Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
