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Nutrition: Antidoxidants
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Diverse pharmacological potential of pyridazine analogs against various diseases
Med Chem. 2023 Sep 13. doi: 10.2174/1573406419666230913102835. Online ahead of print.ABSTRACTPyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyrida...
Source: Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mohammad Asif Mazen M Almehmadi Ahad Amer Alsaiari Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Molecular Biology Reports - September 15, 2023 Category: Molecular Biology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
Storage stability of chocolate can be enhanced using locust protein-based film incorporated with E. purpurea flower extract-based nanoparticles
Ultrason Sonochem. 2023 Sep 7;100:106594. doi: 10.1016/j.ultsonch.2023.106594. Online ahead of print.ABSTRACTThe study aimed to develop a locust protein (Loct-Prot)-based film to enhance the lipid oxidative and storage stability of chocolate. The E. purpurea flower extract based-nanoparticles (EFNPs) were developed using ultrasonication (500 W and 20 kHz for 10 min) following a green method of synthesis. The EFPNs were incorporated at different levels [T0 (0%), T1 (1.0%), T2 (1.5%), and T3 (2.0%)] to impart bioactive properties to the Loct-Prot-based films which were used for packaging of white chocolate during 90 days tri...
Source: Ultrasonics Sonochemistry - September 15, 2023 Category: Chemistry Authors: Shubam Singh Hina F Bhat Sunil Kumar Rana Muhammad Aadil Maneesha S Mohan Charalampos Proestos Zuhaib F Bhat Source Type: research
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death
Mol Med Rep. 2023 Nov;28(5):202. doi: 10.3892/mmr.2023.13089. Epub 2023 Sep 15.ABSTRACTOsteoarthritis (OA) is a degenerative disease that ultimately leads to joint deformity. The pathogenesis of OA is believed to involve abnormal chondrocyte death, with ferroptosis serving a key role in chondrocyte damage. The present study investigated whether acetyl zingerone (AZ), a newly identified antioxidant derived from curcumin, can alleviate the progression of OA. To investigate this, the present study performed various experiments, including crystal violet staining, flow cytometry, immunofluorescence and western blot analysis. In...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Xu Chen Jie Chen Chunbao Miao Guangrong Yin Zhuangzhuang Zhang Rongbin Sun Su Ni Source Type: research
Enhancing stability of liposomes using high molecular weight chitosan to promote antioxidative stress effects and lipid-lowering activity of encapsulated lutein in vivo and in vitro
Int J Biol Macromol. 2023 Sep 13:126564. doi: 10.1016/j.ijbiomac.2023.126564. Online ahead of print.ABSTRACTLutein is an antioxidant with multiple beneficial functions. However, its therapeutic potential is hampered by its low water solubility and bioavailability. The goal of this study is to compare the stability of lutein-loaded liposomes (Lu-lip) and low (LC)/high molecular weight (HC) chitosan-coated Lu-lip, along with their antioxidant capacity using H2O2-induced HepG2 cells and their lipid-lowering activity using high-fat diet mice. Both LC and HC reduced the lutein degradation rate by 17.5 % and 26.72 % in a challen...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Gaoshuai Zhang Meijing Zhang Yiqiao Pei Kun Qian Jiao Xie Qun Huang Suwen Liu Na Xue Yujiao Zu Hao Wang Source Type: research
Enhanced mechanical and functional properties of chitosan/polyvinyl alcohol/hydroxypropyl methylcellulose/alizarin composite film by incorporating cinnamon essential oil and tea polyphenols
In this study, cinnamon essential oil and tea polyphenols were added to chitosan/ polyvinyl alcohol/ hydroxypropyl methylcellulose/ alizarin composite films to enhance their mechanical and functional properties. Their addition to the composite films enhanced their antibacterial and antioxidant properties and significantly improved its elongation at break (p < 0.05). Cinnamon essential oil reduced the water vapor permeability, water content, and water solubility of composite films and improved their transparency. The composite films with additive exhibited excellent UV-barrier ability and pH responsivity. Fourier Transfo...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Hongpeng Yu Qing Zhou Dong He JinJin Yang Kegang Wu Xianghua Chai Yujuan Xiang Xuejuan Duan Xiqin Wu Source Type: research
< em > Alpinia nelumboides < /em > Nob.Tanaka, T.T.K.Van & amp; V.Hoang: phytochemical analysis and antioxidant activities of pseudo-stem and rhizome essential oils
Nat Prod Res. 2023 Sep 15:1-7. doi: 10.1080/14786419.2023.2256021. Online ahead of print.ABSTRACTAlpinia nelumboides Nob.Tanaka, T.T.K.Van & V.Hoang is the new Alpninia species discovered in Vietnam in 2023. Herein, we first hydrodistillated its pseudo-stems and rhizomes to obtain its essential oils, PS-EO and RH-EO. Their volatile compounds and total polyphenols were analysed by gas chromatography-mass spectrometry and the Folin-Ciocalteu method, respectively. Antioxidant activities were determined using four different approaches. The results showed that PS-EO and RH-EO contained 40 and 31 compounds, accounting for 99...
Source: Natural Product Research - September 15, 2023 Category: Biochemistry Authors: Tuan Nguyen Hoang Hieu Tran-Trung Le Duc Giang Nguyen Thanh Triet Chen Tran Van Danh C Vu Anh Van Nguyen Nhi Nguyen Thanh To Khoa V A Nguyen Khoa Dang Nguyen Source Type: research
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways
Ageing Res Rev. 2023 Sep 13:102075. doi: 10.1016/j.arr.2023.102075. Online ahead of print.ABSTRACTParkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be increasing, reduced or unaffected. PRL level is dysregulated in different neurodegenerative disorders including PD. Preclinical and clinical studies pointed out that PRL may has a neuroprotective against PD neuropathology . Though, the mechanistic role of PRL in PD is not fully elucidated. Therefore, the objective of the present review was to clarify t...
Source: Ageing Research Reviews - September 15, 2023 Category: Genetics & Stem Cells Authors: Haydar M Al-Kuraishy Majid S Jabir Ali I Al-Gareeb Ali K Albuhadily Source Type: research
Natural Allies for Heart Health: Nrf2 Activation and Cardiovascular Disease Management
Curr Probl Cardiol. 2023 Sep 13:102084. doi: 10.1016/j.cpcardiol.2023.102084. Online ahead of print.ABSTRACTThe term "cardiovascular diseases" (CVD) refers to various ailments that affect the heart and blood vessels, including myocardial ischemia, congenital heart defects, heart failure, rheumatic heart disease, hypertension, peripheral artery disease, atherosclerosis, and cardiomyopathies. Despite significant breakthroughs in preventative measures and treatment choices, cardiovascular diseases (CVDs) significantly contribute to morbidity and mortality, imposing a considerable financial burden. Oxidative stress (OS) is a f...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Safir Ullah Khan Shahid Ullah Khan Muhammad Suleman Munir Ullah Khan Muhammad Sirab Khan Fawad Mueen Arbi Talib Hussain Source Type: research
Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research
Vitis Myb14 confer cold and drought tolerance by activating Lipid transfer protein genes expression and Reactive oxygen species scavenge
In this study, we investigate its role in abiotic stress tolerance. Significant differences in expression were observed between two grape varieties, Vitis amurensis (Cold-hardy) and V. vinifera (Cold-sentitive), under abiotic and hormone treatments. Both VvMyb14 and VaMyb14 demonstrated responsiveness to cold, drought and high salt treatment, but VaMyb14 exhibited a quicker and more pronounced response. To investigate further, we overexpressed VaMyb14 in A. thalina and found that VaMyb14 OE plants showed significantly enhanced cold and drought tolerance compared to wild-type plants. Additionally, the transgenic lines exhib...
Source: Gene - September 15, 2023 Category: Genetics & Stem Cells Authors: Linchuan Fang Zeming Wang Lingye Su Linzhong Gong Haiping Xin Source Type: research
Synthesis and evaluation of biological effects of modified graphene oxide nanoparticles containing Lawson (Henna extract) on gastric cancer cells
CONCLUSION: This study showed the efficacy of nanoparticles in inhibiting gastric cancer cells by relying on inhibiting angiogenesis.PMID:37715021 | DOI:10.1007/s11033-023-08797-4
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Mohammed Abdullah Hamdan Alkwedhim Vahid Pouresmaeil Fatemeh Davoodi-Dehaghani Mobina Mahavar Masoud Homayouni Tabrizi Source Type: research
The influence of atorvastatin, amlodipine and ethoxidol on ubiquinol and ubiquinone endogenous plasma concentrations in patients with chronic heart failure
CONCLUSION: Amlodipine is able to neutralize the negative effect of atorvastin on the redox balance of CoQ10 in patients with CHF. An additional prescription of the antioxidant ethoxidol to standard therapy for patients with CHF was substantiated. Determination of the redox state of CoQ10 in plasma can be used to diagnose and assess the degree of oxidative stress in patients with cardiovascular diseases, as well as to assess the efficacy and safety of ongoing pharmacotherapy.PMID:37711113 | DOI:10.2174/1389200224666230913133201
Source: Current Drug Metabolism - September 15, 2023 Category: Drugs & Pharmacology Authors: Vladlena I Zozina Svetlana N Kondratenko Evgenia V Shikh Liudmila M Krasnykh Evgeny S Melnikov Vladimir G Kukes Source Type: research
< em > Alpinia nelumboides < /em > Nob.Tanaka, T.T.K.Van & amp; V.Hoang: phytochemical analysis and antioxidant activities of pseudo-stem and rhizome essential oils
Nat Prod Res. 2023 Sep 15:1-7. doi: 10.1080/14786419.2023.2256021. Online ahead of print.ABSTRACTAlpinia nelumboides Nob.Tanaka, T.T.K.Van & V.Hoang is the new Alpninia species discovered in Vietnam in 2023. Herein, we first hydrodistillated its pseudo-stems and rhizomes to obtain its essential oils, PS-EO and RH-EO. Their volatile compounds and total polyphenols were analysed by gas chromatography-mass spectrometry and the Folin-Ciocalteu method, respectively. Antioxidant activities were determined using four different approaches. The results showed that PS-EO and RH-EO contained 40 and 31 compounds, accounting for 99...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Tuan Nguyen Hoang Hieu Tran-Trung Le Duc Giang Nguyen Thanh Triet Chen Tran Van Danh C Vu Anh Van Nguyen Nhi Nguyen Thanh To Khoa V A Nguyen Khoa Dang Nguyen Source Type: research
Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research
