Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions

Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for osteoporosis, the mechanisms that may link these conditions, and potential implications for treatment. Traditional, alternative, and adjunctive therapies are discussed. This review is not intended to provide therapeutic recommendations, but, rather, the goal of this review is to delineate potential interactions of psychological stress and osteoporosis and to highlight potential multi-system implications of pharmacological interventions. Review of the current literature identifies several potentially overlapping mechanistic pathways that may be of interest (e.g., glucocorticoid signaling, insulin-like growth factor signaling, serotonin signaling) for further basic and clinical research. Current literature also supports the potential for cross-effects of therapeutics...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

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The Substance Abuse and Mental Health Services Administration of the U.S. Department of Health and Human Services has awarded an $11.8 million grant to the Hawaii State Department of Health's Child and Adolescent Mental Health Division, or CAMHD, officials announced Wednesday. The four-year grant will focus on enhancing services for approximately 2,400 Hawaii youth, between the ages of three and 21, with "serious emotional disturbance" each year. The goals of the expansion grant, also described…
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We present the case of a 29 year old woman who started with pain, redness and blurred vision after a holiday in Singapore and did not respond to conjunctivitis treatment. PCR sequencing and PAS staining of corneal epithelial biopsy identified Vittaforma corneae as the causative organism. Treatment was initiated with corneal debridement, oral albendazol, and intensive topical voriconazole, levofloxacin and propamidine, but the conjunctival and corneal disease was only resolved 5 months later with the introduction of topical steroids to treat her severe limbitis. Suspicion of Microsporidium keratoconjunctivitis should be rai...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Tripta Bhatia, Tom Robinson, Rumiana Dimova We use a microfluidic method to estimate the water permeability coefficient (p) of membranes. As model lipid membranes we employ giant unilamellar vesicles (GUVs) composed of palmitoyloleoyl phosphatidylcholine and cholesterol... The content of this RSS Feed (c) The Royal Society of Chemistry
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New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ06458C, PaperYanfei Li, Hui Li, Guilan Di As the most important representatives of reactive oxygen species (ROS), hypochlorous acid (HClO) is crucial for maintaining the homeostasis in cells and play vital roles in many physiological and pathological... The content of this RSS Feed (c) The Royal Society of Chemistry
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Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC03726E, CommunicationAtul Kumar, Mohd Yeshab Ansari, sumedha swarnkar The stereoselective Sulfur-Nitrogen difunctionalization (aminosulfonylation) across the alkynes framework in a syn mode is accomplished using sodium sulfinates and azoles, in the presence of I2/base. This strategy is applicable to... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Authors: Bacardit Guardiola M, Delás Amat J PMID: 32660721 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
If Tokyo Games don ’t go ahead,Beijing 2022 also likely to be cancelled;Dr Fauci predicts US will meet vaccine target;Bolsonaro tests positive againGlobal report: Bangladesh hospital owner accused of faking test resultsFamily fortunes of super rich increase during pandemicUK coronavirus updates - live8.24amBSTIf the postponedTokyo Olympics do not go ahead next year due to Covid-19 then the 2022 Beijing Winter Games is also likely to be cancelled, according to long-time International Olympic Committee member Dick Pound. Reuters reports:The Beijing Winter Olympics are scheduled for Feb. 4 to 20, 2022, just six months a...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: World news Coronavirus outbreak Science Infectious diseases UK news US news Australia news Microbiology Medical research Source Type: news
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Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Anesthesiology Journal Article Source Type: news
In this study, we aimed to examine the effects of anakinra on morphine analgesia and tolerance. MATERIALS AND METHODS: In this study, 36 Wistar Albino (230-250 g) male rats were used. Animals were divided into six groups: Saline (S), 100 mg/kg anakinra (A), 5mg/kg morphine (M), M+A, morphine tolerance (MT) and MT+A. The resulting analgesic effect was measured with hot plate and tail flick analgesia tests. After analgesia tests the dorsal root ganglions (DRG) tissues were removed. Oxidative stress parameters [total antioxidant status (TAS), total oxidant status (TOS)], endoplasmic reticulum (ER) stress and apoptosis pro...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
CONCLUSION: MG ameliorates arthritis via actions on inflammatory ways and wingless (Wnt) signaling pathway. These results suggest that MG may have a considerable potential efficacy for the treatment of rheumatoid arthritis. PMID: 32659877 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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