Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature

Publication date: Available online 2 August 2018Source: International Review of NeurobiologyAuthor(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors (placebo responses). However, adverse events (AEs) may occur when using a placebo intervention, a phenomenon that is called nocebo. Like placebo, the nocebo effect is a cognitive and idiosyncratic phenomenon with specific biological bases, controlled by distinctive neurotransmitters within mapped brain areas most likely located within the network of the limbic system.Nocebo responses has been found to be very prevalent in various neurological conditions, in particular, in many brain disorders including headache, Parkinson's disease, Alzheimer's disease, depression, epilepsy, multiple sclerosis and motor neuron disease. Pooled AE rates in the placebo groups (nocebo AE rates) vary from 25% in the symptomatic treatment for multiple sclerosis RCTs to almost 80% in motor neuron disease RCTs. Pooled dropout rates because of AEs in the placebo groups (i.e., nocebo ...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research

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In this report, a 16-year-old boy presented with jaundice, nausea, vomiting and reduced urine output. He developed severe acute renal/hepatic damage due to abuse of gas products. Since toluene is the main toxic agent involved in glue sniffing which is metabolized to hippuric acid, the present case was treated with continuous hemodiafiltration, plasma exchange and conservative therapy to eliminate hippuric acid. The jaundice gradually disappeared, he had complete recovery of renal/hepatic functions in ten days. We aimed to increase the awareness among emergency physicians that ``glue sniffing` should be considered in the di...
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
Authors: Tofte A, Narang P, Lippmann S PMID: 30326187 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Conclusions: In general, the results from the reviewed studies suggest that BTA may be a promising treatment for MDD. However, these findings need to be interpreted with caution due to several limitations of the reviewed studies such as lack of a priori hypotheses, limited sample sizes, large gender bias, and significant difficulty in ensuring blinding. PMID: 30326186 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Publication date: Available online 17 October 2018Source: Social Science &MedicineAuthor(s): Claire Snell-Rood, Elizabeth Carpenter-SongAbstractPeople with mental illness face public scrutiny that provokes questions about their ability to cope, membership in society, and entitlement to state support. Less attention has been focused on how such scrutiny occurs at the community level, particularly when shared economic distress has generated a high burden of poor mental health. We employ theorizations of health-related deservingness to examine the local moral economies through which residents of an economically depressed ...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Source: BMJ - Category: General Medicine Source Type: research
You're reading 4 Bestselling Authors Share Their 4 Most Favorite Success Tips, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Bestselling authors; Jordan Peterson, Jen Sincero, Mark Divine and Brad Gilbert share their four favorite success tips. Here they are… Success Tip#1: Treat yourself like you treat your dog (Assuming you`re not some animal-abusing psycho” “People appear to love their dogs, cats, ferrets, and birds (and maybe even their lizards) more than themselves. How horrible is that? How much...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured motivation self improvement success writing tips #success #doyourbest Source Type: blogs
We present a case of hypertensive emergency complicated with acute spontaneous SDH..
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
CONCLUSION: Our results indicate that besides delivering high-quality acoustic care, practitioners should continuously check patients' requirements for psychosocial treatment due to a loss of quality of life. The development of a specific psychotherapeutic treatment for hearing-impaired clients requires additional research focused on protective and vulnerability factors which may influence the emergence of mental disorders in these patients. PMID: 30324556 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Conclusions: This study elucidated the sociodemographic and behavioral risk profile of a sample of TGD youth in the MHS. Military and non-military health care providers across a broad spectrum of specialties should be knowledgeable about the unique psychosocial and medical needs, requisite sensitivity, and available referral options in the care of TGD youth. Assumptions about one's gender identity, sexual orientation, gender expression, or behaviors cannot be made based on birth-assigned sex. Further research is needed to investigate the health and wellbeing of TGD military-affiliated youth over time and to determine quali...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
AbstractPurpose of ReviewAn understanding of the basics concepts of deep learning can be helpful in not only understanding the potential applications of this technique but also in critically reviewing literature in which neural networks are utilized for analysis and modeling.Recent FindingsThe term “deep learning” has been applied to a subset of machine learning that utilizes a “neural network” and is often used interchangeably with “artificial intelligence.” It has been increasingly utilized in healthcare for computational “learning”, especially for pattern recognition for d...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
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