Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome

In conclusion, we unraveled the secretome of G. adiacens, an oral bacterium well-documented in infective endocarditis, but also recently shown to be involved in oral infections. Importantly, the secretome of G. adiacens comprised of a large number of putative virulence factors. Of particular importance is the finding that the G. adiacens secretome comprised of a number of “moonlighting” proteins, which in other species are shown to enhance bacterial colonization and virulence through their multifunctional roles (Pavkova et al., 2017; Graf et al., 2019). Thus, our results provide a basis for investigating the role of secreted proteins of G. adiacens in oral infections as well as in infective endocarditis. Data Availability Mass spectrometry data has been submitted to “PRIDE Archive” (https://www.ebi.ac.uk/pride/archive/) repository with the project accession number PXD013000. The data files can be accessed with the username: reviewer53961@ebi.ac.uk and password: VmJUzTGl. Ethics Statement This study was carried out in accordance with the recommendations of the Ethical Committee of Health Sciences Center (HSC), Kuwait University. Written informed consent was obtained from the human volunteer and the consent was in accordance with the Declaration of Helsinki. The protocol was approved by the Ethical Committee of the HSC, Kuwait University. Author Contributions MK conceived and designed the study, bioinformatics analyses. RB and MK performed the labo...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

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