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Condition: Epilepsy

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Total 2623 results found since Jan 2013.

Pediatric arterial ischemic stroke: Epidemiology, risk factors, and management.
Abstract Pediatric arterial ischemic stroke (AIS) is an uncommon but important cause of neurologic morbidity in neonates and children, with consequences including hemiparesis, intellectual disabilities, and epilepsy. The causes of pediatric AIS are unique to those typically associated with stroke in adults. Familiarity with the risk factors for AIS in children will help with efficient diagnosis, which is unfortunately frequently delayed. Here we review the epidemiology and risk factors for AIS in neonates and children. We also outline consensus-based practices in the evaluation and management of pediatric AIS. Fin...
Source: Blood Cells, Molecules and Diseases - March 7, 2017 Category: Hematology Authors: Felling RJ, Sun LR, Maxwell EC, Goldenberg N, Bernard T Tags: Blood Cells Mol Dis Source Type: research

Epileptic manifestations in stroke patients treated with intravenous alteplase
ConclusionsIntravenous alteplase is not associated with an increased risk of clinical or electroencephalographic epileptic phenomena.
Source: European Journal of Neurology - April 18, 2017 Category: Neurology Authors: C. Bentes, H. Martins, A. R. Peralta, C. Morgado, C. Casimiro, A. C. Franco, A. C. Fonseca, R. Geraldes, P. Canh ão, T. Pinho e Melo, T. Paiva, J. M. Ferro Tags: Original Article Source Type: research

The relationship between polypharmacy and recovery of activities of daily living among convalescent stroke patients: A propensity score-matched analysis
Conclusions These findings suggested that polypharmacy negatively affects stroke rehabilitation outcomes. Thus, pharmacists should make attempts to respond to individual patient outcomes to optimize prescriptions, which may minimize the brunt of polypharmacy on patient outcomes.
Source: European Geriatric Medicine - May 9, 2017 Category: Geriatrics Source Type: research

Epileptic seizures and epilepsy after a stroke : Incidence, prevention and treatment.
Abstract Following stroke, 3-6% of patients develop acute symptomatic seizures within the first 7 days. The rate is higher after cerebral haemorrhage compared to ischaemia. In 10-12% of patients, after more than 7 days unprovoked seizures occur. Due to these low incidence rates, primary prophylaxis with antiepileptic drugs is generally not necessary. Following one acute symptomatic seizure, recurrence risk within the first 7 days post-stroke is 10-20%, generally arguing against secondary prophylaxis with an antiepileptic drug. In clinical practice however, antiepileptic drug treatment in this constellation is o...
Source: Der Nervenarzt - June 14, 2017 Category: Neurology Authors: Benninger F, Holtkamp M Tags: Nervenarzt Source Type: research

DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies
AbstractDeath-associated protein kinase 1 (DAPK1), a Ca2+/calmodulin (CaM)-dependent serine/threonine protein kinase, plays important roles in diverse apoptosis pathways not only in tumor suppression but also in neuronal cell death. The requirement of DAPK1 catalytic activity for its proposed cell functions and the elevation of catalytic activity of DAPK1 in injured neurons in models of neurological diseases, such as ischemia and epilepsy, validate that DAPK1 can be taken as a potential therapeutic target in these diseases. Recent studies show that DAPK1-NR2B, DAPK1-DANGER, DAPK1-p53, and DAPK1-Tau are currently known path...
Source: Molecular Neurobiology - July 13, 2017 Category: Neurology Source Type: research

Wearable sensors for clinical applications in epilepsy, Parkinson ’s disease, and stroke: a mixed-methods systematic review
ConclusionsWearables may provide information of clinical features of interest in epilepsy, PD and stroke, but knowledge regarding the clinical utility for supporting clinical decision making remains to be established.
Source: Journal of Neurology - February 9, 2018 Category: Neurology Source Type: research

mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.
Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D Abstract Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke‑induced seizures, which may be associated with the regulation of energy metabolism of the brain. Mammalian target of rapamycin (mTOR) signaling and solute carrier family 2, facilitated glucose transporter member (GLUT)‑1 are critical for energy metabolism. Furthermore, mTOR overactivation and GLUT‑1 deficiency...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The Association Between Atrial Fibrillation and Poststroke Seizures is Influenced by Ethnicity and Environmental Factors
This study assessed whether ethnicity affects the association between AF and poststroke seizure (PSS) development. We hypothesized that Royal Melbourne Hospital ([RMH] Melbourne) patients will have significantly higher incidence of AF-related PSS than in the Jinling Hospital (Nanjing) population.
Source: Journal of Stroke and Cerebrovascular Diseases - July 21, 2018 Category: Neurology Authors: Jillian Naylor, Leonid Churilov, Benjamin Johnstone, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Arthur Thevathasan, Ziyuan Chen, Xinfeng Liu, Patrick Kwan, Bruce C.V. Campbell Source Type: research

Epilepsy after stroke: Definitions, problems and a practical approach for clinicians.
Authors: Quirins M, Dussaule C, Denier C, Masnou P Abstract Stroke, whether ischemic or hemorrhagic, is the main etiology of epilepsy in the elderly. However, incidences and outcomes differ according to stroke subtype and delay of onset following the stroke. While the medical literature is extensive, it is not always consistent, and many questions still remain regarding risk factors and management of vascular epilepsy. Thus, the present report here is an overview of the clinical aspects of vascular epilepsy using a practical approach that integrates data from meta-analyses and the more recently published expert rec...
Source: Revue Neurologique - November 14, 2018 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Stroke risk and outcomes in epilepsy patients: Two retrospective cohort studies based on National Health Insurance in Taiwan
The risk of stroke in epileptic patients and the impact of epilepsy history on stroke patients ’ outcome have not been studied completely. Our purpose is to evaluate whether patients with epilepsy have increased risk of stroke or post-stroke mortality.
Source: Atherosclerosis - November 22, 2018 Category: Cardiology Authors: Sanford P.C. Hsu, Chun-Chieh Yeh, Yi-Chun Chou, Chun-Chuan Shih, Chaur-Jong Hu, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao Source Type: research

Mitochondrial metabolic stroke: Phenotype and genetics of stroke-like episodes
Stroke-like episodes (SLEs) are the hallmark of mitochondrial encephalopathy with lactic acidosis and stroke-like episode (MELAS) syndrome but rarely occur also in other specific or nonspecific mitochondrial disorders. Pathophysiologically, SLLs are most likely due to a regional disruption of the blood-brain barrier triggered by the underlying metabolic defect, epileptic activity, drugs, or other factors. SLEs manifest clinically with a plethora of cerebral manifestations, which not only include features typically seen in ischemic stroke, but also headache, epilepsy, ataxia, visual impairment, vomiting, and psychiatric abnormalities.
Source: Journal of the Neurological Sciences - March 22, 2019 Category: Neurology Authors: Josef Finsterer Tags: Review Article Source Type: research

Long-term epilepsy after early post-stroke status epilepticus
ConclusionsNIHSS score>4 at the stroke presentation and PSSE duration>16 hours may predict of PSE in patients with early-onset PSSE. Recurrence may develop earlier in PSSE patients with longer duration of the episode.
Source: Seizure - May 2, 2019 Category: Neurology Source Type: research

Poststroke seizures as stroke mimics: Clinical assessment and management
This article is part of the Special Issue “Seizures & Stroke”.
Source: Epilepsy and Behavior - July 13, 2019 Category: Neurology Source Type: research

Efficacy of Statin Therapy in Post-Stroke Seizure Prophylaxis: Clues from an Observational Study of Routine Secondary Prevention Treatment
ConclusionsStatin treatment, especially with intensive-dose statins, can reduce the risk of PSS. In addition, the risk of developing PSE appears to be significantly lower for prolonged statin treatment. However, due to the observational nature of this study, more investigations are warranted to confirm its findings.
Source: Seizure - July 25, 2019 Category: Neurology Source Type: research

Statin effects on post-stroke epilepsy and mortality - Taiwan population-based study.
Conclusion: Statins have a modest but non-significant effect in preventing post-apoplectic epilepsy in Taiwan. Statins decrease post-stroke mortality only in men. Further studies are needed to depict their exact roles in these issues. PMID: 32122287 [PubMed - as supplied by publisher]
Source: Neurological Research - March 4, 2020 Category: Neurology Tags: Neurol Res Source Type: research