Rare Neurodegenerative Diseases: Clinical and Genetic Update.

Rare Neurodegenerative Diseases: Clinical and Genetic Update. Adv Exp Med Biol. 2017;1031:443-496 Authors: Matilla-Dueñas A, Corral-Juan M, Rodríguez-Palmero Seuma A, Vilas D, Ispierto L, Morais S, Sequeiros J, Alonso I, Volpini V, Serrano-Munuera C, Pintos-Morell G, Álvarez R, Sánchez I Abstract More than 600 human disorders afflict the nervous system. Of these, neurodegenerative diseases are usually characterised by onset in late adulthood, progressive clinical course, and neuronal loss with regional specificity in the central nervous system. They include Alzheimer's disease and other less frequent dementias, brain cancer, degenerative nerve diseases, encephalitis, epilepsy, genetic brain disorders, head and brain malformations, hydrocephalus, stroke, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS or Lou Gehrig's Disease), Huntington's disease, and Prion diseases, among others. Neurodegeneration usually affects, but is not limited to, the cerebral cortex, intracranial white matter, basal ganglia, thalamus, hypothalamus, brain stem, and cerebellum. Although the majority of neurodegenerative diseases are sporadic, Mendelian inheritance is well documented. Intriguingly, the clinical presentations and neuropathological findings in inherited neurodegenerative forms are often indistinguishable from those of sporadic cases, suggesting that converging genomic signatures and pathophysiologic mechanisms und...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Publication date: August–September 2018Source: Medicina Intensiva (English Edition), Volume 42, Issue 6Author(s): F.D. Martos-Benítez, A. Gutiérrez-Noyola, M. Badal, N.A. DietrichAbstractObjectivesTo determine the risk factors for severe acute respiratory failure requiring invasive mechanical ventilation (SARF-MV) and its effect upon clinical outcomes in critically ill cancer patients.DesignA retrospective cohort study was carried out.SettingA 12-bed oncological intensive care unit (ICU) from January 2014 to December 2015.PatientsA total of 878 consecutive cancer patients were included. Patients with an...
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
Publication date: August–September 2018Source: Medicina Intensiva (English Edition), Volume 42, Issue 6Author(s): A. Carmona-Bayonas, F. Gordo, C. Beato, J. Castaño Pérez, P. Jiménez-Fonseca, J. Virizuela Echaburu, J. Garnacho-MonteroAbstractCancer patients are a vulnerable group exposed to numerous and serious risks beyond cancer itself. In recent years, the prognosis of these individuals has improved substantially thanks to several advances such as immunotherapy, targeted molecular therapies, surgical techniques, or developments in support treatment. This coincides with the prolonged survival o...
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
SKIN cancer symptoms are triggered when skin cells start to divide uncontrollably. There are two main types of skin cancer, called melanoma and non-melanoma skin cancer. Watch out for this major warning sign of skin cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Emma Neagu, now 14, from Toronto, was diagnosed with a form of bone cancer known as osteosarcoma in 2016. The teen endured nine months of grueling chemotherapy.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Laurent M. Willems, Astrid Bertsche, Frank B ösebeck, Frauke Hornemann, Ilka Immisch, Karl M. Klein, Susanne Knake, Rhina Kunz, Gerhard Kurlemann, Lisa Langenbruch, Gabriel Möddel, Karen Müller-Schlüter, Felix von Podewils, Philipp S. Reif, Bernhard J. Steinhoff, Isabel Steinig, Felix Rosenow, Susanne Schubert-Bast, Adam Strzelczyk
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS In a Han Chinese population, EGFR gene polymorphisms, rs730437 and rs1468727 and haplotype A-C-C were shown to be possible protective factors for the development of AD. PMID: 30026459 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This article focused on the CML and epigenetic and clinical significance. An electronic search of peer-reviewed articles was systematically performed to obtain the relevant literature with the CINAHL, cancer, Google scholar, self-experience and PubMed databases. The keywords included leukemia, cancer, illness, epigenetic. The inclusion criteria for the reviews were that the documents were original quantitative research and published in English. Articles that were not directly relevant to the present objective were excluded. Current progress in molecular biology and bioinformatics offer novel promising experiments namely as...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Authors: Steckiewicz KP, Barcińska E, Woźniak M Abstract Nerve growth factor (NGF) is protein discovered by Rita Levi Montalcini in the 1950s. It plays a crucial role in the development of nervous system. NGF may be produced by a variety of cells even beyond nervous system. NGF modulate cell metabolism by binding to p75NTR and TrkA receptors. NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and cardiovascular diseases, which will be described in the article. PMID: 30030957 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
BOWEL cancer symptoms occur when cells start to divide uncontrollably in the large intestine. Signs and symptoms can be observed in the toilet bowl, or through how someone is feeling. Watch out for these warning signs of colon cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Obesity, Type 2 diabetes and metabolic syndrome, all of which have risen to epidemic levels in recent years, are linked to pancreatic cancer.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Pancreatic Cancer Smoking and Tobacco Pancreas Diabetes Source Type: news
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