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Drug: Methamphetamine

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Total 85 results found since Jan 2013.

Speed increases risk of stroke within hours or days of use
Methamphetamine can raise blood pressure, making users more susceptible to a hemorrhagic stroke, found a study by the University of New South Wales in Australia.
Source: the Mail online | Health - August 31, 2017 Category: Consumer Health News Source Type: news

Local experience with methamphetamine associated stroke at a small district health board.
Authors: Mahawish KM, Bowers A, DeCaigney S Abstract PMID: 30703785 [PubMed - in process]
Source: New Zealand Medical Journal - February 2, 2019 Category: General Medicine Tags: N Z Med J Source Type: research

Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Probable Nootropic-induced Psychiatric Adverse Effects: A Series of Four Cases
Conclusion Healthcare providers in general, and specifically those in the mental health and substance abuse fields, should keep in mind that nootropic use is an under recognized and evolving problem. Nootropic use should be considered in cases where there are sudden or unexplained exacerbations of psychiatric symptoms in patients who have been stable and medication adherent. It is also important to remember that most nootropics are not detected on standard drug toxicology screening tests. We have very little clinical information on how nootropics may interact with psychotropics (or other medications) and potentially cause ...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Series and Literature Review Current Issue Mental Disorders Psychiatry Psychopharmacology Substance Use Disorders Ampakines Armodafinil brain enhancer Cerebrolysin Citicoline cognitive enhancer homeopathic medicine natural r Source Type: research

Concurrent Myocardial and Cerebral Infarctions After Crystal Methamphetamine Use
Cardiac and cerebrovascular complications associated with methamphetamine abuse have been reported, but concurrent development of myocardial infarction and stroke is rare. A 33-year-old man presented with chest pain and right hemisphere stroke within 2 hours of methamphetamine use. Either cerebral vasoconstriction or cardiac source of embolism might be the cause of stroke.
Source: Neurosurgery Quarterly - April 29, 2015 Category: Neurosurgery Tags: Case Reports Source Type: research

Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders
AbstractNINJ2 encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer ’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While theNINJ2 rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs38...
Source: Journal of Molecular Neuroscience - December 22, 2019 Category: Neuroscience Source Type: research

Drugs of Misuse: Focus on Vascular Dysfunction
Can J Cardiol. 2022 Apr 21:S0828-282X(22)00261-6. doi: 10.1016/j.cjca.2022.04.011. Online ahead of print.ABSTRACTCommon drugs of misuse, including cannabis, opioids, stimulants, alcohol, and anabolic steroids, have strikingly disparate acute and chronic vascular effects, leading to a wide range of clinical cardiovascular presentations. Acute cannabis smoking has been associated with increased risk for myocardial infarction and ischemic stroke in otherwise healthy young people. However, it remains uncertain if people who exclusively smoke cannabis have increased risk for accelerated atherosclerosis similar to that found in ...
Source: Atherosclerosis - April 24, 2022 Category: Cardiology Authors: Holly R Middlekauff Ziva D Cooper Sasha B Strauss Source Type: research

The Impact of Marijuana Legalization on Reversible Cerebral Vasoconstriction Syndrome (P1.115)
Conclusions: RCVS can lead to serious health consequences, including death. It is unclear whether the increased RCVS secondary to marijuana is due to greater physician awareness of RCVS and marijuana use or to increased consumption after legalization. Regardless, RCVS and marijuana warrants further study.Disclosure: Dr. Wagner has received personal compensation for activities with Genentech, Inc., as a speakers bureau member. Dr. Leonard has nothing to disclose. Dr. Jensen has nothing to disclose. Dr. Farrell has nothing to disclose. Dr. Farrell has nothing to disclose. Dr. McCarthy has nothing to disclose. Dr. Bar-Or has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Wagner, J., Leonard, J., Jensen, J., Farrell, L., Jensen, A., McCarthy, K., Bar-Or, D. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

Chronic methamphetamine exposure prior to middle cerebral artery occlusion increases infarct volume and worsens cognitive injury in Male mice
Abstract Emerging evidence indicates that methamphetamine (MA) abuse can impact cardiovascular disease. In humans, MA abuse is associated with an increased risk of stroke as well as an earlier age at which the stroke occurs. However, little is known about how chronic daily MA exposure can impact ischemic outcome in either humans or animal models. In the present study, mice were injected with MA (10 mg/kg, i.p.) or saline once daily for 10 consecutive days. Twenty-four hours after the final injection, mice were subjected to transient middle cerebral artery occlusion (tMCAO) for one hour followed by reperfusion. M...
Source: Metabolic Brain Disease - July 6, 2016 Category: Neurology Source Type: research

UCLA Nursing research on women and heart disease among key topics at nursing conference
New findings on the role gender plays in the diagnosis, treatment and prevention of heart disease will be among the research topics highlighted by faculty members and students from the UCLA School of Nursing at the annual Western Institute of Nursing Conference, which runs from April 11 to 13 in Anaheim, Calif.   At a special state-of-the-science panel on Saturday, April 13, UCLA professor Lynn V. Doering will present a review of gender differences in identification, treatment and outcomes for cardiovascular disease, with a focus on coronary atherosclerosis, heart failure and stroke. During the same panel, UCLA profes...
Source: UCLA Newsroom: Health Sciences - April 9, 2013 Category: Universities & Medical Training Source Type: news

Methamphetamine dependent individuals show attenuated brain response to pleasant interoceptive stimuli
Conclusions: MD expend fewer brain processing resources during soft touch, a form of positively-valenced interoceptive stimuli, in brain areas that are important for both interoception and reward. Future studies will ascertain if sustained abstinence from methamphetamine use can normalize aberrant neural interoceptive processing.
Source: Drug and Alcohol Dependence - July 16, 2013 Category: Addiction Authors: April C. May, Jennifer L. Stewart, Robyn Migliorini, Susan F. Tapert, Martin P. Paulus Tags: Full Length Reports Source Type: research

Toxic lipstick, carbon monoxide tragedy, laundry detergent pod death: Weekly Web Review in Toxicology
Meth Labs and the Pharmaceutical Industry: Jonah Engle’s article in Mother Jones — “Merchants of Meth: How Big Pharma Keeps the Cooks in Business” — is compelling reading. The piece details how some drug companies lobbying firms are fighting efforts to control sale of the  meth precursor pseudoephedrine: As law enforcement agencies scramble to clean up and dispose of toxic [meth] labs, prosecute cooks, and find foster homes for their children, they are waging two battles: one against destitute, strong-out addicts, the other against some of the world’s wealthiest and most politically connected ...
Source: The Poison Review - August 21, 2013 Category: Toxicology Authors: Leon Tags: Medical big pharma carbon monoxide heavy metals laundry detergent pod methamphetamine toxic lipstick Source Type: news

In vivo evidence of methamphetamine induced attenuation of brain tissue oxygenation as measured by EPR oximetry.
This study investigated striatal tissue pO2 changes in male C57BL/6 mice (16-20g) following METH administration using EPR oximetry, a highly sensitive modality to measure pO2in vivo, in situ and in real time. We demonstrate that 20min after a single injection of METH (8mg/kg i.v.), the striatal pO2 was reduced to 81% of the pretreatment level and exposure to METH for 3 consecutive days further attenuated striatal pO2 to 64%. More importantly, pO2 did not recover fully to control levels even 24hrs after administration of a single dose of METH.and continual exposure to METH exacerbates the condition. We also show a reduction...
Source: Toxicology and Applied Pharmacology - January 8, 2014 Category: Toxicology Authors: Weaver J, Yang Y, Purvis R, Weatherwax T, Rosen GM, Liu KJ Tags: Toxicol Appl Pharmacol Source Type: research

Beta-blocker Use for Toxicity From “Bath Salts”
We appreciate the review of synthetic cathinones (“bath salts”) by Dr. Banks and colleagues (1). The long half-lives of these drugs are similar to methamphetamine, and persistent tachycardia and hypertension are problems that may lead to secondary injury such as acute coronary syndrome, heart failure, arterial dissection, and stroke (2–6). Indeed, the authors recognize this and write, “What is evident in these case reports is that tachycardia is more severe and more prevalent than hypertension; heart rates are commonly reported> 150 beats/min, whereas concomitant blood pressure (BP) might be normal or only mildly (systolic BP 
Source: The Journal of Emergency Medicine - November 18, 2014 Category: Emergency Medicine Authors: John R. Richards, Erik G. Laurin, Timothy E. Albertson Tags: Letter to the Editor Source Type: research

The Neuroprotective Potential of Low-Dose Methamphetamine in Preclinical Models of Stroke and Traumatic Brain Injury
Publication date: Available online 25 February 2015 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Thomas Rau , John Ziemniak , David Poulsen Methamphetamine is a psychostimulant that was initially synthesized in 1920. Since then it has been used to treat attention deficit hyperactive disorder (ADHD), obesity and narcolepsy. However, methamphetamine has also become a major drug of abuse worldwide. Under conditions of abuse, which involve the administration of high repetitive doses, methamphetamine can produce considerable neurotoxic effects. However, recent evidence from our laboratory i...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 25, 2015 Category: Psychiatry Source Type: research