Spirituality/Religion Among First Responders With and Without Posttraumatic Stress Disorder and Alcohol Misuse
Conclusions: Findings highlight the high rates of independent and co-occurring alcohol misuse and PTSD among first responders as well as the salience of S/R in this population.PMID:38560884 | DOI:10.1080/15504263.2024.2330619 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - April 1, 2024 Category: Addiction Authors: Caroline C Kaufman R Kathryn McHugh Mia Drury Julia G Merrill David H Rosmarin Source Type: research

Developments in targeting calcitonin gene-related peptide
Expert Rev Neurother. 2024 Apr 1:1-9. doi: 10.1080/14737175.2024.2332754. Online ahead of print.ABSTRACTINTRODUCTION: Calcitonin Gene-Related Peptide (CGRP)-targeted therapy has revolutionized migraine treatment since its first approval in 2018. CGRP-targeted therapy includes monoclonal antibodies (mAbs) and gepants, which modulate trigeminal nociceptive and inflammatory responses, alleviating pain sensitization involved in migraine pathogenesis. CGRP-targeted therapy is effective not only for migraine but also for other chronic headache disorders that share the CGRP pathway.AREAS COVERED: The authors review the latest dev...
Source: Expert Review of Neurotherapeutics - April 1, 2024 Category: Neurology Authors: Sawsan Alabbad Nathalia Figueredo Hsiangkuo Yuan Stephen Silberstein Source Type: research

The Role of Social Support in Perinatal Mental Health and Psychosocial Stimulation
Yale J Biol Med. 2024 Mar 29;97(1):3-16. doi: 10.59249/WMGE9032. eCollection 2024 Mar.ABSTRACTSocial support refers to the help someone receives emotionally or instrumentally from their social network. Poor social support in the perinatal period has been associated with increased risk for symptoms of common mental disorders, including depression and posttraumatic stress symptoms (PTS), which may impact parenting behavior. Whether social support impacts parenting behaviors, independent of mental health symptomatology, remains unclear. Among N=309 participants of the Scaling Up Maternal Mental healthcare by Increasing access...
Source: The Yale Journal of Biology and Medicine - April 1, 2024 Category: Universities & Medical Training Authors: Tatjana L Kay Margaret C Moulson Simone N Vigod Nour Schoueri-Mychasiw Daisy R Singla Source Type: research

Developments in targeting calcitonin gene-related peptide
Expert Rev Neurother. 2024 Apr 1:1-9. doi: 10.1080/14737175.2024.2332754. Online ahead of print.ABSTRACTINTRODUCTION: Calcitonin Gene-Related Peptide (CGRP)-targeted therapy has revolutionized migraine treatment since its first approval in 2018. CGRP-targeted therapy includes monoclonal antibodies (mAbs) and gepants, which modulate trigeminal nociceptive and inflammatory responses, alleviating pain sensitization involved in migraine pathogenesis. CGRP-targeted therapy is effective not only for migraine but also for other chronic headache disorders that share the CGRP pathway.AREAS COVERED: The authors review the latest dev...
Source: Expert Review of Neurotherapeutics - April 1, 2024 Category: Neurology Authors: Sawsan Alabbad Nathalia Figueredo Hsiangkuo Yuan Stephen Silberstein Source Type: research

Spirituality/Religion Among First Responders With and Without Posttraumatic Stress Disorder and Alcohol Misuse
Conclusions: Findings highlight the high rates of independent and co-occurring alcohol misuse and PTSD among first responders as well as the salience of S/R in this population.PMID:38560884 | DOI:10.1080/15504263.2024.2330619 (Source: Journal of Dual Diagnosis)
Source: Journal of Dual Diagnosis - April 1, 2024 Category: Addiction Authors: Caroline C Kaufman R Kathryn McHugh Mia Drury Julia G Merrill David H Rosmarin Source Type: research

The Role of Social Support in Perinatal Mental Health and Psychosocial Stimulation
Yale J Biol Med. 2024 Mar 29;97(1):3-16. doi: 10.59249/WMGE9032. eCollection 2024 Mar.ABSTRACTSocial support refers to the help someone receives emotionally or instrumentally from their social network. Poor social support in the perinatal period has been associated with increased risk for symptoms of common mental disorders, including depression and posttraumatic stress symptoms (PTS), which may impact parenting behavior. Whether social support impacts parenting behaviors, independent of mental health symptomatology, remains unclear. Among N=309 participants of the Scaling Up Maternal Mental healthcare by Increasing access...
Source: The Yale Journal of Biology and Medicine - April 1, 2024 Category: Universities & Medical Training Authors: Tatjana L Kay Margaret C Moulson Simone N Vigod Nour Schoueri-Mychasiw Daisy R Singla Source Type: research

Developments in targeting calcitonin gene-related peptide
Expert Rev Neurother. 2024 Apr 1:1-9. doi: 10.1080/14737175.2024.2332754. Online ahead of print.ABSTRACTINTRODUCTION: Calcitonin Gene-Related Peptide (CGRP)-targeted therapy has revolutionized migraine treatment since its first approval in 2018. CGRP-targeted therapy includes monoclonal antibodies (mAbs) and gepants, which modulate trigeminal nociceptive and inflammatory responses, alleviating pain sensitization involved in migraine pathogenesis. CGRP-targeted therapy is effective not only for migraine but also for other chronic headache disorders that share the CGRP pathway.AREAS COVERED: The authors review the latest dev...
Source: Expert Review of Neurotherapeutics - April 1, 2024 Category: Neurology Authors: Sawsan Alabbad Nathalia Figueredo Hsiangkuo Yuan Stephen Silberstein Source Type: research

Post-traumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: Secondary analysis of a randomized controlled trial
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - April 1, 2024 Category: Rheumatology Authors: Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group Tags: Clinical Trial Source Type: research

Surgical Rodent Model of Osteoarthritis Alters Joint Structure, Tactile Sensitivity, and the Brain
Osteoarthritis (OA) is a debilitating and painful joint disorder with a significant impact on patient ’s lives. However, the effects of OA on pain-processing regions in the brain are poorly understood. To address this gap, the current study investigates joint remodeling, pain-related behavior, and brain remodeling in a surgical rodent model of post-traumatic osteoarthritis. Male and female Fischer -344 rats (18-19 months) received either a skin-incision (n=6 male, n=10 female) or medial meniscus transection plus medial collateral ligament transection (MMT+MCLT) (n=5 male, n=11 female) surgery. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Jacob L. Griffith, Pedro Valdes Hernandez, Yenisel Cruz-Almeida, Marcelo Febo, Kyle D. Allen Source Type: research

Adverse Childhood Experiences, Posttraumatic Stress Disorder, and Symptom Severity Among Patients with Autonomic Disorders and Overlapping Chronic Pain Conditions
We examined whether adverse childhood experiences (ACEs) or current posttraumatic stress disorder (PTSD) predicted symptom severity and quality of life in patients with autonomic disorders like postural tachycardia syndrome (POTS) and associated chronic overlapping pain conditions. Although it is known that trauma exposure and PTSD are associated with persistent sympathetic arousal, little work has examined this relationship in patients with chronic autonomic health conditions. We hypothesized that ACEs and PTSD would be associated with worse autonomic clinical outcomes. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Taylor Crouch, Mary Wells, Madison Maxwell, Tom Chelimsky Source Type: research

Emotional Support, Post-Traumatic Stress Disorder and Risk for Long-Term, High-Dose, Daily Prescription Opioid Use
Post-traumatic stress disorder (PTSD) is common in patients with chronic pain, adversely affects chronic pain outcomes, and is associated with opioid use and adverse opioid outcomes. Social support is a robust predictor of PTSD incidence and course as well as chronic pain outcome. We determined whether the association between PTSD and persistent opioid use was modified by emotional support in a cohort of patients receiving opioids for non-cancer pain. Eligible participants were ≥ 18, and had completed a new period of prescription opioid use lasting 30-90 days Bivariate association between cohort characteristics and each ...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Mark Sullivan, Lauren Wilson, Matthew Amick, Lisa Miller-Matero, Timothy Chrusciel, Joanne Salas, Celeste Zabel, Patrick Lustman, Brian Ahmedani, Ryan Carpenter, Jeffrey Scherrer Source Type: research