GSE223675 Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert modulatory functions on mRNA expression in a cisplatin-induced kidney injury murine model
Contributors : Daniele Christina ; Gretz NobertSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusAcute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer chemotherapeutic agent cisplatin often induces AKI as an adverse drug side effect. Therapies targeted at the reversal of AKI and its potential progression to chronic kidney disease or end-stage renal disease are currently insufficiently effective. Mesenchymal stromal cells (MSC) possess diverse immunomodulatory properties that confer upon...
Source: GEO: Gene Expression Omnibus - January 4, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Role of MCP-1 as an inflammatory biomarker in nephropathy
The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2 (CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of innate immunity and tissue inflammation. It has a notable impact on inflammatory conditions affecting the kidneys. Upon binding to its receptor, MCP-1 can induce lymphocytes and NK cells’ homing, migration, activation, differentiation, and development while promoting monocytes’ and macrophages’ infiltration, thereby facilitating kidney disease-related inflammation. As a biomarker for kidney disease, MCP-1 has made notable advancements in primary k...
Source: Frontiers in Immunology - January 4, 2024 Category: Allergy & Immunology Source Type: research
Outcomes of BRCA pre-implantation genetic testing according to the parental mutation origin: a cohort study
CONCLUSIONS: BRCA PGT-M cycles performed similarly compared to non-BRCA cycles. Inheritance rate and cycle parameters were not affected by the parental origin of the mutation.PMID:38172815 | PMC:PMC10762833 | DOI:10.1186/s12958-023-01180-9 (Source: Reproductive Biology)
Source: Reproductive Biology - January 3, 2024 Category: Reproduction Medicine Authors: Ilana Weizel Tal Shavit Yulia Shuli Chana Adler Lazarovich Rivka Halevi Tal Ben Ari Shira Yaacobi-Artzi Yaakov Bentov Baruch Feldman Anat Hershko Klement Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Metformin reduces decline in the estimated glomerular filtration rate during progression of autosomal dominant polycystic kidney disease: a systematic review and meta-analysis
CONCLUSIONS: Metformin was easily tolerable and safe and substantially reduced the eGFR decline among ADPKD patients. Moreover, although metformin-treated patients were more likely to suffer gastrointestinal adverse events, we observed no discernible difference between the two cohorts.PMID:38164854 | DOI:10.26355/eurrev_202312_34789 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 2, 2024 Category: Drugs & Pharmacology Authors: F Yao S-Q Huang X-S Cheng K Li X-L Jiang Source Type: research
Bicc1: A Potential Biomarker For Heart Failure And Cardio-Renal Syndrome
Patients with polycystic kidney disease (PKD) may develop various forms of cardiomyopathies, which can progress to heart failure (HF) and subsequently result in cardio-renal syndrome (CRS). Bicaudal C homolog 1 (Bicc1) is an evolutionarily conserved RNA-binding protein that has crucial roles in the formation and development of numerous organs, including the heart and kidneys. It is also an essential genetic determinant in autosomal dominant polycystic kidney disease (ADPKD). Prior research has highlighted the significant role of Bicc1 in heart and kidney development as well as in PKD formation. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Chia-Feng Liu, Jennifer Wilcox, Timothy Engelman, Wai Hong Tang Tags: 042 Source Type: research
