible than most, but he must have had his own foibles. It ' s a constant struggle to be mindful and think straight. For my own part, I once had a romanticized view of the Chinese revolution, I was an anthropogenic climate change skeptic, and I entertained the likelihood that medical intervention, on balance, did more harm than good. (Viz Illich, Medical Nemesis.)&nb...
Source: Stayin' Alive - October 28, 2022 Category: American Health Source Type: blogs
Does Surviving The Plague Mean You Will Eventually Contract An Autoimmune Disease?
BY MIKE MAGEE
This Fall, I am teaching a 4-week course on “How Epidemics Have Shaped Our World” at the President’s College at the University of Hartford. It is, of course a timely topic, but also personally unnerving as we complete a third year under the shadow of Covid-19.
Where does one begin on a topic such as this? Yale historian, Frank M. Snowden, in his book “Epidemics and Society: From the Black Death to the Present”, made his intentions obvious. He would begin with the plaque. Why? His answer, “The word ‘plague’ will always be synonymous with ‘terror’”, and especially references:
...
Source: The Health Care Blog - October 26, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Autoimmune. Disease Mike Magee Plague Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Stress Provokes Inflammation via Fragments of Mitochondrial DNA
A large body of evidence links mitochondrial dysfunction with chronic inflammation. These are both features of aging, but it appears that dysfunctional, stressed mitochondria are a meaningful cause of inflammatory signaling. Mitochondria can generate molecular fragments, such as pieces of mitochondrial DNA, that are recognized as potentially threatening by the innate immune system. These damage-associated molecular patterns are present in much greater amounts in old tissues, and the immune system reacts to them to produce lasting, unresolved inflammation, harmful to tissue function rather than protective.
In today's...
Source: Fight Aging! - October 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Why do Some People Develop Long COVID?
by Gertrud U. Rey Long COVID is a chronic manifestation of SARS-CoV-2 infection, and it is most commonly characterized by lingering fatigue, brain fog, memory impairment, and confusion. Although it is unclear how the viral infection leads to long COVID, experts speculate that one or more of the following factors may contribute: an inability to […] (Source: virology blog)
Source: virology blog - October 6, 2022 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey Akiko Iwasaki autoimmune disease autoimmunity biomarker chronic fatigue syndrome cortisol COVD-19 cytotoxic T cells diagnostic test EBV Epstein-Barr virus exhausted T cells inflammation latent Lon Source Type: blogs
Alzheimer's Disease as Innate Autoimmunity
The failure of amyloid-β clearance via immunotherapy to produce benefits in Alzheimer's disease patients has spurred a great deal of theorizing, attempts to find a new way forward. Most researchers, from a survey of the field, continue to believe that amyloid-β aggregation is an important contributing factor in at least the early development of Alzheimer's. However, an increasing emphasis on immune dysfunction and chronic inflammation is creeping into modified versions of the amyloid cascade hypothesis, alongside different interpretations of the role of amyloid-β in this process, based on its participation in the innate...
Source: Fight Aging! - October 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Targeting the Gut Microbiome to Treat Aging
The distribution of microbial populations making up the gut microbiome changes with age in ways that are harmful to health, causing a reduction in production of beneficial metabolites and an increase in chronic inflammation. Animal studies make it clear that some approaches to restoring a more youthful gut microbiome, such as fecal microbiota transplantation from young donors, can produce a sustained rejuvenation of the gut microbiome and consequent improvement in later life health. Given the comparatively simplicity of this approach, and that the state of the gut microbiome can accurately measured via low-cost assays, thi...
Source: Fight Aging! - October 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Focus on the rheumatoid arthritis patient, not on their disease
Medical school, residency, and fellowship taught me pathophysiology, diagnosis, and the most advanced treatments for autoimmune diseases like rheumatoid arthritis. As an attending physician, seeing my own patients, I noticed that targeted therapy is not able to control the disease in all patients with rheumatoid arthritis. The results varied. I could not stop asking myself,
Read more…
Focus on the rheumatoid arthritis patient, not on their disease originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 16, 2022 Category: General Medicine Authors: Diana M. Girnita, MD, PhD Tags: Conditions Rheumatology Source Type: blogs
Fight Aging! Newsletter, September 12th 2022
Discussion of Present Drug Development to Target Senescent Cells
Targeting Senescent Cells to Better Address Cancer and Consequences of Cancer Therapy
Calorie Restriction Suppresses Generation of Immune Cells via Changes to the Gut Microbiome
Arguing for an Expansion of the Hallmarks of Aging
https://www.fightaging.org/archives/2022/09/arguing-for-an-expansion-of-the-hallmarks-of-aging/
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. Thi...
Source: Fight Aging! - September 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, September 5th 2022
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Data on Plasma Dilution in Humans
Diluting blood plasma in old individuals reduces circulating levels of harmful signals, such as pro-inflammatory proteins and debris, for long enough to allow improvement in tissue function. Significant dilution requires the introduction of new albumin, and there is presently some question over how much of the benefits result from the dilution of circulating factors versus delivery of albumin which is typically sourced from blood donations from (on average) younger individuals, and is thus less damaged. Researchers here report on the effects of repeated plasma dilution treatments in three human patients, showing an improve...
Source: Fight Aging! - September 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
