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Condition: Diabetes Mellitus
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Total 59605 results found since Jan 2013.
Impact of tofogliflozin on hepatic outcomes: a systematic review
ConclusionOverall, an improvement in levels of hepatic parameters was observed in T2DM patients with concurrent liver disorders. However, a large number of clinical trials are needed to prove the efficacy of tofogliflozin on hepatic outcomes in patients with T2DM.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
In this study, we investigated the role of STIM1 in the proliferation and fibrosis in high glucose (HG)-induced HBZY-1 cells. We found that the expression of STIM1 was increased in renal tissues of diabetic rat and HBZY-1 cells stimulated by HG. Downregulation of STIM1-mediated SOCE suppressed hyperglycemic cell proliferation and fibrosis by activating autophagy. In addition, the inhibitory effect of downregulating STIM1 on cells was blocked by autophagy inhibitor Bafilomycin A1 (BafA1). Moreover, this experiment also showed that STIM1 regulated autophagy, cell proliferation and fibrosis via PI3K/AKT/mTOR signal pathway. T...
Source: Molecular and Cellular Biochemistry - September 22, 2023 Category: Biochemistry Authors: Xixi Zeng Anbang Sun Weiyi Cheng Xin Hou Min Zhu Yanhong Liao Source Type: research
A Systematic Review of Methodologies Used in Models of the Treatment of Diabetes Mellitus
ConclusionsModels developed in the past 12 years for health economic evaluations of diabetes treatments are of high-quality and make use of advanced methods. However, further developments are needed to improve the statistical modelling component of cost-effectiveness models and to provide better assessment of structural uncertainty.
Source: PharmacoEconomics - September 22, 2023 Category: Health Management Source Type: research
Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study
ConclusionThis study provides MR evidence supporting causal associations of many modifiable risk factors with kidney stones. Sedentary lifestyles, obesity, smoking, and T2DM are mediating factors in the causal relationship between educational attainment and kidney stones. Our results suggest more attention should be paid to these modifiable factors to prevent kidney stones.
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research
Insulin Therapy for the Management of Diabetes Mellitus: A Narrative Review of Innovative Treatment Strategies
AbstractThe discovery of insulin was presented to the international medical community on May 3, 1922. Since then, insulin has become one of the most effective pharmacological agents used to treat type 1 and type 2 diabetes mellitus. However, the initiation and intensification of insulin therapy is often delayed in people living with type 2 diabetes due to numerous challenges associated with daily subcutaneous administration. Reducing the frequency of injections, using insulin pens instead of syringes and vials, simplifying treatment regimens, or administering insulin through alternative routes may help improve adherence to...
Source: Diabetes Therapy - September 22, 2023 Category: Endocrinology Source Type: research
Mucormycosis: update on clinical presentation, diagnosis, and treatment
Curr Opin Infect Dis. 2023 Sep 22. doi: 10.1097/QCO.0000000000000976. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Mucormycosis (MCR) is a common opportunistic mold infection, and Mucorales were recently designated by WHO as priority pathogens. The interest in this infection has risen significantly since the major outbreak of MCR in the context of the COVID-19 pandemic, particularly in India. Herein, we summarize recently (last 24 months) published information regarding clinical aspects of MCR.RECENT FINDINGS: The disease remains protean in its clinical presentation, difficult to diagnose, and challenging to treat. In ...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Natalie J M Dailey Garnes Dimitrios P Kontoyiannis Source Type: research
Construction, evaluation, and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environmental pollutants
CONCLUSIONS: EpPRSs can serve as a proxy for assessing pollutant internal exposure. The application of the EpPRS to disease risk assessment can reveal the toxic pathway and mode of action linking exposure and disease in detail, providing a basis for the development of environmental pollutant control strategies.PMID:37734146 | DOI:10.1016/j.envint.2023.108202
Source: Environment International - September 21, 2023 Category: Environmental Health Authors: Silu Chen Junyi Xin Zhutao Ding Lingyan Zhao Shuai Ben Rui Zheng Shuwei Li Huiqin Li Wei Shao Yifei Cheng Zhengdong Zhang Mulong Du Meilin Wang Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
Immunomodulatory activity of dipeptidyl peptidase-4 inhibitors in immune-related diseases
This article is protected by copyright. All rights reserved.PMID:37732495 | DOI:10.1002/eji.202250302
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Marija Drakul Miodrag Čolić Source Type: research
Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetes Mellitus Undergoing Treatment with Sodium-Glucose Cotransporter 2 Inhibitors (EAGLE-DH)
CONCLUSION: Esaxerenone effectively lowered BP, was safe, and showed renoprotective effects in hypertensive patients with diabetes mellitus receiving treatment with SGLT2 inhibitors. Esaxerenone and SGLT2 inhibitors did not interfere with either drug's efficacy and may reduce the frequency of serum potassium elevations, suggesting they are a compatible combination.CLINICAL TRIAL REGISTRATION: jRCTs031200273.PMID:37733211 | DOI:10.1007/s12325-023-02633-8
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Hirohiko Motoki Yoshito Inobe Toshiki Fukui Arata Iwasaki Shinya Hiramitsu Sekiya Koyama Izuru Masuda Noriyuki Sekimura Kazuya Yamamoto Ai Sato Mitsuhisa Komatsu Takashi Taguchi Kazuhito Shiosakai Kotaro Sugimoto Koichiro Kuwahara Source Type: research
Prevention of cardiovascular disease in young adults: Focus on gender differences. A collaborative review from the EAS Young Fellows
Atherosclerosis. 2023 Sep 19:117272. doi: 10.1016/j.atherosclerosis.2023.117272. Online ahead of print.ABSTRACTA steady rise in cardiovascular morbidity and mortality has been observed in young adults within the last decades. This trend corresponds to an increasing prevalence of traditional cardiovascular risk factors such as obesity and diabetes mellitus type 2 among young adults living in developed countries. Moreover, age-specific risk factors, such as substance abuse, contraceptive medication, and pregnancy-related diseases also correlate with an increased incidence of cardiovascular diseases. In this review, we discus...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Christina Antza Antonio Gallo Chrysoula Boutari Alexandra Ershova Kadri Murat Gurses Joanna Lewek Mirakhmadjon Mirmaksudov G ünther Silbernagel Joakim Sandstedt Anna Lebedeva Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
Gut microbiota regulation of inflammatory cytokines and microRNAs in diabetes-associated cognitive dysfunction
Appl Microbiol Biotechnol. 2023 Sep 21. doi: 10.1007/s00253-023-12754-3. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) has a major comorbidity known as diabetes-associated cognitive dysfunction (DACD). Studies have demonstrated that the gut microbiota is crucial in mediating the cognitive abnormalities that occur in diabetic individuals. Additionally, changes in dietary fatty acid intake levels, inflammatory cytokines, and microRNAs (miRs) have an effect on cognitive performance. However, further studies are needed to identify the link between gut microbiota and cognition in T2DM patients and the role that ...
Source: Applied Microbiology and Biotechnology - September 21, 2023 Category: Microbiology Authors: Hongying Huang Tong Zhao Jinchen Li Jingyi Shen Rong Xiao Weiwei Ma Source Type: research
Effect of physical exercise combined with shockwave therapy on erectile dysfunction in diabetic patients
CONCLUSIONS: The combined approach of ESWT and PE provides significant advantages in erectile dysfunction improvement and durability as compared to ESWT or PE alone in diabetic patients with ED.PMID:37732055 | PMC:PMC10508044 | DOI:10.5114/aoms/135634
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Amr B Salama Mohamed Samy Abdrabo Walid A Abouelnaga Source Type: research
Immunomodulatory activity of dipeptidyl peptidase-4 inhibitors in immune-related diseases
This article is protected by copyright. All rights reserved.PMID:37732495 | DOI:10.1002/eji.202250302
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Marija Drakul Miodrag Čolić Source Type: research
