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Bence Jones Island in Shepherd Bay, Ninavut: a little known tribute to the legendary physician and chemist's "th é de voyage"
Haematologica. 2022 Aug 18. doi: 10.3324/haematol.2022.281864. Online ahead of print.ABSTRACTHenry Bence Jones is among the esteemed physicians of the mid-19th century. Eighteen biographical medical journal articles, published between 1952 and 2021, describe his life and contributions to medicine. Unmentioned, however, is an island in the waters of Shepherd Bay in northern Canada, now Nunavut, designated Bence Jones Island, by the British explorer John Rae in 1854. Rae had sailed from Great Britain to the regions extending north of Hudson's Bay in search of information regarding Sir John Franklin and 133 other officers and...
Source: Haematologica - August 18, 2022 Category: Hematology Authors: Marshall A Lichtman Edward M Reading Source Type: research

A Meta-Analysis of the Effects of Foam Rolling on Performance and Recovery
Conclusion In conclusion, this meta-analysis illustrates that pre-rolling seems to be an effective strategy for short-term improvements in flexibility without decreasing muscle performance. The review has also shown that the improvement of sprint performance to be expected from the use of pre-rolling, as well as the recovery rate of the performance measures of speed and strength with post-rolling, are significant enough to be relevant for at least elite athletes. The underlying mechanisms, however, remain elusive and the effects are in part contradictory. While the effects of FR on muscle function were less clear, the pos...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research

Treatment-Resistant to Antipsychotics: A Resistance to Everything? Psychotherapy in Treatment-Resistant Schizophrenia and Nonaffective Psychosis: A 25-Year Systematic Review and Exploratory Meta-Analysis
Conclusions: CBT, psychosocial intervention, supportive counseling, psychodynamic psychotherapy, and other psychological interventions can be recommended for clinical practice. More studies are needed, especially for non-CBT interventions and for all psychotherapies on negative symptoms.IntroductionSchizophrenia affects approximately 1% of the population, usually starting in adolescence or young adulthood, frequently leading to persistent disability, with a high risk of suicide (8%). Despite the advance in antipsychotics treatment, approximately 30% of patients with schizophrenia show a poor response or no response to anti...
Source: Frontiers in Psychiatry - April 16, 2019 Category: Psychiatry Source Type: research

Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome
In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating th...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

Inhaled nitric oxide for treating pain crises in people with sickle cell disease
CONCLUSIONS: The currently available evidence is insufficient to determine the effects (benefits or harms) of using inhaled nitric oxide to treat pain (vaso-occlusive) crises in people with sickle cell disease. Large-scale, long-term trials are needed to provide more robust data in this area. Patient-important outcomes (e.g. measures of pain and time to pain resolution and amounts of analgesics used), as well as use of healthcare services, should be measured and reported in a standardised manner.PMID:35802341 | PMC:PMC9266993 | DOI:10.1002/14651858.CD011808.pub3
Source: Cochrane Database of Systematic Reviews - July 8, 2022 Category: General Medicine Authors: Tarek Aboursheid Omar Albaroudi Fares Alahdab Source Type: research

National healthcare-associated infections surveillance programs: A scoping review
CONCLUSION: Most countries analyzed have HAI surveillance programs, with characteristics varying by country. Patient-level data reporting with numerators and denominators is available for almost every surveillance program, allowing for reporting of incidence rates and more refined benchmarks, specific to a given healthcare category thus offering data that can be used to measure, monitor, and improve the incidence of HAIs.PMID:37416111 | PMC:PMC10322113 | DOI:10.14745/ccdr.v48i78a05
Source: Can Commun Dis Rep - July 7, 2023 Category: Infectious Diseases Authors: Etienne Poirier Virginie Boulanger Anne MacLaurin Caroline Quach Source Type: research

Computer screening for palliative care needs in primary care: a mixed-methods study.
CONCLUSION: GP practices can use computer searching to generate lists of patients for review and care planning. The challenges of starting a conversation about the future remain. However, most patients regard key components of palliative care (proactive planning, including sharing information with urgent care services) as important. Screening for people with deteriorating health at risk from unplanned care is a current focus for quality improvement and should not be limited by labelling it solely as 'palliative care'. PMID: 29581129 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - March 26, 2018 Category: Primary Care Authors: Mason B, Boyd K, Steyn J, Kendall M, Macpherson S, Murray SA Tags: Br J Gen Pract Source Type: research

The Promotion of ‘Grab Bags’ as a Disaster Risk Reduction Strategy
Conclusion The results of this study identified gaps in the evidence on the effectiveness of grab bags, and found variations in guidelines and promotion practices across different countries. With the implementation of the Sendai Framework and its emphasis on an all-of-society approach to DRR1, there is an opportunity to raise widespread awareness of the importance of household preparedness. Grab bags are recognized as an important strategy to support DRR, however the need for an evidence base must be addressed to support investments in this area. 7.0 Appendix Table 2: Embase search strategy # Searches Results ...
Source: PLOS Currents Disasters - July 6, 2018 Category: International Medicine & Public Health Authors: Christina J. Pickering Source Type: research

Geographical Variations in Prostate Cancer Outcomes: A Systematic Review of International Evidence
Conclusions: This review found substantial evidence that prostate cancer indicators varied by residential location across diverse populations and geographies. While wide variations in study design limited comparisons across studies, our review indicated that internationally, men living in disadvantaged areas, and to a lesser extent more rural areas, face a greater prostate cancer burden. This review highlights the need for a better understanding of the complex social, environmental, and behavioral reasons for these variations, recognizing that, while important, geographical access is not the only issue. Implementing resear...
Source: Frontiers in Oncology - April 7, 2019 Category: Cancer & Oncology Source Type: research

Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants
Conclusion Genomic analyses herein performed allowed us to confirm the recently (Pérez-Cataluña et al., 2018a,b) suggested amendment of A. butzleri as Al. butzlerii, comb. nov. Antimicrobial susceptibility tests defined Ab 55 and Ab 6V strains as resistant to vancomycin, tetracyclin, nalidixic acid (only Ab 55 whereas Ab 6V is intermediate resistant), erythromycin, and β-lactam antibiotics. Moreover, in our strains isolated from shellfish, we identified numerous virulence, antibiotic, and heavy metal resistance determinants, also additional to those previously found in the genome sequenced A. butzler...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Diagnosis, Phenotype, and Molecular Genetics of Congenital Analbuminemia
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Surveillance and Genomics of Toxigenic Vibrio cholerae O1 From Fish, Phytoplankton and Water in Lake Victoria, Tanzania
This study reports the occurrence of multidrug resistant V. cholerae O1 in Lake Victoria that are genetically closely related to recent pandemic strains in Tanzania, Kenya and Uganda. The strains identified are also closely related to older pandemic strains recovered in the Democratic Republic of Congo, Burundi and Tanzania up until 1993, suggesting a long-term persistence and wide spatial distribution of pandemic strains within the region with the lake serving as a reservoir. These environmental isolates likely emerged from previous cholera outbreaks and survived in the lake environment for decades through various relatio...
Source: Frontiers in Microbiology - April 29, 2019 Category: Microbiology Source Type: research