Fracture recurrence in hip fracture with menopausal hormone therapy versus risedronate: a clinical trial
CONCLUSIONS: MHT might not differ from risedronate in the prevention of secondary fractures and death among postmenopausal women with recent hip fracture.PMID:34240673 | DOI:10.1080/13697137.2021.1915271 (Source: Climacteric)
Source: Climacteric - July 9, 2021 Category: Geriatrics Authors: C-W Park S-J Lim Y-W Moon S-H Choi M-H Shin Y-K Min B-K Yoon Y-S Park Source Type: research
Fracture recurrence in hip fracture with menopausal hormone therapy versus risedronate: a clinical trial
CONCLUSIONS: MHT might not differ from risedronate in the prevention of secondary fractures and death among postmenopausal women with recent hip fracture.PMID:34240673 | DOI:10.1080/13697137.2021.1915271 (Source: Climacteric)
Source: Climacteric - July 9, 2021 Category: Geriatrics Authors: C-W Park S-J Lim Y-W Moon S-H Choi M-H Shin Y-K Min B-K Yoon Y-S Park Source Type: research
Nebulization of Risedronate Sodium Microspheres for Potential Attenuation of Pulmonary Emphysema: a Promising New Insight of Alveolar Macrophage Apoptosis
AAPS PharmSciTech. 2021 Jul 7;22(5):202. doi: 10.1208/s12249-021-02078-8.ABSTRACTRisedronate sodium (RS) is a potent nitrogen-containing bisphosphonate which is known to induce osteoclast apoptosis. As a drug repurposing approach, the current work explored the potential of nebulizable RS-chitosan (CS) microspheres to induce alveolar macrophage apoptosis. RS-CS microspheres were assessed for lung deposition, cytotoxicity, and cellular uptake percentage in Calu-3 cells. The potential of nebulizable microspheres for treating elastase-induced emphysema in rats was investigated, compared to RS marketed oral tablets®, with resp...
Source: AAPS PharmSciTech - July 8, 2021 Category: Drugs & Pharmacology Authors: Omar A Elkady Layla M Saleh Mina Ibrahim Tadros Hanan M El-Laithy Source Type: research
Nebulization of Risedronate Sodium Microspheres for Potential Attenuation of Pulmonary Emphysema: a Promising New Insight of Alveolar Macrophage Apoptosis
AAPS PharmSciTech. 2021 Jul 7;22(5):202. doi: 10.1208/s12249-021-02078-8.ABSTRACTRisedronate sodium (RS) is a potent nitrogen-containing bisphosphonate which is known to induce osteoclast apoptosis. As a drug repurposing approach, the current work explored the potential of nebulizable RS-chitosan (CS) microspheres to induce alveolar macrophage apoptosis. RS-CS microspheres were assessed for lung deposition, cytotoxicity, and cellular uptake percentage in Calu-3 cells. The potential of nebulizable microspheres for treating elastase-induced emphysema in rats was investigated, compared to RS marketed oral tablets®, with resp...
Source: AAPS PharmSciTech - July 8, 2021 Category: Drugs & Pharmacology Authors: Omar A Elkady Layla M Saleh Mina Ibrahim Tadros Hanan M El-Laithy Source Type: research
Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites
Int J Biol Macromol. 2021 May 18:S0141-8130(21)01054-0. doi: 10.1016/j.ijbiomac.2021.05.079. Online ahead of print.ABSTRACTNano-fiber composites have shown promising potential in biomedical and biotechnological applications. Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning. Nano-fibers incorporating 10% (by wt.) of BG were uniform, dense and defect-free with a diameter of 20-125 nm. The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming ...
Source: International Journal of Biological Macromolecules - May 21, 2021 Category: Biochemistry Authors: Mohamed S El-Okaily Amira M El-Rafei Mona Basha Nour T Abdel Ghani Mayyada El-Sayed None AsimBhaumik Amany A Mostafa Source Type: research
Efficient drug delivery vehicles of environmentally benign nano-fibers comprising bioactive glass/chitosan/polyvinyl alcohol composites
Int J Biol Macromol. 2021 May 18:S0141-8130(21)01054-0. doi: 10.1016/j.ijbiomac.2021.05.079. Online ahead of print.ABSTRACTNano-fiber composites have shown promising potential in biomedical and biotechnological applications. Herein, novel nano-fiber composites constituting a blend of polyvinyl alcohol (PVA) and chitosan (CS) along with different weight ratios of nano-bioactive glass (BG) were prepared by electrospinning. Nano-fibers incorporating 10% (by wt.) of BG were uniform, dense and defect-free with a diameter of 20-125 nm. The model osteoporotic drug (Risedronate sodium) was blended with the electrospinning forming ...
Source: International Journal of Biological Macromolecules - May 21, 2021 Category: Biochemistry Authors: Mohamed S El-Okaily Amira M El-Rafei Mona Basha Nour T Abdel Ghani Mayyada El-Sayed None AsimBhaumik Amany A Mostafa Source Type: research
Bisphosphonate-related atypical insufficiency fracture of the tibial plateau : A case report
Conclusion : All clinicians need to be aware of the delayed healing of atypical insufficiency fracture related with prolonged BP use. J. Med. Invest. 68 : 186-188, February, 2021.PMID:33994468 | DOI:10.2152/jmi.68.186 (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - May 17, 2021 Category: General Medicine Authors: Ashish Suthar Kiminori Yukata Yutaka Suetomi Kazuhiro Yamazaki Takashi Sakai Hiroshi Fujii Source Type: research
