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Total 20 results found since Jan 2013.

Unwinding the modalities of necrosome activation and necroptosis machinery in neurological diseases
Ageing Res Rev. 2023 Jan 18:101855. doi: 10.1016/j.arr.2023.101855. Online ahead of print.ABSTRACTNecroptosis, a regulated form of cell death, is involved in the genesis and development of various life-threatening diseases, including cancer, neurological disorders, cardiac myopathy, and diabetes. Necroptosis initiates with the formation and activation of a necrosome complex, which consists of RIPK1, RIPK2, RIPK3, and MLKL. Emerging studies has demonstrated the regulation of the necroptosis cell death pathway through the implication of numerous post-translational modifications, namely ubiquitination, acetylation, methylatio...
Source: Ageing Research Reviews - January 21, 2023 Category: Genetics & Stem Cells Authors: Rohan Gupta Smita Kumari Rahul Tripathi Rashmi K Ambasta Pravir Kumar Source Type: research

TSAb Modulates Microglia M1 Polarization via Activation of the TSHR-Mediated NF- κB Signaling Pathway
Conclusions: TSAb can induce abnormal activation of microglia, polarize to the M1 phenotype, and promote the inflammatory cascade reaction, in which TSHR plays a key role in NF- κB activation and proinflammatory cytokine release.
Source: Neuroendocrinology - November 28, 2022 Category: Endocrinology Source Type: research

The Impact of Resistance Exercise on Muscle Mass in Glioblastoma in Survivors (RESIST): Protocol for a Randomized Controlled Trial
CONCLUSIONS: This study will inform how individualized circuit-based resistance training may improve functional independence and overall QOL of glioblastoma patients.TRIAL REGISTRATION: ClinicalTrails.gov NCT05116137; https://www.clinicaltrials.gov/ct2/show/NCT05116137.INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/37709.PMID:35507403 | DOI:10.2196/37709
Source: Cancer Control - May 4, 2022 Category: Cancer & Oncology Authors: Melanie R Keats Scott A Grandy Christopher Blanchard Jonathon R Fowles Heather F Neyedli Adrienne C Weeks Mary V MacNeil Source Type: research

Pneumocystis jirovecii Pneumonia in Neurologic Disorders: Is Prophylaxis Necessary?
Conclusions The overall incidence of PJP in patients with non-neoplastic neurologic disorders is exceedingly low, raising doubt about the value of routine PJP prophylaxis in neurologic patients outside neuro-oncology. PJP infection occurs frequently in patients with malignancy or parenchymal organ failure, indicating that overall health status may serve as a predisposing factor for PJP.
Source: Neurology Clinical Practice - June 7, 2021 Category: Neurology Authors: Pike-Lee, T., Syed, S., Willis, M. A., Li, Y. Tags: Autoimmune diseases, Fungal infections, Myasthenia, Primary brain tumor Research Source Type: research

Pembrolizumab-Induced Isolated Cranial Neuropathy: A Rare Case Report and Review of Literature
Conclusion: N-irAEs are insidious conditions that require solid knowledge of onco-immunotherapy complications: it is mandatory not to delay any treatment that would potentially modify the course of a neurological complication.
Source: Frontiers in Neurology - May 11, 2021 Category: Neurology Source Type: research

Checkpoint inhibitor –induced autoimmune central nervous system disorder in patients with metastatic melanoma and Hodgkin’s lymphoma
ConclusionsWe demonstrate that symptoms of immune checkpoint inhibitor –induced encephalitis can be unspecific, and radiological findings are often inconspicuous. Thus, cerebrospinal fluid analysis is the most important examination to achieve a correct diagnosis, which in turn is decisive for a rapid start of therapy.
Source: Clinical and Experimental Neuroimmunology - March 11, 2021 Category: Neurology Authors: Nora M öhn, Kurt‐Wolfram Sühs, Yenny Angela, Martin Stangel, Philipp Ivanyi, Gernot Beutel, Ralf Gutzmer, Thomas Skripuletz, Imke Grimmelmann Tags: ORIGINAL ARTICLE Source Type: research

Checkpoint inhibitor induced autoimmune central nervous system disorder in patients with metastatic melanoma and Hodgkin lymphoma
ConclusionsWe demonstrate that symptoms of immune checkpoint inhibitor induced encephalitis can be unspecific and radiological findings are often inconspicuous. Thus, cerebrospinal fluid analysis is the most important examination to achieve a correct diagnosis which in turn is decisive for a rapid start of therapy.
Source: Clinical and Experimental Neuroimmunology - February 15, 2021 Category: Neurology Authors: Nora M öhn, Kurt‐Wolfram Sühs, Yenny Angela, Martin Stangel, Philipp Ivanyi, Gernot Beutel, Ralf Gutzmer, Thomas Skripuletz, Imke Grimmelmann Tags: ORIGINAL ARTICLE Source Type: research

Modification of Neuromuscular Junction Protein Expression by Exercise and Doxorubicin
Conclusion Therefore, upregulating neurotrophic factor and NMJ protein expression may be an effective strategy to prevent DOX-induced skeletal muscle dysfunction.
Source: Medicine and Science in Sports and Exercise - June 16, 2020 Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research

Sarcoidosis and the Nervous System
This article provides an overview and update on the neurologic manifestations of sarcoidosis. RECENT FINDINGS The 2018 Neurosarcoidosis Consortium diagnostic criteria emphasize that biopsy is key for diagnosis and determines the level of diagnostic certainty. Thus, definite neurosarcoidosis requires nervous system biopsy and probable neurosarcoidosis requires biopsy from extraneural tissue. Without biopsy, possible neurosarcoidosis can be diagnosed if the clinical, imaging, and laboratory picture is compatible and other causes are ruled out. Recent large retrospective studies from the United States and France establishe...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Quantitative ultrasound of muscle can detect corticosteroid effects.
CONCLUSIONS: These findings suggest that QUS may be able to quantify skeletal muscle alterations associated with chronic corticosteroid use. Further study of this approach is warranted. SIGNIFICANCE: The findings of this study may provide a tool to evaluate corticosteroid myopathy. PMID: 31122815 [PubMed - as supplied by publisher]
Source: Clinical Neurophysiology - May 9, 2019 Category: Neurology Authors: Martucci MG, McIlduff CE, Shin C, Gutierrez HV, Nam JY, Greenstein P, Phillips K, Uhlmann EJ, Wong ET, Rutkove SB Tags: Clin Neurophysiol Source Type: research

Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis
Discussion Our main finding is that LAG-3 and TIM-3 expression levels in the PBMCs of MS patients can aid to predict disease outcome. Lower LAG-3 and TIM-3 expression were associated with the worst outcome and increased likelihood to progress to SPMS, while higher LAG-3 and TIM-3 expression correlated significantly with benign prognosis, persisting RRMS, and lower EDSS score at 10 years after blood sampling. Analysis of the paraclinical and clinical parameters baseline brain MRI T2LV, EDSS at diagnosis, and 1-year progression index combined with LAG-3 and TIM-3 expression levels resulted in superior ability to identify pa...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

PD-1 Inhibitor-associated Myopathies: Emerging Immune-mediated Myopathies
Programmed death-1 (PD-1) inhibitors are increasingly used in cancer immunotherapy. Various immune-related adverse events are reported, including infrequent individual case reports of myositis or rhabdomyolysis. The frequency and diagnostic spectrum of immune-related adverse events affecting skeletal muscle in PD-1 inhibitor-treated patients are unknown. We searched the Mayo Clinic Pharmacy database (2014–2016) to identify patients who developed myopathies during or after PD-1 inhibitor therapy. Among 654 cancer patients received PD-1 inhibitors (pembrolizumab=389; nivolumab=264; both=1), we identified 5 patients (pembro...
Source: Journal of Immunotherapy - April 21, 2018 Category: Allergy & Immunology Tags: Clinical Studies Source Type: research

Genome-wide Association Study of Susceptibility to Particulate Matter –Associated QT Prolongation
Conclusions: The findings suggest that biologically plausible genetic factors may alter susceptibility to PM10-associated QT prolongation in populations protected by the U.S. Environmental Protection Agency’s National Ambient Air Quality Standards. Independent replication and functional characterization are necessary to validate our findings. https://doi.org/10.1289/EHP347 Received: 11 April 2016 Revised: 07 September 2016 Accepted: 19 September 2016 Published: 08 June 2017 Address correspondence to R. Gondalia, Department of Epidemiology, University of North Carolina, 137 E. Franklin St., Chapel Hill, NC 27514. Te...
Source: EHP Research - June 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research