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Education: Academia
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Fractional exhaled nitric oxide (FeNO) among office workers in an academic institution, Malaysia - associations with asthma, allergies and office environment.
CONCLUSION: Gender, smoking, height and atopy are important risk factors for elevated FeNO levels. A combination of allergy testing and FeNO measurement could be useful in respiratory illness epidemiology studies and patient investigations in tropical areas.
PMID: 26300213 [PubMed - as supplied by publisher]
Source: Journal of Asthma - February 18, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research
Abstract 004: Electronic Health Record-Based Overestimation of Failure to Prescribe Statins in Patients With Coronary Artery Disease in a Large, Academic, Multispecialty Clinic Practice Session Title: Abstract Oral Session: QCOR 2017 Young Investigator Award Finalists
Conclusions: Among outpatients with presumed CAD who were identified by EHR data query as "failures" to receive statin prescriptions, an estimated fewer than one-third constituted a true gap in care. These findings raise concern about the accuracy of EHR data query in measuring performance in the Meaningful Use era.
Source: Circulation: Cardiovascular Quality and Outcomes - March 31, 2017 Category: Cardiology Authors: Shin, E. Y., Ochuko, P., Bhatt, K., Howard, B., McGorisk, G., Delaney, L., Langdon, K., Khosravanipour, M., Nambi, A., Grahovec, A., Morris, D., Castellano, P., Shaw, L., Sperling, L., Goyal, A. Tags: Session Title: Abstract Oral Session: QCOR 2017 Young Investigator Award Finalists Source Type: research
LJI research lab wins Best Academic Research Team Award
(La Jolla Institute for Allergy and Immunology) Dr. Alessandro Sette's team at La Jolla Institute for Allergy and Immunology has been named Best Academic Research Team as part of the 10th Vaccine Industry Excellence Awards at this year's World Vaccine Congress 2017 held in Washington. The ViE Awards celebrate the outstanding contributions and achievements of leaders who continually set standards of excellence and advocacy in vaccine development.
Source: EurekAlert! - Biology - April 14, 2017 Category: Biology Source Type: news
Triggers of oral lichen planus flares and the potential role of trigger avoidance in disease management
Conclusions Trigger identification and avoidance can play a potentially effective role in the management of OLP.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - May 30, 2017 Category: ENT & OMF Source Type: research
The Florence Statement on Triclosan and Triclocarban
Author Affiliations open
1Biodesign Center for Environmental Security, Arizona State University, Tempe, Arizona, USA
2Green Science Policy Institute, Berkeley, California, USA
3Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
4Environmental Working Group, Washington, District of Columbia, USA
5Department of Civil, Environmental, and Geo-Engineering, University of Minnesota, Minneapolis, Minnesota, USA
6Medical University of South Carolina, Department of Public Health Sciences, Charleston, South Carolina, USA
7Health Research Communicati...
Source: EHP Research - June 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Brief Communication Source Type: research
Etiology and Management of Allergic Eyelid Dermatitis
Conclusions: Allergic eyelid dermatitis is commonly related to eye drops and topical cosmetics or skin care products. Identification and elimination of causative agents is the mainstay of management. Topical corticosteroids often facilitate resolution of the associated inflammation. Therapy resistant patients may benefit from formal allergy testing.
Source: Ophthalmic Plastic and Reconstructive Surgery - July 1, 2017 Category: Opthalmology Tags: Original Investigations Source Type: research
Weekly Personal Ozone Exposure and Respiratory Health in a Panel of Greek Schoolchildren
Conclusions:
The study provides evidence that airway inflammation and the frequency of respiratory symptoms increase, whereas lung function decreases with increased ozone exposure in schoolchildren. https://doi.org/10.1289/EHP635
Received: 09 June 2016
Revised: 08 March 2017
Accepted: 13 March 2017
Published: 21 July 2017
Please address correspondence to A. Karakatsani, 2nd Pulmonary Department, ATTIKON University Hospital, School of Medicine, National and Kapodistrian University of Athens, 1, Rimini St., 124 62 Haidari, Greece. Telephone: 30-210-5831184. Email: annakara@otenet.gr, akarakats@med.uoa.gr
The authors de...
Source: EHP Research - July 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research
NIAID and Children's National partner to advance pediatric clinical research
(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and Children's National Health System, a pediatric academic medical center in Washington, D.C., have launched a clinical research partnership devoted to treating and preventing allergic, immunologic and infectious diseases in children. An inaugural symposium will take place at Children's National on Sept. 17, 2018, to highlight the partnership and discuss current and future directions for its research activities.
Source: EurekAlert! - Medicine and Health - September 17, 2018 Category: International Medicine & Public Health Source Type: news
Academic performance of urban children with asthma worse than peers without asthma
(American College of Allergy, Asthma, and Immunology) A new study published in Annals of Allergy, Asthma and Immunology shows urban children with poorly controlled asthma, particularly those who are ethnic minorities, also suffer academically. Kids who were kept home due to asthma symptoms weren't able to do as well in the classroom.
Source: EurekAlert! - Medicine and Health - March 11, 2019 Category: International Medicine & Public Health Source Type: news
Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion
Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases.
Author Contributions
HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research
Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction
We describe the unexpected binding of S-layer to cells devoid of DC-SIGN but also confirm that the presence of DC-SIGN was essential for S-layer’s antiviral activity. S-layer protein exerted its antiviral effect with different kinetics than mannan, a known viral inhibitor that also acts on DC-SIGN (Yu et al., 2017). Together our results suggest that inhibition of viral entry by S-layer occurs via a novel S-layer/DC-SIGN interaction.
Materials and Methods
Isolation of S-Layer Proteins
S-layer proteins were extracted from overnight cultures of L. acidophilus ATCC 4356 cells grown in MRS medium at 37°C by usi...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research
The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research
The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations.
Introduction
Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influen...
Source: Frontiers in cellular and infection microbiology - April 16, 2019 Category: Microbiology Source Type: research
Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs
This study was supported by NIH/NIAID grants R01AI102766 (YL), P01AI104722 (RW and YL), UM1 AI100663 (RW), and Bill and Melinda Gates Foundation grant OPP1084519 (RW). JS is a trainee of NIH training grant T32AI125186A to Anne Simon at University of Maryland, College Park. This study was also partially funded by the International AIDS Vaccine Initiative (IAVI) (RW) with the generous support of United States Agency for International Development (USAID), and Ministry of Foreign Affairs of the Netherlands.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or ...
Source: Frontiers in Microbiology - April 22, 2019 Category: Microbiology Source Type: research
A Novel Nonsense Mutation in FERMT3 Causes LAD-III in a Pakistani Family
Conclusion
In conclusion, this study wants to stress the importance of early diagnosis. As in the majority of primary immunodeficiency diseases, the prognosis of LAD3 is extremely dependent on early age diagnosis, with timely management of bacterial infections and consideration for HSCT. In addition, this autosomal recessive disorder has high incidence in areas with high rate of consanguineous marriages. Therefore, broadening the spectrum of known mutations underlying the phenotype of such a life-threatening disease can help offering and performing better genetic counseling and prenatal diagnosis.
Ethics Statement
This ...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research
