Cognitive Impairment Associated with Cancer: A Brief Review

CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but not well understood due, in part, to marked differences in the research methods and definitions used for evaluating cognitive functioning in these patients. Most studies have identified attention, memory, and information processing as the most frequent cognitive domains impacted by cancer and cancer-related treatments, but further research clearly is needed. Recent efforts have been made to develop common definitions to define cognitive impairment in cancer patients and to suggest guidelines for the most appropriate cognitive tests to be used. Cognitive function has increasingly been recognized as a requisite therapeutic target in many diseases, including cancer. The extent of cognitive impairment that is observed in patients with cancer and those in remission make cognitive functioning a particularly important target for clinical trials and clinical practi...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research

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The immune cells of the brain are somewhat different in character and function from those of the body. They have a greater portfolio of tasks beyond chasing down pathogens, clearing out waste, and assisting in regeneration. For example, the immune cells known as microglia are involved in the maintenance of synaptic connections between neurons. Interestingly, microglia are not produced in the bone marrow by stem cells or progenitor cells, so in the research here in which young bone marrow is transplanted into old mice, one can be fairly sure that any beneficial effects on microglia result from signaling differences on the p...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
A study of more than 90,000 British adults by the University of East Anglia also found that gay men are 28 per cent less likely to be overweight or obese than their straight counterparts.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Heart rate variability is now well-established as a means to assess autonomic nervous system (ANS) control by analyzing the beat-to-beat variability over time of consecutive heart beats. The R-R intervals are mathematically transformed and depicted as power spectra within different frequency domains. Low frequency reflects both sympathetic and parasympathetic activity, high frequency reflects parasympathetic activity, and total power reflects overall autonomic activity. These analyses have been applied to a wide range of clinical conditions, and investigators have studied maturation of ANS control in preterm and term infan...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
Cain MR, Arkilo D, Linabery AM, Kharbanda AB. Emergency Department Use of Neuroimaging in Children and Adolescents Presenting with Headache. J Pediatr 2018;201:196-201.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Current Best Evidence Source Type: research
Consider this practice scenario: A skilled long-term care facility patient with severe dementia tells a registered dietitian nutritionist that she no longer wants to be fed via her gastrostomy feeding tube. She has no advanced directive. The resident ’s daughter wants her mother to be fed.1
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Practice Applications Source Type: research
LUNG cancer symptoms include a cough the won ’t go away, unexplained weight loss and severe chest pain. But you could also be at risk of deadly lung tumour signs if your eyes are a distinctive colour.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
While medicine transforms cancer into a chronic disease with which patients can live for an extended period of time, financial toxicity threatens to turn chronic, too.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Health Insurance and Managed Care Drugs (Pharmaceuticals) Bankruptcies Cancer Source Type: news
Authors: Simons M, Schraut N, Moretti V, Klazura G, Chuang D, Parekh A, Gonzalez M Abstract The goal of this study was to define the course of the popliteal artery (PA) and determine any variability among different patient demographics; by identifying risk factors for injury, surgeons can decrease patient morbidity and mortality. Ninety-four adult magnetic resonance imaging studies of the knee were reviewed. In extension, the artery is at most 7.87 mm posterior and 4.83 mm lateral to the midline below the tibial plateau. Proximally, the artery is more anterior and midline. With increasing body mass indexes, the art...
Source: Journal of surgical orthopaedic advances - Category: Orthopaedics Tags: J Surg Orthop Adv Source Type: research
This study supports the use of ASC facilities to achieve efficient resource use in the operative treatment of~total ankle arthroplasties (Journal of Surgical Orthopaedic Advances 27(4):321-324, 2018). PMID: 30777835 [PubMed - in process]
Source: Journal of surgical orthopaedic advances - Category: Orthopaedics Tags: J Surg Orthop Adv Source Type: research
This study evaluated the impact of fluoroscopically guided percutaneous bone biopsy on altering antibiotic regimens in lower extremity osteomyelitis. Eighty-eight patients who received fluoroscopically guided bone biopsies were identified. There was bacterial growth in 28% of bone biopsies overall. The rate of positive culture was decreased in patients started on empiric antibiotics before biopsy (23%) compare with patients without empiric antibiotics (44%). Antibiotic regimens were changed in 24% of patients overall in response to culture data. The majority of positive biopsy cultures (76%) but minority of negative biopsy...
Source: Journal of surgical orthopaedic advances - Category: Orthopaedics Tags: J Surg Orthop Adv Source Type: research
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