"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities".

"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities". Curr Neuropharmacol. 2018 Jan 10;: Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affect all ages. Owing to an energy and/or oxygen supply imbalance, different signaling mechanisms including MAPK/PI3K-Akt signaling pathways, glutamatergic synapse formation, and/or translocation of phosphatidylserine, might activate some central executing mechanism common to all these pathologies and also related to oxidative stress. Hypoxia inducible factor 1- (HIF-1) plays a twofold role through gene activation, in the sense that this factor has to "choose" whether to protect or to kill the affected cells. Most of the afore-mentioned processes follow a protracted course and are accompanie...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

Related Links:

A growing number of studies suggest that getting a handle on a few key risk factors can bring type 2 diabetes under control. Lowering blood sugar, for instance, reduces the risk of additional health problems, such as heart disease and stroke related to the disease. But most of these studies have focused on studying one risk factor — like blood sugar, cholesterol or blood pressure — at a time. In a new study published in the New England Journal of Medicine, researchers analyzed what happens to death rates and other health problems when people control up to five known risk factors for type 2 diabetes. The study ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime medicine Source Type: news
(MedPage Today) -- Dopamine loss tied to retinal thinning; may be early disease biomarker
Source: MedPage Today Neurology - Category: Neurology Source Type: news
Abstract Recently we have found that cytokine IL-2 and innate immunity protein Tag7 activate cytotoxic lymphocytes that kill HLA-negative tumor cells, inducing both apoptosis and necroptosis. Here we decrypt the processes, taking part in necroptosis execution after FasL-Fas interaction. Necroptosis begins with RIPK1 activation and necrosome formation. Subsequent activation of MLKL results in the increase of Ca2+ level in the cell and activation of Ca2+-dependent enzymes causing lysosomal membrane permeabilization and the release of cathepsins to the cytosol. STAT3 translocation to the mitochondria and binding to a...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
Authors: An L, Adeli E, Liu M, Zhang J, Shen D Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs a patient's memory and other important mental functions. In this paper, we leverage the mutually informative and complementary features from both structural magnetic resonance imaging (MRI) and single nucleotide polymorphism (SNP) for improving the diagnosis. Due to the feature redundancy and sample outliers, direct use of all training data may lead to suboptimal performance in classification. In addition, as redundant features are involved, the most discriminative feature subset ...
Source: MICCAI International Conference on Medical Image Computing and Computer-Assisted Intervention - Category: Radiology Tags: Med Image Comput Comput Assist Interv Source Type: research
STATE HOUSE, BOSTON, August 15, 2018 (State House News Service) — A new state law aims to change the way Alzheimer’s Disease diagnoses and treatment are handled in Massachusetts in hopes of addressing what one advocate said is currently the “single largest unaddressed public health threat.” The law, which Gov. Charlie Baker signed on Aug. 9 and marked with a ceremonial signing on Wednesday, requires the creation of an “integrated state plan to address and assist in the treatment of Alzheimer’s disease,” establishes an advisory council on research and treatment, and calls upon docto...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Alzheimer's Disease Local TV Source Type: news
Conclusion: This study contributes to the sparse literature in this field by demonstrating the high efficacy and low morbidity of MRgLITT as a minimally invasive method of ablation of epileptic foci in the pediatric population of medically refractory lesional epilepsy.Pediatr Neurosurg
Source: Pediatric Neurosurgery - Category: Neurosurgery Source Type: research
Publication date: September 2018Source: Biomedical Signal Processing and Control, Volume 46Author(s): Savitha S. Upadhya, A.N. Cheeran, J.H. NirmalAbstractIn this paper, MFCC and PLP voice features extracted using Single Taper Smooth (STS) window and Thomson Multitaper (TMT) windowing technique together with a neural network classifier is used in the classification of Healthy people from early stage Parkinson diseased patients and a performance comparison of the two techniques is reported. Parkinson disease in their early stages, not only affects the muscular movements of the human body but also influences the articulatory...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN01205A, PaperMaria Paraskevaidi, Camilo Morais, Daniel L. D. Freitas, Kassio Michell Gomes de Lima, David M. A Mann, David Allsop, Pierre L Martin-Hirsch, Francis L Martin Alzheimer ’s disease (AD) is currently under-diagnosed and is predicted to affect a great number of people in the future, due to the unrestrained aging of the population. An accurate diagnosis... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
The expert who once coined the rule 'Time is brain!' uses a model to argue that there is also a need to consider the circulation pattern in the brain.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Stroke Source Type: news
Authors: Wegehaupt FJ, Schleich J, Hamza B, Wiedemeier D, Attin T Abstract We compared the prevention of erosive and erosive/abrasive enamel loss by a medical minerals gel system (R.O.C.S.) to that by an anti-erosive toothpaste. Seventy-two bovine enamel samples were randomly allocated to six groups (E1–E3 and EA1–EA3; n=12). Per day, samples were eroded (2 min) 9 times using HCl (pH 2.6). Between erosive challenges and over night samples were stored in artificial saliva. Per day, samples were stored (100 s; groups E1–E3) or additionally brushed (20 brushing strokes; groups EA1–EA3) in/with ...
Source: Schweizer Monatsschrift fur Zahnmedizin - Category: Dentistry Tags: Swiss Dent J Source Type: research
More News: ALS | Alzheimer's | Brain | Drugs & Pharmacology | Epilepsy | Genetics | Huntington's Disease | Iron | Men | Multiple Sclerosis | Neurology | Parkinson's Disease | Stroke | Translocation