Suppression of dengue virus replication by the French maritime pine extract Pycnogenol ®
Virus Res. 2023 Oct 11:199244. doi: 10.1016/j.virusres.2023.199244. Online ahead of print.ABSTRACTDengue virus (DENV) is mainly found in the tropics and infects approximately 400 million people annually. However, no clinically available therapeutic agents specific to dengue have been developed. Here, we examined the potential antiviral effects of the French maritime pine extract Pycnogenol® (PYC) against DENV because we previously found that the extract exerts antiviral effects on hepatitis C virus, which belongs to the Flavivirus family. First, we examined the efficacy of PYC against DENV1, 2, 3, and 4 serotypes and dete...
Source: Virus Research - October 13, 2023 Category: Virology Authors: Kazi Anowar Hossain Rupaly Akhter Md Haroon Or Rashid Lipi Akter Masashi Utsunomiya Bouchra Kitab NgweTun Mm Takayuki Hishiki Michinori Kohara Kouichi Morita Kyoko Tsukiyama-Kohara Source Type: research
Vascular polycystin proteins in health and disease
AbstractPKD1 (polycystin 1) and PKD2 (polycystin 2) are expressed in a variety of different cell types, including arterial smooth muscle and endothelial cells. PKD1 is a transmembrane domain protein with a large extracellular N-terminus that is proposed to act as a mechanosensor and receptor. PKD2 is a member of the transient receptor potential (TRP) channel superfamily which is also termed TRPP1. Mutations in the genes which encode PKD1 and PKD2 lead to autosomal polycystic kidney disease (ADPKD). ADPKD is one of the most prevalent monogenic disorders in humans and is associated with extrarenal and vascular complications,...
Source: Microcirculation - October 13, 2023 Category: Research Authors: Ulrich C. Mbiakop,
Jonathan H. Jaggar Tags: REVIEW Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: American Journal of Physiology. Renal Physiology - October 12, 2023 Category: Physiology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: Am J Physiol Renal P... - October 12, 2023 Category: Urology & Nephrology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: American Journal of Physiology. Renal Physiology - October 12, 2023 Category: Physiology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: Am J Physiol Renal P... - October 12, 2023 Category: Urology & Nephrology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: American Journal of Physiology. Renal Physiology - October 12, 2023 Category: Physiology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: American Journal of Physiology. Renal Physiology - October 12, 2023 Category: Physiology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: Am J Physiol Renal P... - October 12, 2023 Category: Urology & Nephrology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: American Journal of Physiology. Renal Physiology - October 12, 2023 Category: Physiology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: Am J Physiol Renal P... - October 12, 2023 Category: Urology & Nephrology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: American Journal of Physiology. Renal Physiology - October 12, 2023 Category: Physiology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Ouabain enhances renal cyst growth in a slowly progressive mouse model of autosomal dominant polycystic kidney disease
Am J Physiol Renal Physiol. 2023 Oct 12. doi: 10.1152/ajprenal.00056.2023. Online ahead of print.ABSTRACTRenal cyst progression in autosomal dominant polycystic kidney disease (ADPKD) is highly dependent on agents circulating in blood. We have previously shown, using different in vitro models, that one of these agents is the hormone ouabain. By binding to Na,K-ATPase (NKA), ouabain triggers a cascade of signal transduction events which enhance ADPKD cyst progression by stimulating cell proliferation, fluid secretion, and dedifferentiation of the renal tubular epithelial cells. Here, we determined the effects of ouabain in ...
Source: Am J Physiol Renal P... - October 12, 2023 Category: Urology & Nephrology Authors: Jordan Trant Gladis Sanchez Jeffrey McDermott Gustavo Blanco Source Type: research
Gse244608 single cell analysis of polycystic kidney disease using human pluripotent stem cell- derived kidney organoids
Contributors : Liu Meng ; Zhang Chao ; Gong Ximing ; Xia YunSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTo reveal the key pathways involved in kidney cystogenesis. We performed single nuclei gene expression and ATAC profiling using kidney organoids from ARPKD patients-iPSCs derived organoids. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
[177Lu]Lu-PSMA-617 Therapy in a Patient with Chronic Kidney Disease
Conclusion: This case suggests that [177Lu]Lu-PSMA–based RLT can be applied successfully and safely to a patient with chronic kidney disease undergoing hemodialysis. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - October 3, 2023 Category: Nuclear Medicine Authors: Mercolli, L., Mingels, C., Manzini, G., Cumming, P., Zeimpekis, K., Xue, S., Alberts, I., Uehlinger, D., Rominger, A., Shi, K., Afshar-Oromieh, A. Tags: Brief Communications Source Type: research
