Transcriptomic profiling of polycystic kidney disease identifies paracrine factors in the early cyst microenvironment
Biochim Biophys Acta Mol Basis Dis. 2023 Dec 7:166987. doi: 10.1016/j.bbadis.2023.166987. Online ahead of print.ABSTRACTInitial cysts that are formed upon Pkd1 loss in mice impose persistent stress on surrounding tissue and trigger a cystic snowball effect, in which local aberrant PKD-related signaling increases the likelihood of new cyst formation, ultimately leading to accelerated disease progression. Although many pathways have been associated with PKD progression, the knowledge of early changes near initial cysts is limited. To perform an unbiased analysis of transcriptomic alterations in the cyst microenvironment, mic...
Source: Biochimica et Biophysica Acta - December 9, 2023 Category: Biochemistry Authors: Sevtap A Yasinoglu Thomas B Kuipers Ernst Suidgeest Louise van der Weerd Hailiang Mei Hans J Baelde Dorien J M Peters Source Type: research
Neuroimmune interplay in kidney health and disease: Role of renal nerves
Auton Neurosci. 2023 Nov 30;250:103133. doi: 10.1016/j.autneu.2023.103133. Online ahead of print.ABSTRACTRenal nerves and their role in physiology and disease have been a topic of increasing interest in the past few decades. Renal inflammation contributes to many cardiorenal disease conditions, including hypertension, chronic kidney disease, and polycystic kidney disease. Much is known about the role of renal sympathetic nerves in physiology - they contribute to the regulation of sodium reabsorption, renin release, and renal vascular resistance. In contrast, far less is known about afferent, or "sensory," renal nerves, whi...
Source: Autonomic Neuroscience - December 7, 2023 Category: Neuroscience Authors: Madeline M Gauthier Sebastien Hayoz Christopher T Banek Source Type: research
Neuroimmune interplay in kidney health and disease: Role of renal nerves
Auton Neurosci. 2023 Nov 30;250:103133. doi: 10.1016/j.autneu.2023.103133. Online ahead of print.ABSTRACTRenal nerves and their role in physiology and disease have been a topic of increasing interest in the past few decades. Renal inflammation contributes to many cardiorenal disease conditions, including hypertension, chronic kidney disease, and polycystic kidney disease. Much is known about the role of renal sympathetic nerves in physiology - they contribute to the regulation of sodium reabsorption, renin release, and renal vascular resistance. In contrast, far less is known about afferent, or "sensory," renal nerves, whi...
Source: Autonomic Neuroscience - December 7, 2023 Category: Neuroscience Authors: Madeline M Gauthier Sebastien Hayoz Christopher T Banek Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
