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Total 380 results found since Jan 2013.

d-dimer and diffusion-weighted imaging pattern as two diagnostic indicators for cancer-related stroke: A case–control study based on the STROBE guidelines
The aim of this study was to evaluate the risk factors and elucidate the clinical characteristics of cancer-associated ischemic stroke to differentiate it from conventional ischemic stroke in China and East Asia. Between June 2012 and June 2016, a retrospective analysis was performed on 609 stroke patients with cancer. They were divided into 3 groups: cancer-stroke group (CSG, 203 cases), stroke group (SG, 203 cases), and cancer group (CG, 203 cases). The d-dimer levels and diffusion-weighted imaging lesion (DWI) pattern were compared to an age- and sex-matched control group. The most common cancer types were colorectal ca...
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Efficacy of Aspirin in the Primary Prevention of Cardiovascular Diseases and Cancer in the Elderly: A Population-Based Cohort Study in Korea
ConclusionAspirin reduced the risks of MACCE and cancer without increasing the bleeding risk in elderly Koreans with hypertension, T2DM, or dyslipidemia. Moreover, the benefits of the long-term use of aspirin in reducing the risks of MACCE were demonstrated. However, the decision of using aspirin for primary prevention must be carefully made on an individual basis, while estimating the benefit –risk balance of aspirin.
Source: Drugs and Aging - November 21, 2019 Category: Geriatrics Source Type: research

Incidence rates of cardiovascular outcomes in a community ‐based population of cancer patients
ConclusionsIn a population of patients with cancer not exposed to TKIs, cardiovascular risk factors and outcomes are very common, regardless of cancer type. These data can inform the evaluation of potential excess cardiovascular risks from new interventions.
Source: Cancer Medicine - October 29, 2019 Category: Cancer & Oncology Authors: Rajeev Masson, Lina Titievsky, Douglas A. Corley, Wei Zhao, Alfredo R. Lopez, Jennifer Schneider, Jonathan G. Zaroff Tags: ORIGINAL RESEARCH Source Type: research

Treatment of hypertension in old patients without previous cardiovascular disease
Conclusion: Blood pressure levels lower than those currently recommended are not harmful among older patients. The association between lower SBP and lesser risk of CVD may instead suggest a beneficial effect of lower SBP.
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Statins: Complex outcomes but increasingly helpful treatment options for patients.
Abstract Statins are long known class of medicines and the most frequently prescribed drugs in cardiovascular pharmacotherapy, widely ordered not only in patients suffering from dyslipidemia, but also in patients with coronary artery disease, acute coronary syndromes, diabetes mellitus, stroke, hypertension, and chronic kidney disease, with or without coexisting dyslipidemia. However, several clinical trials have shown, that the advantages of statins goes beyond their reduction of the cholesterol level. Some crucial isoprenoid mediators which are highly essential for the activation of different intracellular/signa...
Source: European Journal of Pharmacology - September 26, 2019 Category: Drugs & Pharmacology Authors: Mohammadkhani N, Gharbi S, Fatima H, Farzaneh A, Mahjoob G, Hoseinsalari A, Korsching E Tags: Eur J Pharmacol Source Type: research

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

In vitro antioxidant, 𝛼-amylase and 𝛼-glucosidase activities of methanol extracts from three Momordica species
AbstractAntioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer ’s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and 𝛼-amyla se and glucosidase inhibitors. Although several biological activities had been reported for MomordicafoetidaandMomordicacharantia; it appears there is limited info...
Source: International Journal of Phytomedicine - August 25, 2019 Category: Science Authors: Olubunmi Adenike Akinwunmi Source Type: research

In vitro antioxidant, α-amylase and α-glucosidase activities of methanol extracts from three Momordica species
AbstractAntioxidant based drug preparations are used in the prevention and management of complex diseases which include atherosclerosis, stroke, diabetes, alzheimer ’s disease and cancer. Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this ailment, which may be achieved through the use of oral hypoglycemic drugs such as biguanides, insulin secretagogues, and 𝛼-amyla se and glucosidase inhibitors. Although several biological activities had been reported for MomordicafoetidaandMomordicacharantia; it appears there is limited info...
Source: International Journal of Phytomedicine - August 25, 2019 Category: Science Authors: Oubunmi Adenike Akinwunmi Source Type: research

Interactions of Behavioral Changes in Smoking, High-risk Drinking, and Weight Gain in a Population of 7.2 Million in Korea.
Conclusions: These results obtained using a large-scale population-based database documented interactions among lifestyle factors over time. PMID: 31396377 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - August 11, 2019 Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research

Assessing global COPD awareness with Google Trends
Although chronic obstructive pulmonary disease (COPD) prevalence and mortality rates rise continuously, patients often remain undiagnosed, probably due to a lack of disease-related awareness. The aim of this study was to quantify public interest in COPD by analysing the frequency of web queries via Google. Data from 2004 to 2018 were collected using the search engine query data analysis tool Google Trends. The relative search volume of the topic "chronic obstructive pulmonary disease" was compared with the relative search volume of nine topics representing the major causes of death in high-income countries according to the...
Source: European Respiratory Journal - June 26, 2019 Category: Respiratory Medicine Authors: Boehm, A., Pizzini, A., Sonnweber, T., Loeffler-Ragg, J., Lamina, C., Weiss, G., Tancevski, I. Tags: COPD and smoking Original Articles: COPD Source Type: research

Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality.
CONCLUSIONS: In this long-term prospective cohort study, higher baseline serum α-tocopherol biochemical status was associated with lower risk of overall mortality and mortality from all major causes. Our data support the long-term health benefits of higher serum α-tocopherol for overall and chronic disease mortality and should be replicated in other more diverse populations. PMID: 31219752 [PubMed - in process]
Source: Circulation Research - June 20, 2019 Category: Cardiology Authors: Huang J, Weinstein SJ, Yu K, Männistö S, Albanes D Tags: Circ Res Source Type: research

Tea Consumption and Health Outcomes: Umbrella Review of Meta ‐Analyses of Observational Studies in Humans
ConclusionTea consumption, except for very hot tea, seems generally safe at usual levels of intake, with summary estimates indicating the largest reduction for diverse health outcomes at two to three cups per day. Generally, tea consumption seems more beneficial than harmful in this umbrella review. Randomized controlled trials are further needed to understand whether the observed associations are causal.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - June 18, 2019 Category: Food Science Authors: Mengshi Yi, Xiaoting Wu, Wen Zhuang, Lin Xia, Yi Chen, Rui Zhao, Qianyi Wan, Liang Du, Yong Zhou Tags: Review Source Type: research

Prediction of 5-year risk of diabetes mellitus in relatively low risk middle-aged and elderly adults
ConclusionsFasting plasma glucose level, BMI, and triglyceride level were still dominated factors to predict 5-year diabetic risk among the relatively low risk participants. The cutoff values for fasting plasma glucose, TG, and BMI set as 5.89  mmol/L, 1.1 mmol/L, and 24 kg/m2, respectively, had the best predictive discrimination of diabetes.
Source: Acta Diabetologica - June 11, 2019 Category: Endocrinology Source Type: research

Body Mass Index and Prognosis in Ischemic Stroke Patients With Type 2 Diabetes Mellitus
This study showed the overall presence of the obesity paradox in stroke patients with T2DM. However, obese patients had different risks of cardiovascular events and stroke.
Source: Frontiers in Neurology - June 4, 2019 Category: Neurology Source Type: research