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Quality improvement interventions to increase the uptake of magnesium sulphate in preterm deliveries for the prevention of cerebral palsy (PReCePT study): a cluster randomised controlled trial
CONCLUSIONS: PReCePT improved MgSO4 uptake in all maternity units. Enhanced support did not further improve uptake but may improve teamwork, and more accurately represented the time needed for implementation. Targeted enhanced support, sustainability of improvements and the possible indirect benefits of stronger teamwork associated with enhanced support should be explored further.PMID:37691262 | DOI:10.1111/1471-0528.17651
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 11, 2023 Category: OBGYN Authors: Hannah B Edwards Maria Theresa Redaniel Carlos Sillero-Rejon Christalla Pithara-McKeown Ruta Margelyte Tracey Stone Tim J Peters William Hollingworth Hugh McLeod Pippa Craggs Elizabeth M Hill Sabi Redwood Emma Treloar Jenny L Donovan Brent C Opmeer Karen Source Type: research

Comparison of Magnesium Status Using 24-h Urine Magnesium Content and Magnesium Fraction Excretion in PCOS with Non-PCOS Control Women: a Cross-sectional Study
This study is a cross-sectional analysis conducted at an academic medical center. Forty-four women were included in the PCOS group based on the Rotterdam criteria and 50 non-PCOS women were included in the control group. Statistical analysis of the relationship between 24-h urinary Mg content and FEMg, and also physical and metabolic variables, was performed. Main outcome measurements are 24-h urinary Mg content and FEMg. Mean values of 24-h urinary Mg content and FEMg did not significantly differ between PCOS and control groups (P = 0.22 and P = 0.24, respectively). Also, serum Mg levels and Ca/Mg ratio were similar betwe...
Source: Biological Trace Element Research - March 17, 2023 Category: Biology Authors: Saeed Abbasi Masoud Mohebbi Seyedeh Houra Mousavi Vahed Maliheh Dadgar Moghaddam Maliheh Afiat Mohsen Nematy Nafiseh Jahanpak Source Type: research

Hidden hydrogen: Earth may hold vast stores of a renewable, carbon-free fuel
IN THE SHADE of a mango tree, Mamadou Ngulo Konaré recounted the legendary event of his childhood. In 1987, well diggers had come to his village of Bourakébougou, Mali, to drill for water, but had given up on one dry borehole at a depth of 108 meters. “Meanwhile, wind was coming out of the hole,” Konaré told Denis Brière, a petrophysicist and vice president at Chapman Petroleum Engineering, in 2012. When one driller peered into the hole while smoking a cigarette, the wind exploded in his face. “He didn’t die, but he was burned,” Konaré continued. “And now we had a huge fire. The color of the fire...
Source: ScienceNOW - February 16, 2023 Category: Science Source Type: news

Factors associated with anti-seizure medication utilization for eclamptic seizures: 1995-2015
CONCLUSIONS: In this retrospective cohort, patients with atypical seizure presentation (e.g., postpartum and/or recurrent) and women who were comanaged with a neurologist were more likely to receive an ASM other than MgSO4.PMID:34600278 | DOI:10.1016/j.yebeh.2021.108299
Source: Epilepsy and Behaviour - October 2, 2021 Category: Neurology Authors: Gina M Deck Christina D Yarrington Page B Pennell Source Type: research

They ’re Healthy. They’re Sustainable. So Why Don’t Humans Eat More Bugs?
Sylvain Hugel is one of the world’s foremost experts on crickets of the Indian Ocean Islands. So when he received an email from a fellow entomologist in March 2017 asking for help identifying a species in Madagascar that could be farmed for humans to consume, he thought it was a joke. “I’m working to protect those insects, not eat them,” the French academic responded tartly. But the emails from Brian Fisher, an ant specialist at the California Academy of Sciences, in San Francisco, kept coming. Fisher had been doing fieldwork in Madagascar when he realized that the forests where both he and Hugel c...
Source: TIME: Science - February 26, 2021 Category: Science Authors: Aryn Baker Tags: Uncategorized Evergreen feature Londontime longform overnight Sustainability TIME 2030 Source Type: news

Zeolites as Carriers of Antitumor Ribonuclease Binase
In this study we tested the clinoptilolite, chabazite, and natrolite ability to be loaded by antitumor ribonuclease binase and the cytotoxicity of the obtained complexes. We found the optimal conditions for binase loading into zeolites and established the dynamic of its release. Cytotoxic effects of zeolite-binase complexes toward colorectal cancer Caco2 cells were characterized after 24 and 48 h of incubation with cells using MTT-test. Zeolites were toxic by itselfs and reduced cells viability by 30% (clinoptilolite), 40% (chabazite), and 70% (natrolite) after 48 h of incubation. Binase complexes with clinoptilolite as we...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing
In conclusion, the method of NK cell transfection described in our present study is highly efficient, does not require expensive dedicated structures necessary for viral transduction and avoids possible risks associated with the use of viral vectors. Importantly, it may be applied to NK cells or NK-92 cell line, greatly improving their anti-tumor activity and providing a new NK cell-based platform for new protocols of adoptive immuno-therapy of cancer. Ethics Statement The Ethical Committee of IRCCS Bambino Gesù Pediatric Hospital approved the study (825/2014). Author Contributions TI designed and performed res...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

A Rapid Antimicrobial Susceptibility Test for Determining Yersinia pestis Susceptibility to Doxycycline by RT-PCR Quantification of RNA Markers
This study was supported by the Israel Institute for Biological Research, Ness Ziona, Israel. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We thank Dr. Vered Caspi (Ben-Gurion University) for assisting with the bioinformatics and statistical analyses of the Agilent DNA microarray results. Supplementary Material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00754/full#s...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study
Conclusions: Elevated prenatal W-Mn exposure was positively associated with cognitive function in girls, whereas boys appeared to be unaffected. Early life W-Mn exposure appeared to adversely affect childrens behavior. https://doi.org/10.1289/EHP631 Received: 19 January 2016 Revised: 08 June 2016 Accepted: 23 June 2016 Published: 26 May 2017 Corresponding author: Address correspondence to M. Kippler, Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-171 77, Stockholm, Sweden. Telephone: +46 8 524 87407, Fax: +468336981, E-mail: maria.kippler@ki.se Supplemental Material is available on...
Source: EHP Research - May 26, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

LITFL Review – Best of 2015
Welcome to the Best of 2015 LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM. The Most Fair Dinkum Ripper Beauts of the Year SMACC Podcast: Crack the Chest Get Crucified (John Hinds) John’s talk from the opening plenary at SMACC Chicago had a furious battle with David Newman’s talk for the number one spot. Both were clear front runners given the shear numb...
Source: Life in the Fast Lane - January 8, 2016 Category: Emergency Medicine Authors: Anand Swaminathan Tags: Education LITFL review Source Type: blogs

Aloe vera for prevention and treatment of infusion phlebitis.
CONCLUSIONS: There is no strong evidence for preventing or treating infusion phlebitis with external application of Aloe vera. The current available evidence is limited by the poor methodological quality and risk of selective outcome reporting of the included studies, and by variation in the size of effect across the studies. The positive effects observed with external application of Aloe vera in preventing or treating infusion phlebitis compared with no intervention or external application of 33% or 50% MgSO4 should therefore be viewed with caution. PMID: 24895299 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 4, 2014 Category: Journals (General) Authors: Zheng GH, Yang L, Chen HY, Chu JF, Mei L Tags: Cochrane Database Syst Rev Source Type: research