Chapter Seventeen - Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature
Publication date: 2018Source: International Review of Neurobiology, Volume 139Author(s): Panagiotis Zis, Dimos-Dimitrios MitsikostasAbstractPlacebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about treatment (placebo effects), or confounding factors such as natural history, co-interventions, biases, among other co-factors (placebo responses). However, adverse events (AEs) may occur when using a placebo intervention, a phenomenon that is called nocebo. Like placebo, the nocebo effect is a cognitive and idiosyncratic phenomenon with specific biological bases, controlled by distinctive neurotransmitters within mapped brain areas most likely located within the network of the limbic system.Nocebo responses has been found to be very prevalent in various neurological conditions, in particular, in many brain disorders including headache, Parkinson's disease, Alzheimer's disease, depression, epilepsy, multiple sclerosis and motor neuron disease. Pooled AE rates in the placebo groups (nocebo AE rates) vary from 25% in the symptomatic treatment for multiple sclerosis RCTs to almost 80% in motor neuron disease RCTs. Pooled dropout rates because of AEs in the placebo groups (i.e., nocebo dropout rates)...
CONCLUSION: there were an expressive quantitative number of absences due to depression, in which it was observed, especially, that the absence time remained long. PMID: 32491123 [PubMed - in process]
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC01971B, CommunicationWenxiao Wu, Tingting Zheng, Yang Tian An enzyme-free amplification strategy based on two-photon fluorescent carbon dots for monitoring miR-9 in live neurons and brain tissues of Alzheimer ’s disease (AD) mice. Notably, using our developed probe, miR-9... The content of this RSS Feed (c) The Royal Society of Chemistry
In this study, we established a specific anti-human DGKη (hDGKη) mAb, DhMab-4 (mouse IgG2b, kappa). DhMab-4 strongly stained Purkinje cells of human cerebellum in immunohistochemistry analysis. For epitope mapping of DhMab-4, we produced deletion or point mutants of hDGKη and performed western blotting to determine the binding epitope of DhMab-4. DhMab-4 reacted with dN745 mutant but not with dN750 mutant, indicating that the N-terminus of the DhMab-4 epitope is located between amino acids 745 and 750. More detailed analysis using point mutants demonstrated that five mutants, that is, D747A, P748A, F749A, G750A...
CONCLUSION: depressive symptoms are associated with burden of comorbidities, greater number of disease complications, hemodialytic intercurrences and functional dependence. Physical exercise practice can be an effective care strategy. PMID: 32490957 [PubMed - in process]
CONCLUSION: Quality of life and social support were identified as protective factors for depressive symptoms while being at risk of malnutrition, living alone, reporting pain and being female are predictors. PMID: 32490955 [PubMed - in process]
Abstract OBJECTIVE: To measure and correlate the degree of psychological well-being, quality of life, and dispositional hope in family caregivers of schizophrenic people. METHODS: Descriptive cross-sectional study conducted with 117 relatives of schizophrenic people. We applied a questionnaire of sociodemographic variables was applied, and the instruments World Health Organization 5-Item Well-Being (WHO-5), World Health Organization Quality of Life Abbreviated (WHOQOL-Bref), and Dispositional Hope Scale. We used The Kruskal Wallis, Jonckheere-Terpstra, and Spearman correlation tests at the level α
SafetyLit note (June 2020): This publication uses the ISTIC as its DOI registry. Thus, in some nations, this DOI may not forward to the publisher website for obtaining full text. Objective To understand the epidemic characteristics and trends of suicid...
Publication date: Available online 3 June 2020Source: The Arts in PsychotherapyAuthor(s): Kevin Charras, Jean-Bernard Mabire, Nathalie Bouaziz, Peggy Deschamps, Bénédicte Froget, Adèle de Malherbe, Sara Rosa, Jean-Pierre Aquino
Publication date: Available online 3 June 2020Source: SeizureAuthor(s): Maria Teresa Faria, Ricardo Rego, Helena Rocha, Francisca Sá, Rui Farinha, Ana Oliveira, Pedro Barata, Dílio Alves, Jorge Pereira, Francisco Rocha-Gonçalves, Hernâni Gonçalves, Elisabete Martins
Publication date: Available online 3 June 2020Source: Brain StimulationAuthor(s): Bornali Kundu, Tyler S. Davis, Brian Philip, Elliot H. Smith, Amir Arain, Angela Peters, Blake Newman, Christopher R. Butson, John D. Rolston