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Specialty: Endocrinology
Condition: Hypertension
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Total 255 results found since Jan 2013.
H‐Type hypertension, stroke and diabetes in China: Opportunities for primary prevention / H型高血压,脑卒中和糖尿病:中国人群一级预防的机遇
1969年,McCully 首次发现同型半胱氨酸水平即使轻度升高也可加速动脉粥样硬化的发展,由此提出“同型半胱氨酸‐动脉粥样硬化学说”1。接下来的一些前瞻性队列研究提出,同型半胱氨酸水平每降低3 µmol/L可以使脑卒中风险下降24%2。然而,考察降低同型半胱氨酸治疗对脑卒中影响的一些随机、对照临床研究并未观察到明确的结果3。需要注意的是,流行病学研究与临床试验存在诸多重要的不同之处。一般队列研究多关注相对健康人群,而大多数临床研究入组的则是患有心脑血管疾病...
Source: Journal of Diabetes - November 4, 2015 Category: Endocrinology Authors: Xianhui Qin, Yong Huo Tags: Commentary ‐ by Invitation Only Source Type: research
A Statistical Analysis of a Traffic-Light Food Rating System to Promote Healthy Nutrition and Body Weight
Conclusion:
The food rating color-coded system identifies food items with superior nutrition, and lower caloric density. The smartphone app, incorporating the system, has the potential to improve nutrition; reduce the risk of developing diabetes, hypertension, heart disease, and stroke; and improve public health.
Source: Journal of Diabetes Science and Technology - October 30, 2015 Category: Endocrinology Authors: Larrivee, S., Greenway, F. L., Johnson, W. D. Tags: Obesity Technology Source Type: research
Sex hormones and ischemic stroke: a prospective cohort study and meta-analyses.
CONCLUSIONS: Extreme low endogenous testosterone concentrations were associated with high risk of IS in men, a risk mediated in part by body mass index and hypertension. Whether or not low testosterone is a causal factor for IS or merely a biomarker of poor metabolic health is still not known.
PMID: 26509870 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2015 Category: Endocrinology Authors: Holmegard HN, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A, Benn M Tags: J Clin Endocrinol Metab Source Type: research
Effect of folic acid supplementation on risk of new‐onset diabetes in adults with hypertension in China: Findings from the CSPPT
ConclusionsAmong adults with hypertension with no history of stroke and/or MI in China, folic acid supplementation had no significant effect on the risk of new‐onset diabetes. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes - October 11, 2015 Category: Endocrinology Authors: Xianhui Qin, Jianping Li, Yan Zhang, Dafang Chen, Binyan Wang, Mingli He, Jia Fu, Genfu Tang, Yefeng Cai, Xiuli Shi, Xin Xu, Fan Fan Hou, Xiaobin Wang, Yong Huo Tags: Original Article Source Type: research
Diabetes mellitus related biomarker: the predictive role of growth-differentiation factor-15
Publication date: Available online 9 October 2015 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Alexander E. Berezin Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - October 10, 2015 Category: Endocrinology Source Type: research
Evidence-Based Guideline of the German Nutrition Society: Fat Intake and Prevention of Selected Nutrition-Related Diseases.
Abstract
As nutrition-related chronic diseases have become more and more frequent, the importance of dietary prevention has also increased. Dietary fat plays a major role in human nutrition, and modification of fat and/or fatty acid intake could have a preventive potential. The aim of the guideline of the German Nutrition Society (DGE) was to systematically evaluate the evidence for the prevention of the widespread diseases obesity, type 2 diabetes mellitus, dyslipoproteinaemia, hypertension, metabolic syndrome, coronary heart disease (CHD), stroke, and cancer through the intake of fat or fatty acids. The main res...
Source: Diabetes Metab - October 1, 2015 Category: Endocrinology Authors: Wolfram G, Bechthold A, Boeing H, Ellinger S, Hauner H, Kroke A, Leschik-Bonnet E, Linseisen J, Lorkowski S, Schulze M, Stehle P, Dinter J Tags: Ann Nutr Metab Source Type: research
Social Determinants of Health in Adults with Type 2 Diabetes–Contribution of Mutable and Immutable Factors
Type 2 diabetes affects more than 29 million people in the US, with an estimated 8.1 million individuals having undiagnosed type 2 diabetes and an estimated 86 million Americans diagnosed with prediabetes [1]. In 2012, costs associated with type 2 diabetes totaled $245 billion, including direct and indirect costs [1]. The remarkable cost of type 2 diabetes can be attributed to various complications and comorbid conditions associated with this chronic illness, including hypo- and hyperglycemia, high blood pressure, high LDL cholesterol, heart disease, stroke, blindness, kidney disease, and amputations [1].
Source: Diabetes Research and Clinical Practice - September 17, 2015 Category: Endocrinology Authors: Rebekah J. Walker, Brittany L. Smalls, Leonard E. Egede Source Type: research
Social determinants of health in adults with type 2 diabetes—Contribution of mutable and immutable factors
Type 2 diabetes affects more than 29 million people in the US, with an estimated 8.1 million individuals having undiagnosed type 2 diabetes and an estimated 86 million Americans diagnosed with prediabetes [1]. In 2012, costs associated with type 2 diabetes totaled $245 billion, including direct and indirect costs [1]. The remarkable cost of type 2 diabetes can be attributed to various complications and comorbid conditions associated with this chronic illness, including hypo- and hyperglycemia, high blood pressure, high LDL cholesterol, heart disease, stroke, blindness, kidney disease, and amputations [1].
Source: Diabetes Research and Clinical Practice - September 17, 2015 Category: Endocrinology Authors: Rebekah J. Walker, Brittany L. Smalls, Leonard E. Egede Source Type: research
Sex-Specific Differential in Risk of Diabetes-Related Macrovascular Outcomes
In conclusion, diabetes is associated with a slightly higher risk of cardiovascular disease in women compared to men. Future studies should further explore the reasons underlying imperfect use of medications that lower cardiovascular risk in both women and men with diabetes.
Source: Current Diabetes Reports - September 14, 2015 Category: Endocrinology Source Type: research
H‐type hypertension, stroke and diabetes in China: Opportunities for primary prevention
Abstract
In summary, the CSPPT, with its large sample size and unique study design has provided a definitive answer regarding the role of folic acid supplementation in conjunction with anti‐hypertension therapy in the primary prevention of stroke. Further studies are needed to examine the joint effect of anti‐hypertensive treatment and folic acid supplementation on the development or progression of T2DM as well as vascular complications, particularly in populations without folic acid fortification. If these relationships can be established and underlying mechanisms elucidated, the implications for clinical and public h...
Source: Journal of Diabetes - September 1, 2015 Category: Endocrinology Authors: Xianhui Qin, Yong Huo Tags: Original Article Source Type: research
Cost-Effectiveness Analysis of the Diagnosis and Treatment of Primary Aldosteronism in Japan
We examined whether diagnosing and treating hidden PA in hypertensive population was cost-effective compared with suboptimal treatment. Our hypothetical patient was a 50-year-old man diagnosed with stage I–III hypertension. We established a Markov decision model based on plausible clinical pathways and prognoses of PA. We applied cost-effectiveness analysis comparing a comprehensive diagnostic strategy for PA (measurement of plasma aldosterone/renin ratio, 2 loading tests, imaging, and selective adrenal venous sampling) with a suboptimal strategy to manage hypertension by medication unless the typical signs of PA or othe...
Source: Hormone and Metabolic Research - August 25, 2015 Category: Endocrinology Authors: Sato, M.Morimoto, R.Seiji, K.Iwakura, Y.Ono, Y.Kudo, M.Satoh, F.Ito, S.Ishibashi, T.Takase, K. Tags: Endocrine Care Source Type: research
Sleep apnea syndrome in endocrine clinics
Abstract
Obstructive sleep apnea syndrome (OSAS) is a chronic condition with a high prevalence (up to 7 % of the general population) characterized by frequent episodes of upper airway collapse while sleeping. Left untreated, OSAS can cause severe complications, including systemic hypertension, cardiovascular disease, stroke, and abnormal glucose metabolism. This review aims to summarize the close links between OSAS, endocrinology, and metabolism. In patients with metabolic syndrome, OSAS is an independent risk factor for the onset of type 2 diabetes and a worsening glycemic control. The accumulation of adipose ti...
Source: Journal of Endocrinological Investigation - June 30, 2015 Category: Endocrinology Source Type: research
Diabetes, hypertension and stroke - does Alzheimer protect you?
CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of Alzheimer's disease.
PMID: 25702297 [PubMed - indexed for MEDLINE]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data
Publication date: Available online 28 May 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Kunihiro Matsushita , Josef Coresh , Yingying Sang , John Chalmers , Caroline Fox , Eliseo Guallar , Tazeen Jafar , Simerjot K Jassal , Gijs W D Landman , Paul Muntner , Paul Roderick , Toshimi Sairenchi , Ben Schöttker , Anoop Shankar , Michael Shlipak , Marcello Tonelli , Jonathan Townend , Arjan van Zuilen , Kazumasa Yamagishi , Kentaro Yamashita , Ron Gansevoort , Mark Sarnak , David G Warnock , Mark Woodward , Johan Ärnlöv Background The usefulness of estimated glomerular filtration rate (eGFR) and albumin...
Source: The Lancet Diabetes and Endocrinology - May 30, 2015 Category: Endocrinology Source Type: research
Normocalcaemic, vitamin D sufficient hyperparathyroidism ‐ high prevalence and low morbidity in the general population A long‐term follow‐up study, the WHO MONICA project, Gothenburg, Sweden
ConclusionsThis small random population study showed that nHPT was common, 11% at follow‐up. Only one individual developed mild hypercalcaemia in 13 years. Previous S‐PTH was predictive of nHPT and hypertension was prevalent, but no increase in hard end points was seen over a 17‐year period.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - May 18, 2015 Category: Endocrinology Authors: Georgios Kontogeorgos, Penelope Trimpou, Christine M. Laine, Göran Oleröd, Anders Lindahl, Kerstin Landin‐Wilhelmsen Tags: Rapid Communication Source Type: research
