Activation of Wnt signaling mitigates blood-brain barrier disruption by inhibiting vesicular transcytosis after traumatic brain injury in mice
This study aims to elucidate the impact of Wnt/β-catenin signaling on cerebrovascular vesicular transcytosis following TBI. In this experiment, adult male wild-type (WT) C57BL/6 mice underwent various interventions. TBI was induced utilizing the controlled cortical impact technique. Post-TBI, mice were administered either an inhibitor or an agonist of Wnt signaling via intraperitoneal injection. Recombinant adeno-associated virus (rAAV) was administered intracerebroventricularly to modulate the expression of the CAV-1 inhibitory protein, Major facilitator superfamily domain-containing 2a (Mfsd2a). This research utilized E...
Source: Experimental Neurology - April 19, 2024 Category: Neurology Authors: Yuan Zhang Jianfeng Xu Pengcheng Li Bo Luo Hui Tang Source Type: research

How much or how often? Examining the screening properties of the DSM cross-cutting symptom measure in a youth population-based sample
CONCLUSIONS: The DSM-XC domains showed transdiagnostic screening properties, providing small but meaningful changes in the likelihood of internalizing disorders in the community, which can be improved by asking frequency of symptoms compared to intensity. The DSM-XC is currently lacking meaningful domains for externalizing disorders.PMID:38639338 | DOI:10.1017/S0033291724000849 (Source: Psychological Medicine)
Source: Psychological Medicine - April 19, 2024 Category: Psychiatry Authors: Jo ão Pedro Gonçalves Pacheco Christian Kieling Pedro H Manfro Ana M B Menezes Helen Gon çalves Isabel O Oliveira Fernando C Wehrmeister Luis Augusto Rohde Maur ício Scopel Hoffmann Source Type: research

Digital health –based exposure therapies for patients with posttraumatic stress disorder: A systematic review of randomized controlled trials
AbstractAlthough exposure therapies have established effects in treating posttraumatic stress disorder (PTSD), these therapies might be hindered by issues of cost, distance, time, and human resources, which are potentially alleviated by digital health. Despite the potential of digital health, there is currently no systematic review specifically evaluating digital health –based exposure therapies. We aimed to conduct a systematic literature review of randomized controlled trials (RCTs) examining the impact of digital health–based exposure therapies in treating patients with PTSD. A literature search was conducted from D...
Source: Journal of Traumatic Stress - April 19, 2024 Category: Psychiatry & Psychology Authors: Mayu Yoshikawa, Zui Narita, Yoshiharu Kim Tags: REVIEW ARTICLE Source Type: research

Posttraumatic stress disorder (PTSD) and complex PTSD in eating disorder treatment ‐seekers: Prevalence and associations with symptom severity
AbstractAlthough childhood trauma and posttraumatic stress disorder (PTSD) have been well-researched in eating disorder epidemiology, prevalence rates are unavailable for complex PTSD (CPTSD). Under recently introducedICD-11 criteria, individuals with CPTSD have both PTSD symptoms and additional disturbances in self-organization (DSO). UsingICD-11 criteria, this study aimed to determine the prevalence of PTSD and DSO symptoms, diagnostic rates of PTSD and CPTSD, and childhood trauma exposure in eating disorder treatment-seekers. Participants (N = 217) were individuals attending residential, partial hospitalization, and out...
Source: Journal of Traumatic Stress - April 19, 2024 Category: Psychiatry & Psychology Authors: Sinead Day, Phillipa Hay, Christopher Basten, Susan Byrne, Amanda Dearden, Mandy Goldstein, Amy Hannigan, Gabriella Heruc, Catherine Houlihan, Marion Roberts, W. Kathy Tannous, Chris Thornton, Natalie Valentine, Deborah Mitchison Tags: RESEARCH ARTICLE Source Type: research

Impact of veteran ‐led peer mentorship on posttraumatic stress disorder
AbstractPeer mentorship shows promise as a strategy to support veteran mental health. A community –academic partnership involving a veteran-led nonprofit organization and institutions of higher education evaluated a collaboratively developed peer mentor intervention. We assessed posttraumatic stress disorder (PTSD), postdeployment experiences, social functioning, and psychological strengths at baseline, midpoint, and 12-week discharge using the PTSD Checklist forDSM-5 (PCL-5), Deployment Risk and Resilience Inventory –2, Social Adaptation Self-evaluation Scale, and Values in Action Survey. Brief weekly check-in surveys...
Source: Journal of Traumatic Stress - April 18, 2024 Category: Psychiatry & Psychology Authors: Zeno Franco, Leslie Ruffalo, Bob Curry, Martina Gollin ‐Graves, Sheikh Iqbal Ahamed, Otis Winstead, Katinka Hooyer, Myah Pazdera, Lisa Rein, Jose Lizarraga Mazaba, Md Fitrat Hossain, Virginia Stoffel, Mark Flower, Praveen Madiraju, Stephen Tags: RESEARCH ARTICLE Source Type: research

Beyond exposure: A healthy broadening of posttraumatic stress disorder treatment options: Commentary on Rubenstein et al. (2024)
Am Psychol. 2024 Apr;79(3):347-349. doi: 10.1037/amp0001233.ABSTRACTThis commentary on Rubenstein et al. (2024) applauds their sensitive historical exploration of exposure therapy for posttraumatic stress disorder (PTSD) and balanced review of the strengths and weaknesses of that approach. I offer five points to expand on their contribution. (a) Stringent exposure therapy workforce requirements limit scalability, thus restricting access for the large number of patients in need of PTSD treatment. (b) There are additional non-trauma-focused approaches that show efficacy for PTSD. (c) Results of exposure therapy trials should...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Lisa M Najavits Source Type: research

To expose or not to expose: A comprehensive perspective on treatment for posttraumatic stress disorder
Am Psychol. 2024 Apr;79(3):331-343. doi: 10.1037/amp0001121.ABSTRACTTrauma-focused psychotherapies, in particular prolonged exposure (PE) therapy, have been recognized as the "gold standard" for the treatment of posttraumatic stress disorder (PTSD). But effectiveness and implementation data show that a large proportion of patients who undergo exposure therapy retain their PTSD diagnosis, and implementation studies have shown low engagement and high dropout rates. Meanwhile, non-trauma-focused therapies have shown promise in treating PTSD. In this review, we aim to answer the question of whether exposure is necessary to tre...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Arielle Rubenstein Or Duek Jennifer Doran Ilan Harpaz-Rotem Source Type: research

Storylines of Trauma in Health Professions Education: A Critical Metanarrative Review
Teach Learn Med. 2024 Apr 18:1-13. doi: 10.1080/10401334.2024.2342443. Online ahead of print.ABSTRACTPHENOMENON: Learners in medical education are often exposed to content and situations that might be experienced as traumatic, which in turn has both professional and personal implications. The purpose of this study was to synthesize the literature on how trauma has been conceptualized and approached within medical education, and the implications thereof.APPROACH: A metanarrative approach was adopted following the RAMESES guidelines. Searches of 7 databases conducted in January 2022 with no date limitations yielded 7,280 art...
Source: Teaching and Learning in Medicine - April 18, 2024 Category: Universities & Medical Training Authors: Amanda L Roze des Ordons Rachel H Ellaway Source Type: research

PERSPECTIVE: A Path to Value-Based Insurance Design for Mental Health Services
DISCUSSION: The inability to afford mental health care is a top barrier to treatment seeking. People who do elect to spend time and money on mental health care are further disadvantaged by accessing care that is not well regulated and the quality at best is questionable. VBID could be an important lever for increasing access to and use of high value mental health care. Partnerships among the research, practice, and policy communities can help ensure research solutions meet needs of these two communities.IMPLICATIONS FOR HEALTH CARE: VBID holds promise to make high value mental health care more affordable while discouraging...
Source: Journal of Mental Health Policy and Economics - April 18, 2024 Category: Psychiatry Authors: Michael C Freed Jennifer L Humensky Patricia A Arean Source Type: research

Factors associated with self-awareness impairment in an inpatient brain injury rehabilitation cohort
CONCLUSION: Different factors were associated with impaired self-awareness for individuals with TBI and stroke during inpatient rehabilitation.PMID:38634476 | DOI:10.1080/02699052.2024.2344096 (Source: Brain Injury)
Source: Brain Injury - April 18, 2024 Category: Neurology Authors: Danielle Sansonetti Jennifer Fleming Freyr Patterson Laura De Lacy Natasha A Lannin Source Type: research

When Imagination Feels Like Reality: A Case Study of False Memories and Maladaptive Daydreaming in Visual Impairment
CONCLUSION: This first reported case of confabulations in an individual with MD and visual disability suggests daydreams could potentially be mistaken for actual events in some MD cases. While sensitive, more research is needed on the prevalence of false memories among individuals with MD. The default mode network, prefrontal cortex, and their connectivity may be implicated in generating vivid daydreams and misattributing them to actual episodic events. Understanding the relationship between sensory impairments, dissociation, and susceptibility to memory distortions could inform interventions to improve reality testing for...
Source: Case Reports in Psychiatry - April 18, 2024 Category: Psychiatry Authors: Eli Somer Source Type: research

Storylines of Trauma in Health Professions Education: A Critical Metanarrative Review
Teach Learn Med. 2024 Apr 18:1-13. doi: 10.1080/10401334.2024.2342443. Online ahead of print.ABSTRACTPHENOMENON: Learners in medical education are often exposed to content and situations that might be experienced as traumatic, which in turn has both professional and personal implications. The purpose of this study was to synthesize the literature on how trauma has been conceptualized and approached within medical education, and the implications thereof.APPROACH: A metanarrative approach was adopted following the RAMESES guidelines. Searches of 7 databases conducted in January 2022 with no date limitations yielded 7,280 art...
Source: Teaching and Learning in Medicine - April 18, 2024 Category: Universities & Medical Training Authors: Amanda L Roze des Ordons Rachel H Ellaway Source Type: research

Beyond exposure: A healthy broadening of posttraumatic stress disorder treatment options: Commentary on Rubenstein et al. (2024)
Am Psychol. 2024 Apr;79(3):347-349. doi: 10.1037/amp0001233.ABSTRACTThis commentary on Rubenstein et al. (2024) applauds their sensitive historical exploration of exposure therapy for posttraumatic stress disorder (PTSD) and balanced review of the strengths and weaknesses of that approach. I offer five points to expand on their contribution. (a) Stringent exposure therapy workforce requirements limit scalability, thus restricting access for the large number of patients in need of PTSD treatment. (b) There are additional non-trauma-focused approaches that show efficacy for PTSD. (c) Results of exposure therapy trials should...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Lisa M Najavits Source Type: research

To expose or not to expose: A comprehensive perspective on treatment for posttraumatic stress disorder
Am Psychol. 2024 Apr;79(3):331-343. doi: 10.1037/amp0001121.ABSTRACTTrauma-focused psychotherapies, in particular prolonged exposure (PE) therapy, have been recognized as the "gold standard" for the treatment of posttraumatic stress disorder (PTSD). But effectiveness and implementation data show that a large proportion of patients who undergo exposure therapy retain their PTSD diagnosis, and implementation studies have shown low engagement and high dropout rates. Meanwhile, non-trauma-focused therapies have shown promise in treating PTSD. In this review, we aim to answer the question of whether exposure is necessary to tre...
Source: The American Psychologist - April 18, 2024 Category: Psychiatry & Psychology Authors: Arielle Rubenstein Or Duek Jennifer Doran Ilan Harpaz-Rotem Source Type: research

The prevalence and correlates of PTSD, insomnia, and fatigue among people with epilepsy during Oct.7th war on Gaza: A study from Jordan
Epilepsy Behav. 2024 Apr 17;155:109768. doi: 10.1016/j.yebeh.2024.109768. Online ahead of print.ABSTRACTJordan and Palestine are tightly related countries as the same families live in the two adjacent countries. The present study sought to examine the prevalence and determinants of Post-Traumatic Stress Disorder (PTSD)symptoms, insomnia, and fatigue among a cohort of People with Epilepsy (PWE) in Jordan. This is a cross-sectional study with inclusion criteria. PTSD, insomnia, and fatigue were assessed using validated scales. Data were analyzed from 109 PWE, PTSD symptoms were screened in (35.5 %), and Insomnia was screened...
Source: Epilepsy and Behaviour - April 18, 2024 Category: Neurology Authors: Omar Gammoh Wail Ennab Source Type: research