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Condition: Huntington's Disease

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Total 289 results found since Jan 2013.

Creatine Revealed Anticonvulsant Properties on Chemically and Electrically Induced Seizures in Mice
In conclusion, creatine exerts anticonvulsant effects in three seizure models; therefore it may act as a potential drug to help patients with convulsions. However, further investigations should be done to clarify these results more.
Source: Iranian Journal of Pharmaceutical Research - October 31, 2016 Category: Drugs & Pharmacology Source Type: research

Brain Cells Of 'Villainous Character' Might Explain Diseases Like Parkinson's
This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.  -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - January 25, 2017 Category: Consumer Health News Source Type: news

High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation.
Abstract Neuroinflammation is a pathophysiological process present in a number of neurodegenerative disorders, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, traumatic brain injury including chronic traumatic encephalopathy and other age-related CNS disorders. Although there is still much debate about the initial trigger for some of these neurodegenerative disorders, during the progression of disease, broad range anti-inflammatory drugs including cytokine suppressive anti-inflammatory drugs (CSAIDs) might be promising therapeutic options to limit neuroinflammation and improve the c...
Source: Archives of Toxicology - February 14, 2017 Category: Toxicology Authors: Ullah F, Liang A, Rangel A, Gyengesi E, Niedermayer G, Münch G Tags: Arch Toxicol Source Type: research

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations
Activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and connectivity, and disruption of excitation–transcription coupling caused by CREB (cyclic adenosine monophosphate–responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone deacetylases. Interdependency within the triad fuels an accelerating disease progression that culminates in failure of mitochondrial energy production and cell loss. Bot...
Source: The Journal of Experimental Medicine - March 5, 2017 Category: Internal Medicine Authors: Bading, H. Tags: Neuroscience Review Source Type: research

Hyperglycemic chorea/hemiballism ascertained at a large medical center over 15 years: Frequency & characteristics (P2.019)
Conclusions:Hyperglycemia is common, but chorea triggered by hyperglycemia appears to be rare, with only seven cases identified at Mayo-Rochester during 15 years of surveillance. It tended to spare younger people and was primarily seen in later life (median age, 80). In the majority (4/7), it occurred in new-onset diabetes. It may be mistaken for a stroke, given the unilateral presentation (6/7). Although MRI putamen T1-hyperintensity is typical, this was absent in the majority (4/7). This syndrome responds to dopamine blocking or depleting medications.Disclosure: Dr. Ryan has nothing to disclose. Dr. Ahlskog has nothing t...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ryan, C., Ahlskog, J., Savica, R. Tags: Movement Disorders: Huntington ' s Disease, Chorea & amp;amp; Tardive Dyskinesia Source Type: research

A novel CABC1/ADCK3 mutation in Adult-onset cerebellar ataxia (P6.021)
Conclusions:This is the first report of a duplication mutation on ADCK3/CABC1 in a patient with adult-onset progressive ataxia, chronic motor tics and familial seizures. Further studies are needed to elucidate whether the gain of function or a duplication-induced loss of function play a role in the pathophysiology of this condition.Disclosure: Dr. Malgireddy has nothing to disclose. Dr. Thompson has nothing to disclose. Dr. Torres-Russotto has received pesonal compensation for activities with Abbvie, Allergan, the American Parkinson Disease Foundation (APDA), Lundbeck, Teva, Huntington Disease Society of America (HDSA), Pa...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Malgireddy, K., Thompson, R., Torres-Russotto, D. Tags: Movement Disorders: Tics, Tremor & amp;amp; Ataxia II Source Type: research

Striatal-enriched tyrosine protein phosphatase (STEP) in the mechanisms of depressive disorders.
Abstract Striatal-enriched tyrosine protein phosphatase (STEP) is expressed mainly in the brain. Its dysregulation is associated with Alzheimer's and Huntington's diseases, schizophrenia, fragile X syndrome, drug abuse and stroke/ischemia. However, an association between STEP and depressive disorders is still obscure. The review discusses the theoretical foundations and experimental facts concerning possible relationship between STEP dysregulation and depression risk. STEP dephosphorylates and inactivates several key neuronal signaling proteins such as extracellular signal-regulating kinase 1 and 2 (ERK1/2), stres...
Source: Current Protein and Peptide Science - July 10, 2017 Category: Biochemistry Authors: Kulikova E, Kulikov A Tags: Curr Protein Pept Sci Source Type: research

Rare Neurodegenerative Diseases: Clinical and Genetic Update.
Authors: Matilla-Dueñas A, Corral-Juan M, Rodríguez-Palmero Seuma A, Vilas D, Ispierto L, Morais S, Sequeiros J, Alonso I, Volpini V, Serrano-Munuera C, Pintos-Morell G, Álvarez R, Sánchez I Abstract More than 600 human disorders afflict the nervous system. Of these, neurodegenerative diseases are usually characterised by onset in late adulthood, progressive clinical course, and neuronal loss with regional specificity in the central nervous system. They include Alzheimer's disease and other less frequent dementias, brain cancer, degenerative nerve diseases, encephalitis, epilepsy, genetic brain disorders, head ...
Source: Advances in Experimental Medicine and Biology - December 9, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

The challenges of describing rehabilitation services: A discussion paper.
Authors: Røe C, Kirkevold M, Andelic N, Soberg HL, Sveen U, Bautz-Holter E, Jahnsen R, van Walsem MR, Bragstad LK, Hjelle EG, Klevberg G, Oretorp P, Habberstad A, Hagfors J, Væhle R, Engen G, Gutenbrunner C Abstract To apply the Classification of Service Organization in Rehabilitation (ICSO-R) classification of services to different target groups, include the user perspective, identify missing categories, and propose standardized descriptors for the categories from a Norwegian perspective. Expert-based consensus conferences with user involvement. Health professionals, stakeholders and users. Participants were div...
Source: Journal of Rehabilitation Medicine - December 22, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities".
Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affe...
Source: Current Neuropharmacology - January 10, 2018 Category: Drugs & Pharmacology Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Tags: Curr Neuropharmacol Source Type: research

REST, a master transcriptional regulator in neurodegenerative disease.
Abstract The restrictive element-1 silencing transcription factor)/NRSF (neuron-restrictive silencing factor (NRSF) is a transcriptional repressor which acts via epigenetic remodeling to silence target genes. Emerging evidence indicates that REST is a master transcriptional regulator of neuron-specific genes not only in neurogenesis and neuronal differentiation, but also in differentiated neurons during the critical period in postnatal brain development, where it plays a role in fine-tuning of genes involved in synaptic plasticity, and in normal aging, where it promotes neuroprotection by repressing genes involved...
Source: Current Opinion in Neurobiology - January 16, 2018 Category: Neurology Authors: Hwang JY, Zukin RS Tags: Curr Opin Neurobiol Source Type: research

Inflammation in CNS Neurodegenerative Diseases.
This article is protected by copyright. All rights reserved. PMID: 29513402 [PubMed - as supplied by publisher]
Source: Immunology - March 7, 2018 Category: Allergy & Immunology Authors: Stephenson J, Nutma E, van der Valk P, Amor S Tags: Immunology Source Type: research

The role of inflammation in neurological disorders.
Abstract Traditionally neurological diseases have been classified, on the basis of their pathogenesis, into vascular, degenerative, inflammatory and traumatic diseases. Examples of the main inflammatory neurological diseases include multiple sclerosis, which is characterized by an immune-mediated immune response against myelin proteins, and meningoencephalitis, where the inflammatory response is triggered by infectious agents. However, recent evidence suggests a potential role of inflammatory mechanisms also in neurological conditions not usually categorized as inflammatory, such as Alzheimer's disease, Parkinson'...
Source: Current Pharmaceutical Design - March 27, 2018 Category: Drugs & Pharmacology Authors: Degan D, Ornello R, Tiseo C, Carolei A, Sacco S, Pistoia F Tags: Curr Pharm Des Source Type: research

Insulinoma Masquerading as Transient Neurocognitive Impairment ✰, ✰✰, ✰✰✰
A 55-year-old man presented with six months of increasingly frequent episodes of confusion and abnormal behavior (Video 1). Neurologic examination and diagnostic workup were unremarkable. He was evaluated for stroke, Huntington's disease, conversion disorder, and other neuropsychiatric conditions without a satisfactory diagnosis. Months later, he suffered another episode and was found to have a glucose of 33 mg/dL. This improved with glucose administration, but rapidly dropped to 30 mg/dL. A 72-hour fast, which revealed a low serum glucose and elevated insulin, pro-insulin, and c-peptide levels, strongly suggested the diagnosis of insulinoma.
Source: The American Journal of Medicine - May 10, 2018 Category: General Medicine Authors: Daniel Varela, Amy Yu, David Saxon Tags: Clinical Communication to the Editor Source Type: research