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"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities".

"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities". Curr Neuropharmacol. 2018 Jan 10;: Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affect all ages. Owing to an energy and/or oxygen supply imbalance, different signaling mechanisms including MAPK/PI3K-Akt signaling pathways, glutamatergic synapse formation, and/or translocation of phosphatidylserine, might activate some central executing mechanism common to all these pathologies and also related to oxidative stress. Hypoxia inducible factor 1- (HIF-1) plays a twofold role through gene activation, in the sense that this factor has to "choose" whether to protect or to kill the affected cells. Most of the afore-mentioned processes follow a protracted course and are accompanie...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

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CONCLUSION: Language recovery after left hemispheric ischemic stroke is likely driven by the previously involved in language and attention left hemispheric networks. PMID: 29782329 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
Authors: Ogourtsova T, Archambault PS, Lamontagne A Abstract BACKGROUND: Unilateral spatial neglect (USN), a highly prevalent and disabling post-stroke deficit, has been shown to affect the recovery of locomotion. However, our current understanding of USN role in goal-directed locomotion control, and this, in different cognitive/perceptual conditions tapping into daily life demands, is limited. OBJECTIVES: To examine goal-directed locomotion abilities in individuals with and without post-stroke USN vs. healthy controls. METHODS: Participants (n = 45, n = 15 per group) performed goal-directed locomot...
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
CONCLUSION: The results suggest that WMH may be an important factor to consider in stroke-related upper extremity motor impairment. Nonetheless, the basis of the largest part of the post-stroke motor deficit remains unaccounted for by structural CNS factors. This component may be behavioral or learned, involving learned nonuse. PMID: 29782327 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
WALKING to work saves lives by cutting the chance of death by stroke and heart disease, a study claims.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Hooykaas PJJ, van Heusden GPH, Niu X, Reza Roushan M, Soltani J, Zhang X, van der Zaal BJ Abstract Two decades ago, it was discovered that the well-known plant vector Agrobacterium tumefaciens can also transform yeasts and fungi when these microorganisms are co-cultivated on a solid substrate in the presence of a phenolic inducer such as acetosyringone. It is important that the medium has a low pH (5-6) and that the temperature is kept at room temperature (20-25 °C) during co-cultivation. Nowadays, Agrobacterium-mediated transformation (AMT) is the method of choice for the transformation of many f...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Laura McCulloch, Alessio Alfieri, Barry W. McColl
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Conclusion: Achieved performances highlight the feasibility of seizure forecasting in canine epilepsy. Significance: The ability to improve seizure forecasting provides promise for the development of EEG-triggered closed-loop seizure intervention systems for ambulatory implantation in patients with refractory epilepsy.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
HIGH blood pressure happens when the force blood is pumped around your body and the resistance to blood flow is higher than recommended levels. It is important to lower your blood pressure if it is too high, as it increases your risk of developing heart disease, kidney disease and strokes among others. Drinking this £2 juice could lower your blood pressure.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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