Post-traumatic stress disorder in doctors: Origins, approach and Eye Movement Desensitisation and Reprocessing therapy
CONCLUSION: Doctors have higher prevalence rates of ATSS and PTSD than the general public. Eye Movement Desensitisation and Reprocessing therapy's early-intervention protocols for recent, prolonged and ongoing traumatic stress have the potential to be a widely acceptable, timely and cost-effective intervention for doctors and other healthcare workers (HCWs), as highlighted in the emerging evidence base, which has grown considerably in response to the impact of the COVID pandemic on HCWs' mental health. These evidence-based interventions could potentially be routinely offered to doctors and other HCWs within 1 month of an a...
Source: Australasian Psychiatry - March 23, 2023 Category: Psychiatry Authors: Kelvin Cy Leung Catherine McCarthy Loyola McLean Source Type: research

Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma
CONCLUSIONS: Our findings shed new light on the relation between biological aging and trauma-related phenotypes, suggesting that GrimAge measured at the time of trauma predicts PTSD trajectories and is associated with relevant brain alterations. Furthering these findings has the potential to enhance early prevention and treatment of posttraumatic psychiatric sequelae.PMID:36951141 | DOI:10.1017/S0033291723000636 (Source: Psychological Medicine)
Source: Psychological Medicine - March 23, 2023 Category: Psychiatry Authors: Anthony S Zannas Sarah D Linnstaedt Xinming An Jennifer S Stevens Nathaniel G Harnett Alyssa R Roeckner Katelyn I Oliver David R Rubinow Elisabeth B Binder Karestan C Koenen Kerry J Ressler Samuel A McLean Source Type: research

Treatment of posttraumatic stress symptoms with EMDR in a patient with aphasia
Tijdschr Psychiatr. 2023;65(3):186-189.ABSTRACTPOSTTRAUMATIC STRESS DISORDER (PTSD) IS HIGHLY PREVALENT IN PATIENTS WITH ACQUIRED BRAIN INJURY. EYE MOVEMENT DESENSITIZATION AND REPROCESSING (EMDR) IS AN EFFECTIVE TREATMENT FOR POSTTRAUMATIC STRESS SYMPTOMS. HOWEVER, SCIENTIFIC RESEARCH ON APPLICABILITY AND EFFECTIVENESS OF EMDR IN ACQUIRED BRAIN INJURY, AND MORE SPECIFICALLY IN PATIENTS WITH APHASIA, IS SCARCE. WE DESCRIBE THE TREATMENT OF POSTTRAUMATIC STRESS SYMPTOMS WITH EMDR IN A PATIENT WITH APHASIA AFTER ACQUIRED BRAIN INJURY. WE ADJUSTED EMDR STANDARD PROTOCOL. THERAPY WAS RELATIVELY SHORT, THE SPOUSE WAS INVOLVED I...
Source: Tijdschrift voor Psychiatrie - March 23, 2023 Category: Psychiatry Authors: E P J Janssen L van Donzel Source Type: research

C-Reactive Protein (CRP): A Potent Inflammation Biomarker in Psychiatric Disorders
Adv Exp Med Biol. 2023;1411:135-160. doi: 10.1007/978-981-19-7376-5_7.ABSTRACTAn increasing number of studies have investigated the role of inflammation in psychiatric disorders, by demonstrating how an altered/dysfunctional immunological and inflammatory system may underpin a psychiatric condition. Particularly, several studies specifically investigated the role of a neuroinflammatory biomarker, named C-reactive protein (CRP), in psychiatric disorders. Overall, even though scientific literature so far published still does not appear definitive, CRP is more likely reported to be elevated in several psychiatric disorders, i...
Source: Advances in Experimental Medicine and Biology - March 23, 2023 Category: Research Authors: Laura Orsolini Simone Pompili Umberto Volpe Source Type: research

PTSD, Immune System, and Inflammation
Adv Exp Med Biol. 2023;1411:225-262. doi: 10.1007/978-981-19-7376-5_11.ABSTRACTPosttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially cardiovascular and metabolic disorders, and with chronic low-grade inflammation. Altered balance of the hypothalamic-pituitary-adrenal (HPA) axis, cytokines and chemokines, C-reactive protein, oxidative stress markers, kynurenine pathways, and gut microbiota might be involved in the alterations of certain brain regions regulating fear conditioning and memory processes, that are all altered in PTSD. In ad...
Source: Advances in Experimental Medicine and Biology - March 23, 2023 Category: Research Authors: Nela Pivac Barbara Vuic Marina Sagud Gordana Nedic Erjavec Matea Nikolac Perkovic Marcela Konjevod Lucija Tudor Dubravka Svob Strac Suzana Uzun Oliver Kozumplik Sandra Uzun Ninoslav Mimica Source Type: research

The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders
Adv Exp Med Biol. 2023;1411:513-535. doi: 10.1007/978-981-19-7376-5_22.ABSTRACTPeroxisome proliferator-activated receptors (PPARs) are nonsteroid nuclear receptors and transcription factors that regulate several neuroinflammatory and metabolic processes, recently involved in several neuropsychiatric conditions, including Alzheimer's disease, Parkinson's disease, major depressive disorder, post-traumatic stress disorder (PTSD), schizophrenia spectrum disorders, and autism spectrum disorders. PPARs are ligand-activated receptors that, following stimulation, induce neuroprotective effects by decreasing neuroinflammatory proce...
Source: Advances in Experimental Medicine and Biology - March 23, 2023 Category: Research Authors: Francesco Matrisciano Graziano Pinna Source Type: research

Child Traumatic Stress and COVID-19: The Impact of the Pandemic on a Clinical Sample of Children in Trauma Treatment
AbstractGiven the scope and duration of the COVID-19 pandemic, it is not surprising that research has documented negative effects to youth ’s mental health. Yet, there is negligible research on the impact of the pandemic among clinical samples of youth receiving treatment for pre-existing trauma exposure and symptoms. The current study investigates COVID-19 as an index trauma, and if prior traumatic stress scores mediate the relation ship between pandemic-related exposure and subsequent traumatic stress. Methods: This is a study of 130 youth ages 7–18 receiving trauma treatment at an academic medical center. The Univer...
Source: Journal of Child and Adolescent Trauma - March 23, 2023 Category: Child Development Source Type: research

Depression, anxiety, stress, and PTSD symptoms during the first and second COVID-19 waves: a comparison of elderly, middle-aged, and young people in Iran
A widespread outbreak of epidemics like Covid-19 is a lethal threat to physical and mental health. Recent studies reported a higher prevalence of mental problems in younger individuals, contrary to the general... (Source: BMC Psychiatry)
Source: BMC Psychiatry - March 23, 2023 Category: Psychiatry Authors: Hajar Pasha, Shabnam Omidvar, Mahbobeh Faramarzi and Afsaneh Bakhtiari Tags: Research Source Type: research

Evaluation of the relationship between theory of mind relating to cognitive performance and post-traumatic stress disorder in Syrian refugee amputees living in Turkey
ConclusionsLower education level, prosthesis use for a shorter period, and poor mind-reading skills from neutral and total eye expressions were predictive of the potential presence of PTSD in amputees, even though they were largely exposed to similar traumas. Our findings suggest that treatment and follow-up of PTSD should also target deficits in cognitive and emotional abilities. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2023 Category: General Medicine Source Type: research

Mental health trajectories of Brazilian health workers during two waves of the COVID-19 pandemic (2020 –2021)
This study aimed to: (a) monitor the progression of symptoms of mental health burden among frontline workers caring for COVID-19 patients in Brazil during the two waves of the pandemic, considering the number of new cases and deaths, and; (b) to verify the different mental health outcomes and potential associations with current burnout symptoms. A non-probabilistic sample of health professionals was assessed as the pandemic progressed in Brazil (May/2020 August/2021). Standardized instruments focusing on anxiety, depression, insomnia, post-traumatic stress, and burnout symptoms were applied online. The results indicate a d...
Source: Frontiers in Psychiatry - March 23, 2023 Category: Psychiatry Source Type: research

Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD
Cogn Affect Behav Neurosci. 2023 Mar 22. doi: 10.3758/s13415-023-01077-5. Online ahead of print.ABSTRACTFew individuals who experience trauma develop posttraumatic stress disorder (PTSD). Therefore, the identification of individual differences that signal increased risk for PTSD is important. Lissek et al. (2006) proposed using a weak rather than a strong situation to identify individual differences. A weak situation involves less-salient cues as well as some degree of uncertainty, which reveal individual differences. A strong situation involves salient cues with little uncertainty, which produce consistently strong respon...
Source: Cognitive, Affective and Behavioral Neuroscience - March 22, 2023 Category: Neuroscience Authors: M Todd Allen Source Type: research

Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants
CONCLUSIONS: Our findings showed that child maltreatment is associated with shorter telomere length in middle- and older-aged adults, independent of sociodemographic and mental health factors.PMID:36946056 | DOI:10.1192/bjp.2023.33 (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - March 22, 2023 Category: Psychiatry Authors: Ziyi Zhou Camilla K M Lo Ko Ling Chan Rachel S Y Chung Jill P Pell Helen Minnis Paul G Shiels Patrick Ip Frederick K Ho Source Type: research

Stress in Post-traumatic Stress Disorder as an Incremental Mediator of Autoimmunity
Isr Med Assoc J. 2023 Mar;25(3):237-241.NO ABSTRACTPMID:36946673 (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - March 22, 2023 Category: General Medicine Authors: Dana Arnheim Arad Dotan Netta Shoenfeld Yehuda Shoenfeld Source Type: research

Virtual reality interventions for the treatment of anxiety disorders: A scoping review
CONCLUSION: VR interventions appeared to be a viable alternative to conventional exposure therapy. Future research should include more male participants and have a stronger emphasis on acceptability and side effects. Increased traction for VR interventions for generalized anxiety disorder and panic disorder is also important.PMID:36947972 | DOI:10.1016/j.jbtep.2023.101851 (Source: Behavior Therapy)
Source: Behavior Therapy - March 22, 2023 Category: Psychiatry & Psychology Authors: Nicole J Andersen Deborah Schwartzman Carolina Martinez Gina Cormier Martin Drapeau Source Type: research

The sovereignty of the visible: how traumatic memory becomes traumatic stress
Cad Saude Publica. 2023 Mar 13;39(2):e00132622. doi: 10.1590/0102-311XPT132622. eCollection 2023.ABSTRACTSince the release of the third version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III), biological psychiatry has been systematically applying its classification reasoning to social phenomena of many natures. From this perspective, the discourse of trauma gained relevance and events of devastating magnitude began to receive neurobehavioral interpretations until finally being recognized less for their cultural and subjective effects than for the physiological changes they cause. By a narrative revi...
Source: Cadernos de Saude Publica - March 22, 2023 Category: International Medicine & Public Health Authors: Ramon Reis Dos Santos Ferreira Francisco Ortega Source Type: research