"It's not only the injury but also the kind of head." Factors influencing outcome after traumatic brain injury
CONCLUSIONS: Alongside consideration of injury severity, consideration of pre-injury factors is important to inform prognostication and rehabilitation planning.PMID:38493908 | DOI:10.1016/j.apmr.2024.03.003 (Source: Health Physics)
Source: Health Physics - March 17, 2024 Category: Physics Authors: Jennie L Ponsford Meagan Carty John Olver Michael Ponsford Rose Acher Dean McKenzie Marina G Downing Source Type: research

The Prevalence of Post-traumatic Stress Disorder as Part of Post-ICU Syndrome among Israeli ICU Survivors
CONCLUSIONS: We found lower incidence of PTSD in our cohort when compared to existing literature. Possible explanations include different diagnostic tools and low risk factors rate. Unique national, cultural, and/or religious perspectives might have contributed to the observed low PTSD rate. Further research in larger study populations is required to establish the prevalence of PTSD among Israeli ICU survivors.PMID:38493331 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - March 17, 2024 Category: General Medicine Authors: Shiri Zarour Esther Dahan Dana Karol Or Hanoch Barak Cohen Idit Matot Source Type: research

CK2 negatively regulates the extinction of remote fear memory
In this study, we adopted a classical Pavlovian fear conditioning model to investigate the involvement of CK2 in remote fear memory extinction and its underlying mechanisms. The results indicated that the activity of CK2 in the medial prefrontal cortex (mPFC) of mice was significantly upregulated after extinction training of remote cued fear memory. Notably, administration of the CK2 inhibitor CX-4945 prior to extinction training facilitated the extinction of remote fear memory. In addition, CX-4945 significantly upregulated the expression of p-ERK1/2 and p-CREB in the mPFC. Our results suggest that CK2 negatively regulate...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Jie Yang Lin Lin Guang-Jing Zou Lai-Fa Wang Fang Li Chang-Qi Li Yan-Hui Cui Fu-Lian Huang Source Type: research

CK2 negatively regulates the extinction of remote fear memory
In this study, we adopted a classical Pavlovian fear conditioning model to investigate the involvement of CK2 in remote fear memory extinction and its underlying mechanisms. The results indicated that the activity of CK2 in the medial prefrontal cortex (mPFC) of mice was significantly upregulated after extinction training of remote cued fear memory. Notably, administration of the CK2 inhibitor CX-4945 prior to extinction training facilitated the extinction of remote fear memory. In addition, CX-4945 significantly upregulated the expression of p-ERK1/2 and p-CREB in the mPFC. Our results suggest that CK2 negatively regulate...
Source: Behavioural Brain Research - March 17, 2024 Category: Neurology Authors: Jie Yang Lin Lin Guang-Jing Zou Lai-Fa Wang Fang Li Chang-Qi Li Yan-Hui Cui Fu-Lian Huang Source Type: research

What Predicts COVID-Specific Symptoms of Stress in Children and Adolescents, Virus Threats or Social Distancing?
AbstractThe COVID-19 crisis may have deleterious effects on children ’s and adolescents’ mental health. However, there have been no published studies in which the COVID-related stress symptoms were investigated in a French ordinary pediatric population. The main objective of this study was to examine virus threats and social distancing measures to determine which were more disturbing for children and adolescents, and which were better predictors of post traumatic stress symptoms (PTSS). 1639 parents of children aged between 1 and 18 participated in an online survey. Parents completed questionnaires regarding their chil...
Source: Journal of Child and Adolescent Trauma - March 16, 2024 Category: Child Development Source Type: research

A unique combination of horror and longing: Traumatic grief in post –October 7, 2023, Israel
AbstractOn October 7, 2023 (10/7), Hamas militants brutally attacked Israeli towns and villages surrounding the Gaza Strip, resulting in the killing of more than 1100 people, most of whom were civilians slaughtered in their own homes. The killings occurred under highly traumatic circumstances, including shooting, the burning of homes, hunting down people who attempted to escape, and severe sexual assault. Thus, many Israelis today experience a unique mix of both posttraumatic and severe grief reactions. Traumatic grief (TG) is often defined as a condition that results from the death of a significant other and includes symp...
Source: Journal of Traumatic Stress - March 15, 2024 Category: Psychiatry & Psychology Authors: Ilanit Hasson ‐Ohayon, Danny Horesh Tags: COMMENTARY Source Type: research

Multiple trauma exposure and psychopathology in Syrian refugees living in Turkey: A latent class analysis
DISCUSSION: The latent classes identified in this study correspond with previous research regarding trauma in Syrian refugees. However, this study largely failed to find significant differences in mental health diagnoses between classes. Future research should consider the effect of post-migration stressors in refugee populations, which may play a crucial role in mental health outcomes.PMID:38490133 | DOI:10.1016/j.actpsy.2024.104220 (Source: Acta Psychologica)
Source: Acta Psychologica - March 15, 2024 Category: Psychiatry & Psychology Authors: Caitlyn Rawers Enya Redican Emre Han Alpay Eoin McElroy Mark Shevlin Source Type: research

Investigating the dissociative subtype of post-traumatic stress disorder in single- and multi-event trauma-exposed youth: Prevalence, course, prognosis, severity and functional impairment
CONCLUSIONS: These results should be viewed in the context of several limitations including narrow sample of participants which reduces the generalizability of results, concerns around children's ability to conceptualize challenging concepts such as dissociation and the use of self-report measures to form diagnostic groups. The PTSD-DS diagnosis may offer clinical utility to the extant PTSD diagnosis in children and adolescents, as dissociation has been shown to be a contributory factor in the maintenance of both PTSS and functional impairment. Further research is required to inform further editions of the DSM and other di...
Source: The British Journal of Clinical Psychology - March 15, 2024 Category: Psychiatry & Psychology Authors: William F White Aaron Burgess Tim Dalgleish Clare Dixon Sarah L Halligan Rachel M Hiller Anna McKinnon Patrick Smith Richard Meiser-Stedman Source Type: research

Multiple trauma exposure and psychopathology in Syrian refugees living in Turkey: A latent class analysis
DISCUSSION: The latent classes identified in this study correspond with previous research regarding trauma in Syrian refugees. However, this study largely failed to find significant differences in mental health diagnoses between classes. Future research should consider the effect of post-migration stressors in refugee populations, which may play a crucial role in mental health outcomes.PMID:38490133 | DOI:10.1016/j.actpsy.2024.104220 (Source: Acta Psychologica)
Source: Acta Psychologica - March 15, 2024 Category: Psychiatry & Psychology Authors: Caitlyn Rawers Enya Redican Emre Han Alpay Eoin McElroy Mark Shevlin Source Type: research

Investigating the dissociative subtype of post-traumatic stress disorder in single- and multi-event trauma-exposed youth: Prevalence, course, prognosis, severity and functional impairment
CONCLUSIONS: These results should be viewed in the context of several limitations including narrow sample of participants which reduces the generalizability of results, concerns around children's ability to conceptualize challenging concepts such as dissociation and the use of self-report measures to form diagnostic groups. The PTSD-DS diagnosis may offer clinical utility to the extant PTSD diagnosis in children and adolescents, as dissociation has been shown to be a contributory factor in the maintenance of both PTSS and functional impairment. Further research is required to inform further editions of the DSM and other di...
Source: The British Journal of Clinical Psychology - March 15, 2024 Category: Psychiatry & Psychology Authors: William F White Aaron Burgess Tim Dalgleish Clare Dixon Sarah L Halligan Rachel M Hiller Anna McKinnon Patrick Smith Richard Meiser-Stedman Source Type: research

Connecting cellular mechanisms and extracellular vesicle cargo in traumatic brain injury
Neural Regen Res. 2024 Oct 1;19(10):2119-2131. doi: 10.4103/1673-5374.391329. Epub 2023 Dec 21.ABSTRACTTraumatic brain injury is followed by a cascade of dynamic and complex events occurring at the cellular level. These events include: diffuse axonal injury, neuronal cell death, blood-brain barrier break down, glial activation and neuroinflammation, edema, ischemia, vascular injury, energy failure, and peripheral immune cell infiltration. The timing of these events post injury has been linked to injury severity and functional outcome. Extracellular vesicles are membrane bound secretory vesicles that contain markers and car...
Source: Cell Research - March 15, 2024 Category: Cytology Authors: Nikita Ollen-Bittle Austyn D Roseborough Wenxuan Wang Jeng-Liang D Wu Shawn N Whitehead Source Type: research

Investigating the dissociative subtype of post-traumatic stress disorder in single- and multi-event trauma-exposed youth: Prevalence, course, prognosis, severity and functional impairment
CONCLUSIONS: These results should be viewed in the context of several limitations including narrow sample of participants which reduces the generalizability of results, concerns around children's ability to conceptualize challenging concepts such as dissociation and the use of self-report measures to form diagnostic groups. The PTSD-DS diagnosis may offer clinical utility to the extant PTSD diagnosis in children and adolescents, as dissociation has been shown to be a contributory factor in the maintenance of both PTSS and functional impairment. Further research is required to inform further editions of the DSM and other di...
Source: The British Journal of Clinical Psychology - March 15, 2024 Category: Psychiatry & Psychology Authors: William F White Aaron Burgess Tim Dalgleish Clare Dixon Sarah L Halligan Rachel M Hiller Anna McKinnon Patrick Smith Richard Meiser-Stedman Source Type: research

Posttraumatic Stress Disorder 2 Months After Cesarean Delivery: a Multicenter Prospective Study
The prevalence and risk factors of posttraumatic stress disorder (PTSD) after cesarean delivery, outside high-risk contexts, remain unclear (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - March 15, 2024 Category: OBGYN Authors: Aliz ée FROELIGER, Catherine DENEUX-THARAUX, Lola LOUSSERT, Hugo MADAR, Loïc SENTILHES, Tranexamic Acid for Preventing Postpartum Hemorrhage after Cesarean Delivery (TRAAP2) trial study group Tags: Original Research: Obstetrics Source Type: research

A Comparison of the Psychometric Properties of a Person-Administered vs. Automated Screening Tool for Posttraumatic Stress Disorder (PTSD) in Traumatically Injured Patients
Poor mental health outcomes, including posttraumatic stress disorder (PTSD), affect greater than 20% of trauma patients 12 months post-injury.[1,2] PTSD after traumatic injury is associated with poor physical recovery, social functioning, and quality of life.[3,4] Despite the known effects that adverse mental health outcomes have on trauma patient recovery, only a small portion of trauma centers have protocols in place to address PTSD.[5] For these reasons, the American College of Surgeons Committee on Trauma (ACS-CoT) has required that trauma centers have mental health screening and referral protocols in place by 2023. (Source: Injury)
Source: Injury - March 15, 2024 Category: Orthopaedics Authors: Amber Brandolino, Elise A. Biesboer, Morgan Leissring, Rachel Weber, Sydney Timmer-Murillo, Terri A. deRoon-Cassini, Mary E. Schroeder Source Type: research

Correlates of post-traumatic growth among persons bereaved from cancer: A systematic review and meta-analysis
ConclusionsVery few studies examined PTG among persons bereaved from cancer, highlighting the need for increased attention, understanding, and conceptualisation of PTG in the population. (Source: PLoS One)
Source: PLoS One - March 15, 2024 Category: Biomedical Science Authors: N. V. Sri Lakshmi K. Source Type: research