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Condition: Ischemic Stroke
Drug: Losartan

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Total 18 results found since Jan 2013.

Electrocardiographic left atrial abnormalities and risk of incident stroke in hypertensive patients with electrocardiographic left ventricular hypertrophy
Conclusion: Abnormal PTFV1, a marker of left atrial abnormality, was strongly associated with incident stroke in hypertensive patients, independent of in-treatment SBP and other predictors of incident stroke. This association, in the absence of detectable atrial fibrillation, suggests that an underlying atrial cardiopathy may cause left atrial thrombus formation and a subsequent stroke without intervening clinically recognized atrial fibrillation.
Source: Journal of Hypertension - August 5, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research

Mitral Annular Calcification and Incident Ischemic Stroke in Treated Hypertensive Patients: The LIFE study.
ConclusionsMAC is common in treated hypertensive patients with ECG LVH and is an independent predictor of incident ischemic stroke. PMID: 23391619 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - February 7, 2013 Category: Cardiology Authors: De Marco M, Gerdts E, Casalnuovo G, Migliore T, Wachtell K, Boman K, Dahlöf B, Olsen MH, Kizer JR, Devereux RB, de Simone G Tags: Am J Hypertens Source Type: research

Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension Basic Sciences
Conclusions— Impaired neurovascular coupling in the SHR evolves upon sustained hypertension. Antihypertensive monotherapy using verapamil or losartan is not sufficient to abolish this functional impairment. These deficits in neurovascular coupling in response to sustained hypertension might contribute to accelerate progression of neurodegenerative diseases in chronic hypertension.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Calcinaghi, N., Wyss, M. T., Jolivet, R., Singh, A., Keller, A. L., Winnik, S., Fritschy, J.-M., Buck, A., Matter, C. M., Weber, B. Tags: Animal models of human disease, Brain Circulation and Metabolism, Other imaging Basic Sciences Source Type: research

Hemilingual Angioedema after Thrombolysis in a Patient on an Angiotensin II Receptor Blocker
We report a case of a 60-year-old male presenting with hyperacute ischemic stroke developing hemilingual edema after thrombolysis. He was previously maintained on an angiotensin II receptor blocker (ARB), losartan. The swelling resolved over 2 days with immediate administration of intravenous steroids and antihistamine drugs.
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Jose Danilo Bengzon Diestro, Lady Scarlette Pacsi Sedano, Nikolai Gil Diwa Reyes, Maria Cristina Zarsadias San Jose Tags: Case Report Source Type: research

Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.
Abstract Patients with hypertension have a high risk of ischemic stroke and subsequent stroke-associated pneumonia. Stroke-associated pneumonia is most likely to develop in patients with dysphagia. The present study was designed to compare the ameliorative effects of different treatments in rat model of dysphagia. Spontaneously hypertensive rats were treated with bilateral common carotid artery occlusion (BCAO) to induce chronic cerebral hypoperfusion causing disorders of the swallowing reflex. Angiotensin-converting enzyme (ACE) inhibitors (perindopril, imidapril and enalapril), an angiotensin II type 1-receptor ...
Source: European Journal of Pharmacology - November 12, 2014 Category: Drugs & Pharmacology Authors: Ikeda JI, Kojima N, Saeki K, Ishihara M, Takayama M Tags: Eur J Pharmacol Source Type: research

Probable Nootropic-induced Psychiatric Adverse Effects: A Series of Four Cases
Conclusion Healthcare providers in general, and specifically those in the mental health and substance abuse fields, should keep in mind that nootropic use is an under recognized and evolving problem. Nootropic use should be considered in cases where there are sudden or unexplained exacerbations of psychiatric symptoms in patients who have been stable and medication adherent. It is also important to remember that most nootropics are not detected on standard drug toxicology screening tests. We have very little clinical information on how nootropics may interact with psychotropics (or other medications) and potentially cause ...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Series and Literature Review Current Issue Mental Disorders Psychiatry Psychopharmacology Substance Use Disorders Ampakines Armodafinil brain enhancer Cerebrolysin Citicoline cognitive enhancer homeopathic medicine natural r Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Relationship of Sudden Cardiac Death to New-Onset Atrial Fibrillation in Hypertensive Patients With Left Ventricular Hypertrophy Original Articles
Conclusions— Development of new-onset AF identifies hypertensive patients at increased risk of SCD. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00338260.
Source: Circulation: Arrhythmia and Electrophysiology - April 16, 2013 Category: Cardiology Authors: Okin, P. M., Bang, C. N., Wachtell, K., Hille, D. A., Kjeldsen, S. E., Dahlof, B., Devereux, R. B. Tags: Clinical Studies, Arrhythmias, clinical electrophysiology, drugs, Epidemiology Original Articles Source Type: research

Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation
Conclusion: In hypertensive patients with ECG left ventricular hypertrophy with existing or new atrial fibrillation, digoxin use is not associated with a significantly increased risk of all-cause mortality after adjusting for other independent predictors of death and for the factors associated with the propensity to use digoxin in this population. These findings suggest that factors other than digoxin use may account for the increased mortality found with digoxin use in some studies. Clinical Trials Registration: http://clinicaltrials.gov/ct/show/NCT00338260?order=1
Source: Journal of Hypertension - June 5, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Fimasartan: A New Angiotensin Receptor Blocker
Abstract Fimasartan is the ninth, and most recent, angiotensin II receptor antagonist approved as an antihypertensive agent. Fimasartan, a pyrimidin-4(3H)-one derivative of losartan with the imidazole ring replaced, which enables higher potency and longer duration than losartan. Fecal elimination and biliary excretion are the predominant elimination pathways of fimasartan and the urinary excretion was found to be less than 3 % 24 h after administration. Fimasartan is primarily catabolized by cytochrome P450 isoform 3A and no significant drug interaction was observed when used in combination with hydrochlorothia...
Source: Drugs - June 6, 2016 Category: Drugs & Pharmacology Source Type: research

Pattern of antihypertensive therapy among diabetic hyperten- sive patients in zewditu memorial hospital, addis ababa.
CONCLUSION: The pattern of antihypertensive drug therapy in our patients was consistent with the current treatment guidelines. However, the majority of diabetic-hypertensive patients did not reach target blood pressure. PMID: 27476227 [PubMed - in process]
Source: Ethiopian Medical Journal - August 3, 2016 Category: African Health Tags: Ethiop Med J Source Type: research

Acute aortic occlusion in a patient without risk factors
A 94-year-old female with a history of ischemic stroke, mild right hemiparesis, vascular dementia, breast cancer with right mastectomy, colon cancer resulting in colectomy, hyperlipidemia, and hypertension presented to the emergency department (ED) with bilateral leg pain. Patient had no smoking history, and her medications included Donepezil, Aspirin, Citalopram, Losartan, and Pantoprazole.
Source: The American Journal of Emergency Medicine - March 28, 2018 Category: Emergency Medicine Authors: Trina Stoneham, Erin L. Simon Source Type: research

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia associated hypertension
This article is protected by copyright. All rights reserved
Source: Biotechnology and Applied Biochemistry - July 16, 2019 Category: Biochemistry Authors: Yogendra Singh, Vijaya Paul Samuel, Sunita Dahiya, Gaurav Gupta, Ritu Gillhotra, Anurag Mishra, Mahaveer Singh, Nagaraja SreeHarsha, Shiva Kumar Gubbiyappa, Murtaza M. Tambuwala, Dinesh Kumar Chellappan, Kamal Dua Tags: Review Article Source Type: research