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Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders
Cell Mol Neurobiol. 2023 Feb 8:1-22. doi: 10.1007/s10571-023-01324-w. Online ahead of print.ABSTRACTMelatonin is ubiquitous molecule with wide distribution in nature and is produced by many living organisms. In human beings, pineal gland is the major site for melatonin production and to lesser extent by retina, lymphocytes, bone marrow, gastrointestinal tract, and thymus. Melatonin as a neurohormone is released into circulation wherein it penetrates all tissues of the body. Melatonin synthesis and secretion is supressed by light and enhanced by dark. Melatonin mostly exerts its effect through different pathways with melato...
Source: Cellular and Molecular Neurobiology - February 8, 2023 Category: Cytology Authors: Sheikh Bilal Ahmad Aarif Ali Midhat Bilal Shahzada Mudasir Rashid Amir Bashir Wani Rahil Razak Bhat Muneeb U Rehman Source Type: research

Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity. A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 3rd 2020
In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - February 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

The use of aloe vera in cancer radiation: An updated comprehensive review.
CONCLUSIONS: There is contradictory evidence for the use of aloe vera in the setting of radiation in regards to its efficacy in the prevention and treatment of radiation-induced adverse effects. PMID: 31003648 [PubMed - in process]
Source: Clinical Breast Cancer - April 22, 2019 Category: Cancer & Oncology Authors: Farrugia CE, Burke ES, Haley ME, Bedi KT, Gandhi MA Tags: Complement Ther Clin Pract Source Type: research

Astragalin Promotes Osteoblastic Differentiation in MC3T3-E1 Cells and Bone Formation in vivo
This study was carried out in accordance with the recommendations of the NIH guidelines for the care and use of laboratory animals. The protocol was approved by the Committees of Animal Ethics and Experimental Safety of Binzhou Medical University. Author Contributions DL supervised the whole project. LL, DW, and DL performed the major research and wrote the manuscript with equal contributions. YQ, MX, LZ, WX, XL, and LY provided technical support. SY and QZ provided their professional expertise. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financ...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for ...
Source: Frontiers in Psychiatry - April 8, 2019 Category: Psychiatry Source Type: research

Phytochemical screening, antioxidant, anti-inflammatory and antiangiogenic activities of Lophira procera A. Chev. (Ochnaceae) medicinal plant from Gabon
The objective of this study was to perform phytochemical screening, to determine the content of phenolic compound, to evaluate antioxidant, anti-inflammatory and antiangiogenic activities of ethanol, water-ethanol and water extracts of Lophira procera. Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and phosphomolybdenum assay, anti-inflammatory activity by proteins denaturation inhibition and membranes stabilization test and antiangiogenic activity by chicken chorioallantoic membrane (CAM) method. The results showed that this plant is rich in saponins, polyphenols, tannins, total flavonoids, pr...
Source: Egyptian Journal of Basic and Applied Sciences - July 11, 2018 Category: Science Source Type: research

A double-blind, randomised trial of a polyphenolic-rich nail bed balm for chemotherapy-induced onycholysis: the UK polybalm study
ConclusionThe polyphenolic-rich essential oils and plant-based waxes in this nail bed balm profoundly reduced chemotherapy-related nail damage and improved nail-related quality of life, compared to a control. A further analysis is planned combining this balm with nail bed cooling.
Source: Breast Cancer Research and Treatment - May 7, 2018 Category: Cancer & Oncology Source Type: research

Cognitive Impairment Associated with Cancer: A Brief Review
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research

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