Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions

Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for osteoporosis, the mechanisms that may link these conditions, and potential implications for treatment. Traditional, alternative, and adjunctive therapies are discussed. This review is not intended to provide therapeutic recommendations, but, rather, the goal of this review is to delineate potential interactions of psychological stress and osteoporosis and to highlight potential multi-system implications of pharmacological interventions. Review of the current literature identifies several potentially overlapping mechanistic pathways that may be of interest (e.g., glucocorticoid signaling, insulin-like growth factor signaling, serotonin signaling) for further basic and clinical research. Current literature also supports the potential for cross-effects of therapeutics...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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Publication date: Available online 20 October 2019Source: European Journal of RadiologyAuthor(s): Chuqian Lei, Wei Wei, Zhenyu Liu, Qianqian Xiong, Ciqiu Yang, Mei Yang, Liulu Zhang, Teng Zhu, Xiaosheng Zhuang, Chunling Liu, Zaiyi Liu, Jie Tian, Kun WangAbstractPurposeWe developed and validated a radiomic model based on mammography and assessed its value for predicting the pathological diagnosis of Breast Imaging Reporting and Data System (BI-RADS) category 4 calcifications.Materials and MethodsPatients with a total of 212 eligible calcifications were recruited (159 cases in the primary cohort and 53 cases in the validatio...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 20 October 2019Source: Journal of Vocational BehaviorAuthor(s): Emmanuelle Vignoli, Nathalie Prudhomme, Katia Terriot, Valérie Cohen-Scali, Caroline Arnoux-Nicolas, Jean-Luc Bernaud, Noëlle LallemandAbstractThe first aim of this study was to validate a French version of the Decent Work Scale (DWS) proposed by Duffy, Allan, Blustein, England, Douglass, Ferreira, and Santos (2017). Our second aim was to gain insight into French people's representations of decent work using a qualitative approach. A representative sample of 300 French employees completed the DWS, as well as measu...
Source: Journal of Vocational Behavior - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Eliana Vassena, Filip Van Opstal, Ingeborg Goethals, Tom VergutsAbstractThe ability to exert control has been widely investigated as a hallmark of adaptive behaviour. Dopamine is recognized as the key neuromodulator mediating various control-related processes. The neural mechanisms underlying the subjective perception of being in control, or Locus of Control (LOC) are however less clear. LOC indicates the subjective tendency to attribute environmental outcomes to one's actions (internal LOC) or instead to external ...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Conversations and healthy debate about issues facing our industry and the health care system are critical to addressing some of today ’s challenges and opportunities. The Catalyst welcomes guest contributors, including patients, stakeholders, innovators and others, to share their perspectives and point of view. Views represented here may not be those of PhRMA, though they are no less key to a healthy dialogue on issues in health care today.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: diabetes Out of Pocket Costs Voters for Cures Source Type: news
ConclusionsThe relevance of SPARC expression in pancreato-biliary carcinomas though may still be important for therapeutic decision making, it is not responsible for peritumoral stromal desmoplasia in these tumors and it does not have any significant prognostic implication.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Objective: To compare the rate of malreduction after high fibular fractures associated with syndesmosis injury treated with open reduction and internal fixation, with either 2 screws or 1 knotless TightRope device. Design: Prospective randomized controlled multicenter trial. Setting: Eleven academic and community hospitals including Level 1 and Level 2 trauma centers across Canada. Patients/Participants: One hundred three patients with OTA/AO 44-C injuries with demonstrated radiographic syndesmosis diastasis or instability after malleolar bony fixation were followed for 12 months after treatment. Methods: Ope...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusions: Results suggest TCC may have a small positive effect on early outcomes, but use of the services was highly variable among sites. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Conclusions: We observed a significant inverse relationship between surgeon volume and complication rates when controlling for patient and injury characteristics. In contrast to previous research, a volume–outcome relationship was not observed at the hospital level. These results suggest that such complex injuries should be triaged to the most experienced providers. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Authors: Arezoomandan R, Aliaghaei A, Khodagholi F, Haghparast A Abstract Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 signif...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
This study explored the association between serum vitamin D levels and urinary tract infections in pregnant women.Study designIn this case control study, 187 participants including, 97 pregnant women diagnosed as a symptomatic UTI (case group) and 90 matched healthy pregnant women (control group) were consecutively enrolled from prenatal care clinic of Imam Reza Hospital in Urmia, North West of Iran. The two groups were matched for trimester and parity, and sexual intercourse. Blood samples were collected from both groups. Chemiluminescent immunoassay (CLIA) was used to evaluate the serum vitamin D levels. We used a binary...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
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