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Let us Break the Heart Attack Related Myths in Women on the Eve of International Women ’s Day
Several myths surrounding heart diseases state that heart diseases attract only elder people and more men than women are prone to heart attacks. Contrary to the belief, cardiovascular cases are on rise in women than men and it is deadlier than all forms of cancers combined. Both physiological and psychological factors are causing heart diseases and it affects people of all ages with no bias. Women that have suffered from mental illness are more susceptible to attract heart risks like stroke. Mental ill health like schizophrenia, anxiety disorders and bipolar disorders are mostly treated with antidepressants, antipsychotics...
Source: Sciences Blog - March 9, 2018 Category: Science Authors: srinivas_s at omicsgroup.co.in (OMICS Publishing Group) Tags: OMICS Anxiety Disorders bipolar disorders cardiovascular cases heart attacks heart diseases psychological factors Source Type: blogs

Molecules, Vol. 23, Pages 719: Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3 β Inhibitors
Molecules, Vol. 23, Pages 719: Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors Molecules doi: 10.3390/molecules23040719 Authors: Daniela Hulcová Kateřina Breiterová Tomáš Siatka Kamila Klímová Lara Davani Marcela Šafratová Anna Hošťálková Angela De Simone Vincenza Andrisano Lucie Cahlíková Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism. It plays a key role in diverse physiological processes including metabolism, the cel...
Source: Molecules - March 21, 2018 Category: Chemistry Authors: Daniela Hulcov á Kate řina Breiterová Tom áš Siatka Kamila Kl ímová Lara Davani Marcela Šafratová Anna Ho šťálková Angela De Simone Vincenza Andrisano Lucie Cahl íková Tags: Article Source Type: research

TRPM2: a candidate therapeutic target for treating neurological diseases.
Abstract Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca2+)-permeable non-selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced TRPM2 activation provokes aberrant intracellular Ca2+ accumulation and cell death in a variety of cell types, including neurons. Aberrant TRPM2 function has been implicated in several neurological disorders including ischemia/stroke, Alzheimer's disease, neuropathic pain, Parkinson's disease and bipolar disorder. In addition to research identifying a role for TRPM2 in disease, progress has been made in the identification of physiolog...
Source: Acta Pharmacologica Sinica - April 19, 2018 Category: Drugs & Pharmacology Authors: Belrose JC, Jackson MF Tags: Acta Pharmacol Sin Source Type: research

Metallomics Applied to the  Study of Neurodegenerative and Mental Diseases.
Metallomics Applied to the Study of Neurodegenerative and Mental Diseases. Adv Exp Med Biol. 2018;1055:21-37 Authors: Sussulini A, Hauser-Davis RA Abstract Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiolo...
Source: Advances in Experimental Medicine and Biology - June 11, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature
Publication date: Available online 2 August 2018Source: International Review of NeurobiologyAuthor(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors ...
Source: International Review of Neurobiology - August 3, 2018 Category: Neuroscience Source Type: research

rTMS Effects in Patients with Co-Morbid Somatic Pain and Depressive Mood Disorders
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation treatment that involves the induction of electrical currents in a targeted region of the brain with the ability to impact various functional processes (Chervyakov  et al., 2015). rTMS has shown to provide clinical improvement among a variety of neurological and psychiatric disorders and has been FDA-approved for treatment resistant depression (TRD). rTMS continues to undergo trials for other treatment indications including post-traumatic stress disorder (PT SD), generalized anxiety disorder (GAD), bipolar depression, schizophrenia, stro...
Source: Journal of Affective Disorders - August 18, 2018 Category: Neurology Authors: Angela L. Phillips, Robert L. Burr, David L. Dunner Tags: Research paper Source Type: research

Chapter Seventeen - Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature
Publication date: 2018Source: International Review of Neurobiology, Volume 139Author(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors (placebo respo...
Source: International Review of Neurobiology - August 24, 2018 Category: Neuroscience Source Type: research

Midterm outcomes of mini-invasive surgical and hybrid ablation of atrial fibrillation.
CONCLUSIONS: . Combination of mini-invasive surgical and endocardial treatment (two-stage hybrid procedure) is a safe and effective method for the treatment of isolated (lone) AF. This procedure provided good midterm outcomes. PMID: 30214077 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 16, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity.
Conclusion: Heat stimulation by M-RF treatment induced upregulation of UCP1 and FGF21 expression in serum and/or WATs, which was correlated with reduced total body and WAT weight gain in DIO mice. PMID: 30275865 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - October 4, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3 β inhibition in intracerebral hemorrhage rats.
In this study, Male Sprague-Dawley rats, subjected to intrastriatal blood infusion, were treated with lithium chloride and underwent neurobehavioral test for equivalent injury severity and neurological functional deficits, Morris water maze test for cognitive impairment, high performance liquid chromatography analysis for excitotoxic index determination, immunohistochemistry analysis for neuronal apoptosis, and Western blot analysis for glycogen synthase kinase-3β activity. Our results showed lithium chloride inhibited glycogen synthase kinase-3β activation, which on one hand, suppressed downstream CRMP-2/NR2B, thus dimi...
Source: European Journal of Pharmacology - October 15, 2018 Category: Drugs & Pharmacology Authors: Liu Z, Li R, Jiang C, Zhao S, Li W, Tang X Tags: Eur J Pharmacol Source Type: research

Lithium intoxication presenting as altered consciousness and arrhythmia with cardiogenic shock: A case report
Rationale: Lithium has been used to treat bipolar disorder. Lithium has a narrow therapeutic index, with a therapeutic level between 0.6 and 1.5 mEq/L. The possible complications of lithium overdose include altered mental status, hand tremor, muscle weakness, nausea, vomiting, diarrhea, seizure, syncope, and arrhythmia. Lithium intoxication can be fatal and is difficult to diagnose in patients without a history of lithium intake. The occurrence of serious cardiac arrhythmias is rare in lithium intoxication. Patient concerns: An 81-year-old man was brought to the emergency department because of consciousness disturba...
Source: Medicine - November 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Impact of a prudent lifestyle on the clinical outcomes of older men with bipolar disorder.
CONCLUSION: The excess morbidity and mortality of older men with BD seems to be mediated by non-prudent lifestyle practices. If future studies can demonstrate that this association is causal, then lifestyle interventions will need to become an integral part of the management of older adults with BD. PMID: 30596455 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - December 31, 2018 Category: Geriatrics Authors: Almeida OP, Hankey GJ, Yeap BB, Flicker L Tags: Aging Ment Health Source Type: research

Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3 β inhibitors: A critical review.
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review. Eur J Med Chem. 2018 Dec 31;164:448-470 Authors: Xu M, Wang SL, Zhu L, Wu PY, Dai WB, Rakesh KP Abstract Glycogen Synthase Kinase-3 (GSK-3) is a constitutively dynamic, omnipresent serine/threonine protein kinase regularly called as a "multitasking kinase" due to its pliable function in diverse signaling pathways. It exists in two isoforms i.e., GSK-3α and GSK-3β. Inhibition of GSK-3 may be useful in curing various diseases such as Alzheimer's disease, type II diabetes, mood disorde...
Source: European Journal of Medicinal Chemistry - December 31, 2018 Category: Chemistry Authors: Xu M, Wang SL, Zhu L, Wu PY, Dai WB, Rakesh KP Tags: Eur J Med Chem Source Type: research

Atorvastatin in the treatment of lithium-induced nephrogenic diabetes insipidus: the protocol of a randomized controlled trial
Lithium is the gold-standard treatment for bipolar disorder, is highly effective in major depressive disorder, and is being investigated for therapeutic benefits in dementia, stroke, and even cancer. Approximately 350,000 Canadians use lithium and more could benefit. Despite this, clinicians are avoiding lithium, largely due to fear of renal toxicity, including irreversible chronic kidney disease (CKD). Nephrogenic Diabetes Insipidus (NDI) occurs in 20% of lithium users and independently predicts a 2-3 times increased risk of CKD.
Source: The American Journal of Geriatric Psychiatry - February 28, 2019 Category: Geriatrics Authors: Jocelyn Fotso Soh, Gabriela Torres-Platas, Serge Beaulieu, Outi Mantere, Robert Platt, Istvan Mucsi, Sybille Saury, Suzane Renaud, Andrea Levinson, Ana Andreazza, Benoit Mulsant, Daniel Mueller, Ayal Schaffer, Annemiek Dols, Nancy Low, Pablo Cervantes, Na Tags: Poster Number: EI - 48 Source Type: research

Metabolic Effects of Antipsychotic Medications
Patients diagnosed with severe mental illnesses, such as schizophrenia and bipolar affective disorder, and mood disorders are often prescribed second-generation, or atypical, antipsychotics (SGAs) to help manage their conditions. The use of these medications is associated with significant adverse metabolic effects, including weight gain, glycemic dysfunction, and dyslipidemia.1,2 Furthermore, patients diagnosed with severe mental illnesses have significantly increased cardiovascular mortality and morbidity and are 1.5-times to 3-times more likely to suffer from a myocardial infarction or stroke when prescribed SGAs.
Source: The Journal for Nurse Practitioners - April 14, 2019 Category: Nursing Authors: J. Casey Elkins Tags: Prescription Pad Source Type: research