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Cancer: Gastric (Stomach) Cancer

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Total 1410 results found since Jan 2013.

Silencing Bmi-1 enhances the senescence and decreases the metastasis of human gastric cancer cells.
CONCLUSION: Silencing Bmi-1 by RNA interference can increase the senescent cell rate and effectively reduce the metastasis of gastric cancer cells. PMID: 24379598 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2013 Category: Gastroenterology Authors: Gao FL, Li WS, Liu CL, Zhao GQ Tags: World J Gastroenterol Source Type: research

Epithelial‐to‐mesenchymal transition predicts prognosis in clinical gastric cancer
ConclusionsEMT is a critical prognostic factor for gastric cancer. Zeb‐1 might be a promising therapeutic target. J. Surg. Oncol. © 2014 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - January 22, 2014 Category: Cancer & Oncology Authors: Toshifumi Murai, Suguru Yamada, Bryan C. Fuchs, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Kenneth K. Tanabe, Yasuhiro Kodera Tags: Research Article Source Type: research

EBNA1 Binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells
Conclusions: These findings demonstrate that EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes in GC cells, and suggest that EBNA1 contributes to the complex transcriptional and epigenetic deregulation of the GKN1 and GKN2 tumor suppressor genes in EBV positive GC.
Source: Virology Journal - January 24, 2014 Category: Virology Authors: Fang LuItalo TemperaHyunna LeeKaren DeWispelaerePaul Lieberman Source Type: research

IL-1beta-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9
Conclusions: IL-1beta-induced p38 activation and the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in GA; this pathway may provide a novel therapeutic target for GA.
Source: Molecular Cancer - January 31, 2014 Category: Cancer & Oncology Authors: Qiaojia HuangFenghua LanXiaoting WangYinghao YuXuenong OuyangFeng ZhengJunyong HanYoudong LinYanchuan XieFeilai XieWei LiuXiaoli YangHan WangLihong DongLie WangJianming Tan Source Type: research

COX-2 Signaling and Cancer: New Players in Old Arena.
Abstract Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins has not only been associated with various types of cancer but is also directly proportional to their aggressiveness including metastasis. Thus, inhibition of COX-2 activity has been one of the preferred targets for cancer reduction. Broad spectrum inhibition of all forms of COX (using NSAIDs) is associated with various side effects ranging from gastric ulceration to renal problems. Even specific COX-2 inhibitors (COXIBS) are associated with side effects like myocardial infarction. Alternative strategies including siRN...
Source: Current Drug Targets - January 26, 2014 Category: Drugs & Pharmacology Authors: Misra S, Sharma K Tags: Curr Drug Targets Source Type: research

MicroRNA-362 induces cell proliferation and apoptosis resistance in gastric cancer by activation of NF-¿B signaling
Conclusion: The results suggest that miR-362 plays an important role in repressing the tumor suppressor CYLD and present a novel mechanism of miRNA-mediated NF-κB activation in gastric cancer.
Source: Journal of Translational Medicine - February 5, 2014 Category: Research Authors: Jin-tang XiaLian-zhou ChenWei-hua JianKe-Bing WangYong-zhen YangWei-ling HeYu-long HeDe ChenWen Li Source Type: research

PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/Erk-dependent pathways.
In conclusion, these results indicate that PAK4 confers CDDP resistance via activation of MEK/Erk and PI3K/Akt pathways. PAK4 and PI3K/Akt pathways can reciprocally activate each other. Therefore, PAK4 may be a potential target for overcoming CDDP resistance in gastric cancer. PMID: 24471762 [PubMed - as supplied by publisher]
Source: Bioscience Reports - January 29, 2014 Category: Biomedical Science Authors: Fu X, Feng J, Zeng D, Ding Y, Yu C, Yang B Tags: Biosci Rep Source Type: research

Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells.
In this study, we first report the chemopreventive effect of chalcone in human gastric adenocarcinoma cell lines: AGS. The results showed that chalcone could inhibit the abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay, Boyden chamber invasion/migration assay, and wound-healing assay. Molecular data showed that the effect of chalcone in AGS cells might be mediated via sustained inactivation of the phosphorylation of focal adhesion kinase (FAK) and c-Jun N-terminal kinase 1 and 2 (JNK1/2) signal involved in the downregulation of the expressions of matrix metalloproteinase-2 (MMP-2) and matrix...
Source: Molecular and Cellular Biochemistry - February 9, 2014 Category: Biochemistry Authors: Lin SH, Shih YW Tags: Mol Cell Biochem Source Type: research

Phospholipase D1 and choline kinase-α are interactive targets in breast cancer.
Abstract A consistent metabolic hallmark observed in multiple cancers is the increase of cellular phosphocholine (PC) and total choline-containing compounds (tCho), which is closely related to malignant transformation, invasion, and metastasis. Enzymes in choline phospholipid metabolism present attractive targets to exploit for treatment, but require a clear understanding of the mechanisms underlying the altered choline phospholipid metabolism observed in cancer. Choline kinase-α (Chk-α) is an enzyme in the Kennedy pathway that phosphorylates free choline (Cho) to PC, and its upregulation in several cancers is a...
Source: Cancer Biology and Therapy - February 20, 2014 Category: Cancer & Oncology Authors: Gadiya M, Mori N, Cao MD, Mironchik Y, Kakkad S, Gribbestad IS, Glunde K, Krishnamachary B, Bhujwalla ZM Tags: Cancer Biol Ther Source Type: research

FOXO3a-mediated suppression of the self-renewal capacity of sphere-forming cells derived from the ovarian cancer SKOV3 cell line by 7-difluoromethoxyl-5,4'-di-n-octyl genistein.
Abstract Carcinogenesis is predominantly dependent on the cancer stem cells (CSCs) residing or populating within the cancer. We previously demonstrated that the novel synthetic genistein analogue, 7-difluoromethoxyl-5,4'-di-n-octylgenistein (DFOG), induced apoptotic cell death of ovarian and gastric cancer cells. The present study demonstrated that sphere‑forming cells (SFCs) derived from the ovarian cancer cell-line SKOV3 possessed ovarian cancer stem-like cell (OCSLC) properties, including self-renewal and high tumorigenicity. DFOG may be effective in inhibiting the self‑renewal capacity of SFCs derived from...
Source: Molecular Medicine - March 6, 2014 Category: Molecular Biology Authors: Ning Y, Luo C, Ren K, Quan M, Cao J Tags: Mol Med Rep Source Type: research

Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the {beta}-Catenin/TCF/LEF-1 pathway in gastric cancer cells
Glycogen synthase kinase 3 beta (GSK3β) is a critical protein kinase that phosphorylates numerous proteins in cells and thereby impacts multiple pathways including the β-Catenin/TCF/LEF-1 pathway. MicroRNAs (miRs) are a class of noncoding small RNAs of ~22 nucleotides in length. Both GSK3β and miR play myriad roles in cell functions including stem cell development, apoptosis, embryogenesis and tumorigenesis. Here we show that GSK3β inhibits the expression of miR-96, miR-182 and miR-183 through the β-Catenin/TCF/LEF-1 pathway. Knockout of GSK3β in mouse embryonic fibroblast cells increases expr...
Source: Nucleic Acids Research - March 11, 2014 Category: Research Authors: Tang, X., Zheng, D., Hu, P., Zeng, Z., Li, M., Tucker, L., Monahan, R., Resnick, M. B., Liu, M., Ramratnam, B. Tags: Gene Regulation, Chromatin and Epigenetics Source Type: research

Chk1, but not Chk2, is responsible for G2/M phase arrest induced by diallyl disulfide in human gastric cancer BGC823 cells.
Abstract Diallyl disulfide (DADS) has been shown to cause G2/M phase cell cycle arrest in several human cancers. Here we demonstrate a mechanism by which DADS induces G2/M phase arrest in BGC823 human gastric cancer cells via Chk1. From cell cycle gene array results, we next confirmed that cyclin B1 expression was decreased by DADS, while the expression of p21, GADD45α and p53 were increased. Despite the lack of change in Chk1 gene expression in response to DADS according to the array analysis, intriguingly overexpression of Chk1, but not Chk2, exhibited increased accumulation in G2/M phase. Moreover, overexpress...
Source: Food and Chemical Toxicology - March 17, 2014 Category: Food Science Authors: Bo S, Hui H, Li W, Hui L, Hong X, Lin D, Wen-Xiang D, You-Hua W, Xiao-Hong A, Hao J, Qi S Tags: Food Chem Toxicol Source Type: research

MGr1‐Ag/37LRP induces cell adhesion‐mediated drug‐resistance via FAK/PI3K and MAPK pathway in gastric cancer
This article is protected by copyright. All rights reserved.
Source: Cancer Science - April 7, 2014 Category: Cancer & Oncology Authors: Li Sun, Lili Liu, Xiangqiang Liu, Yafang Wang, Mengbin Li, Liping Yao, Jianjun Yang, Genlin Ji, Changcun Guo, Yanglin Pan, Shuhui Liang, Biaoluo Wang, Jie Ding, Hongwei Zhang, Yongquan Shi Tags: Original Article Source Type: research

Overexpression of SLC38A1 is associated with poorer prognosis in Chinese patients with gastric cancer
Conclusion: SLC38A1 is overexpressed in gastric cancer, which suggests that it is contributory to tumor progression. These results encourage the exploration of SLC38A1 as a target for intervention in gastric cancer.
Source: BMC Gastroenterology - April 9, 2014 Category: Gastroenterology Authors: Jing XiePing LiHui-feng GaoJian-xin QianLing-Yan YuanJie-jun Wang Source Type: research

Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells
ConclusionsThese data help unravel a crucial role for EZH2 in senescence and apoptosis in gastric cancer cells and that p53 genomic status was associated with different cell responses to EZH2 silencing.
Source: Cell Proliferation - April 16, 2014 Category: Cytology Authors: J. Bai, M. Ma, M. Cai, F. Xu, J. Chen, G. Wang, X. Shuai, K. Tao Tags: Original Article Source Type: research