Impact of oral bisphosphonate drug holiday on mortality following hip fracture: a population-based cohort study
CONCLUSIONS: Post-fracture mortality is higher in people who discontinue risedronate, but not alendronate, for 1 or 2 years after being adherent to treatment for at least 5 years. The type of bisphosphonate may be a factor to consider when planning drug holidays.PMID:38630464 | DOI:10.1210/clinem/dgae272 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2024 Category: Endocrinology Authors: Miriam T Y Leung Justin P Turner Clara Marquina Jenni Ilomaki Tim Tran J Simon Bell Source Type: research
Retracted: Risedronate Effects on the In Vivo Bioactive Glass Behavior: Nuclear Magnetic Resonance and Histopathological Studies
Biomed Res Int. 2024 Mar 20;2024:9850640. doi: 10.1155/2024/9850640. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2019/2175731.].PMID:38550197 | PMC:PMC10977273 | DOI:10.1155/2024/9850640 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Retracted: Risedronate Effects on the In Vivo Bioactive Glass Behavior: Nuclear Magnetic Resonance and Histopathological Studies
Biomed Res Int. 2024 Mar 20;2024:9850640. doi: 10.1155/2024/9850640. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2019/2175731.].PMID:38550197 | PMC:PMC10977273 | DOI:10.1155/2024/9850640 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Cancers, Vol. 16, Pages 1256: EGFR-Targeted Antibody & ndash;Drug Conjugate to Different Aminobisphosphonates: Direct and Indirect Antitumor Effects on Colorectal Carcinoma Cells
In this study, we conjugated Cetuximab (Cet), a monoclonal antibody that targets the epidermal growth factor receptor (EGFR), to aminobisphosphonates (N-BPs) such as ibandronate (IBA) or risedronate (RIS) or zoledronate (ZA). Cetuximab is administered to patients with metastatic colorectal carcinoma (mCRC) with a wild-type (WT) EGFR transduction pathway. Also, it is well established that N-BPs can trigger the antitumor activity of Vδ2 T cells in both in vitro and in vivo experimental models. The resulting ADCs were added in co-culture to assess the effect on CRC cell line proliferation and sensitivity to V&am...
Source: Cancers - March 22, 2024 Category: Cancer & Oncology Authors: Pisheh Matis Taglieri Di Gregorio Benelli Poggi Tags: Article Source Type: research
Twelve-month resistance and impact exercise program or risedronate provides a relative benefit to hip bone structure in postmenopausal women: results from a randomized controlled trial
ConclusionExercise and bisphosphonates may influence structural and strength estimates at the hip, but not at peripheral sites (tibia). Neither exercise nor bisphosphonates were found to be superior in improving estimates of hip bone strength. (Source: Osteoporosis International)
Source: Osteoporosis International - February 17, 2024 Category: Orthopaedics Source Type: research
Role of zinc in health and disease
AbstractThis review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. Zinc cannot be stored in significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport dietary zinc ions from the duodenum i nto the enterocyte, ZnT1 transports zinc ions from the enterocyte into the circulation, and ZnT5B (bidirectional zinc transporter) facilitates endogenous zinc secretion into the intestinal lumen. Putative promoters of zinc absorption that increase its bioavailability includ...
Source: Clinical and Experimental Medicine - February 17, 2024 Category: Research Source Type: research
Twelve-month resistance and impact exercise program or risedronate provides a relative benefit to hip bone structure in postmenopausal women: results from a randomized controlled trial
ConclusionExercise and bisphosphonates may influence structural and strength estimates at the hip, but not at peripheral sites (tibia). Neither exercise nor bisphosphonates were found to be superior in improving estimates of hip bone strength. (Source: Osteoporosis International)
Source: Osteoporosis International - February 17, 2024 Category: Orthopaedics Source Type: research
Role of zinc in health and disease
AbstractThis review provides a concise overview of the cellular and clinical aspects of the role of zinc, an essential micronutrient, in human physiology and discusses zinc-related pathological states. Zinc cannot be stored in significant amounts, so regular dietary intake is essential. ZIP4 and/or ZnT5B transport dietary zinc ions from the duodenum i nto the enterocyte, ZnT1 transports zinc ions from the enterocyte into the circulation, and ZnT5B (bidirectional zinc transporter) facilitates endogenous zinc secretion into the intestinal lumen. Putative promoters of zinc absorption that increase its bioavailability includ...
Source: Clinical and Experimental Medicine - February 17, 2024 Category: Research Source Type: research
Denosumab, teriparatide and bisphosphonates for glucocorticoid-induced osteoporosis: a Bayesian network meta-analysis
Conclusion: Teriparatide denosumab and the bisphosphonates are all effective in improving BMD for GIO patients. Based on this network meta-analysis, teriparatide and denosumab have higher efficiency in improving lumbar spine and femur neck BMD, and reducing vertebrae fracture.Systematic Review Registration:10.17605/OSF.IO/2G8YA, identifier CRD42023456305. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 19, 2024 Category: Drugs & Pharmacology Source Type: research
Safety and effectiveness of risedronate in Paget ’s disease of bone: postmarketing surveillance study in Japan
ConclusionTo conclude, risedronate 17.5 mg/day is safe and effective for treating patients with PDB in daily practice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 10, 2024 Category: Orthopaedics Source Type: research
The effectiveness of ibandronate in reducing the risk of nonvertebral fractures in women with osteoporosis: systematic review and meta-analysis of observational studies
ConclusionResults suggest that once-monthly 150 mg oral ibandronate may be as effective as other oral bisphosphonates in reducing the risk of nonvertebral fractures. However, uncertainty associated to the small number of included studies, which are characterized by heterogeneous demographics and methodologies, precluded definitive conclusions. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 19, 2023 Category: Drugs & Pharmacology Source Type: research
Medication-related osteonecrosis of the jaw: A cross-sectional study on the prevalence of cutaneous manifestations and the primary care physician's role in its early diagnosis
Bone-modifying agents (BMA), such as nitrogen-containing bisphosphonates (N-BP) s)(e.g., zoledronic acid, pamidronate, alendronate and risedronate) and receptor activators of nuclear factor kappa- Β ligand inhibitors (e.g., denosumab), are commonly used for treating osteoporosis, bone metastases, and other bone-related diseases. Side effects of Stevens–Johnson syndrome and toxic epidermal necrolysis in patients using N-BPshave been reported.1 In addition, maculopapular lesions,2 plaques an d ulcerations,3 dermatitides, and B-cell pseudolymphoma4 were reported in patients taking zoledronic acid. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - November 30, 2023 Category: General Medicine Authors: Sara Whitefield, Mor Bar Ilan, Towy Sorel Lazarovici, Silvina Friedlander-Barenboim, Riad Kassem, Yarom Noam Tags: Clinical Research Study Source Type: research
What is the role of risedronate in the primary and secondary prevention of fractures associated with osteoporosis in postmenopausal women? A Cochrane review summary with commentary
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - October 31, 2023 Category: Rheumatology Authors: Sina Arman Tags: COCHRANE CORNER Source Type: research
Clinicians ’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study
Bisphosphonate medications, including alendronate, ibandronate and risedronate administered orally and zoledronate, administered intravenously, are commonly prescribed for the treatment of osteoporosis based o... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - September 29, 2023 Category: Orthopaedics Authors: Simon Bishop, Melanie Jay Narayanasamy, Zoe Paskins, Nadia Corp, Anastasios Bastounis, Jill Griffin, Neil Gittoes, Jo Leonardi-Bee, Tessa Langley and Opinder Sahota Tags: Research Source Type: research
