EBNA1 Binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells

Conclusions: These findings demonstrate that EBNA1 binds to the divergent promoter of the GKN1 and GKN2 genes in GC cells, and suggest that EBNA1 contributes to the complex transcriptional and epigenetic deregulation of the GKN1 and GKN2 tumor suppressor genes in EBV positive GC.

http://www.virologyj.com/content/11/1/12

Source: Virology Journal - January 24, 2014 Category: Virology Authors: Fang LuItalo TemperaHyunna LeeKaren DeWispelaerePaul Lieberman Source Type: research