Filtered By:
Condition: Diabetes
Nutrition: Antidoxidants

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 112 results found since Jan 2013.

Icosapent Ethyl: drug profile and evidence of reduced residual cardiovascular risk in patients with statin-managed LDL-C cholesterol.
Authors: Bazarbashi N, Miller M Abstract INTRODUCTION: Icosapent Ethyl (IPE) is a highly purified (>96%) form of eicosapentanoic acid, a marine-derived omega-3 fatty acid known to reduce serum triglyceride levels. Experimental and human studies also support anti-atherosclerotic properties of IPE including antioxidant, anti-inflammatory, endothelial and plaque stabilizing effects. In the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT)l),the addition of 4 grams IPE daily resulted in a 25% reduction in cardiovascular events beyond statins and other standard of care therapies. ...
Source: Expert Review of Cardiovascular Therapy - April 2, 2020 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Therapeutic potential of phosphodiesterase inhibitors for endothelial dysfunction-related diseases.
Abstract Cardiovascular diseases (CVD) are considered a major health problem worldwide, being the main cause of mortality in developing and developed countries. Endothelial dysfunction, characterized by a decline in nitric oxide production and/or bioavailability, increased oxidative stress, decreased prostacyclin levels, and a reduction of endothelium-derived hyperpolarizing factor is considered an important prognostic indicator of various CVD. Changes in cyclic nucleotides production and/ or signalling, such as guanosine 3', 5'-monophosphate (cGMP) and adenosine 3', 5'-monophosphate (cAMP), also accompany many va...
Source: Current Pharmaceutical Design - April 2, 2020 Category: Drugs & Pharmacology Authors: Blanco-Rivero J, E Xavier F Tags: Curr Pharm Des Source Type: research

Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE).
CONCLUSION: Since there was no statistical significance between the probucol and control groups despite a marked reduction of HDL-C, further studies on the clinical outcomes of probucol on top of conventional therapy may be necessary in the future (UMIN000003307). PMID: 32336695 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - April 28, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Effects of Mulberry on the Central Nervous System: A Literature Review.
CONCLUSION: Mulberry species proved beneficial to many neurological functions in animal models. The active ingredients of each species, especially M. alba, should be deeper studied for screening potentially candidates for future treatments. PMID: 32379591 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - May 5, 2020 Category: Drugs & Pharmacology Authors: Tam DNH, Nam NH, Elhady MT, Tran L, Hassan OG, Sadik M, Tien PTM, Elshafei GA, Huy NT Tags: Curr Neuropharmacol Source Type: research

Vitamin C: historical perspectives and heart failure
AbstractVitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results....
Source: Heart Failure Reviews - October 8, 2020 Category: Cardiology Source Type: research

Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury
AbstractErgothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals, including humans, but is avidly taken up from the diet, especially from mushrooms. In the current study, we elucidated the effect of ET on the hCMEC/D3 human brain endothelial cell line. Endothelial cells are exposed to high levels of the cholesterol oxidation product, 7-ketocholesterol (7KC), in patients with cardiovascular disease and diabetes, and this process is thought to mediate pathological inflammation. 7KC induces a dose-dependent loss of cell viability and ...
Source: NeuroMolecular Medicine - October 16, 2020 Category: Neurology Source Type: research

A cross-sectional study of blood selenium concentration and cognitive function in elderly Americans: National Health and Nutrition Examination Survey 2011-2014.
Conclusions: Higher blood selenium is associated with higher cognitive scores in elderly Americans. PMID: 33050724 [PubMed - as supplied by publisher]
Source: Annals of Human Biology - October 21, 2020 Category: Biology Tags: Ann Hum Biol Source Type: research

A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications.
Abstract Modern lifestyle, changing eating habits and reduced physical work have been known to culminate into making diabetes a global pandemic. Hyperglycemia during the course of diabetes is an important causative factor for the development of both microvascular (retinopathy, nephropathy and neuropathy) and macrovascular (coronary artery disease, stroke and peripheral artery disease) complications. In this article, we summarize several mechanisms accountable for the development of both microvascular and macrovascular complications of diabetes. Several metabolic and cellular events are linked to the augmentation o...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Babel RA, Dandekar MP Tags: Curr Diabetes Rev Source Type: research

Serum Pro-oxidant-Antioxidant Balance in subjects with Type 2 Diabetes Mellitus.
CONCLUSION: Increased pro-oxidant levels may be a major complication of T2DM in our study subjects and PAB could be an indicator of higher oxidative stress in T2DM patients from northeastern Iran. PMID: 33155893 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - November 3, 2020 Category: Chemistry Authors: Ahmadnezhad M, Ghazizadeh H, Bijari M, Oladi MR, Esmaily H, Hoseini SJ, Barati E, Silakhori S, Moham-Madi-Bajgiran M, Davari H, Parizadeh MR, Mokhber N, Sharifan P, Aref-Hosseini SR, Ferns GA, Moohebati M, Ghayour-Mobarhan M Tags: Comb Chem High Throughput Screen Source Type: research

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective
Diabetes has reached worldwide epidemic proportions, and threatens to be a significant economic burden to both patients and healthcare systems, and an important driver of cardiovascular mortality and morbidity. Improvement in lifestyle interventions (which includes increase in physical activity via exercise) can reduce diabetes and cardiovascular disease mortality and morbidity. Encouraging a population to increase physical activity and exercise is not a simple feat particularly in individuals with co-morbidities (obesity, heart disease, stroke, peripheral vascular disease, and those with cognitive and physical limitations...
Source: Frontiers in Physiology - February 23, 2021 Category: Physiology Source Type: research

Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach
Cardiovascular complications are the foremost concern in patients undergoing anticancer therapy. There is an unmet need to address the problems arising from the drug-induced toxicity for the long-term benefit of the patients undergoing chemotherapy. Alternative medicines are gaining their prosperity in addressing the various drug-induced organ toxicity. Dillenia pentagyna Roxb (DP) is an ethnomedicinal plant rich in flavonoids and phenolic contents. In India & Nepal, DP is a common ingredient of traditional medicines used to treat multiple ailments like inflammation, cancer, and diabetes. However, its protective role a...
Source: Frontiers in Pharmacology - May 17, 2021 Category: Drugs & Pharmacology Source Type: research

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway
Aging (Albany NY). 2021 Jun 11;13. doi: 10.18632/aging.203137. Online ahead of print.ABSTRACTDiabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelli...
Source: Aging - June 12, 2021 Category: Biomedical Science Authors: Lian Liu Quan Cao Wenwei Gao Bingyu Li Zhongyuan Xia Bo Zhao Source Type: research

Association between serum Vitamin E concentrations and the presence of Metabolic Syndrome: A population-based cohort study
Conclusions. There is a significant inverse association between indices of Vit E status and the presence of MetS. Moreover, a significantly lower Vit E/ (TC+TG) was observed along with individuals with increasing numbers of components of the MetS.PMID:34212939 | DOI:10.23750/abm.v92i3.9173
Source: Acta Bio-Medica : Atenei Parmensis - July 2, 2021 Category: General Medicine Authors: Maral Barzegar-Amini Fateme Khorramruz Hamideh Ghazizadeh Reza Sahebi Maryam Mohammadi-Bajgyran Hossein Mohaddes Ardabili Maryam Tayefi Susan Darroudi Mohsen Moohebati Alireza Heidari-Bakavoli Akram Mohammadi Hamid Reza Sadeghnia Gordon A Ferns Seyed Java Source Type: research