Validation of the Mayo Imaging Classification System for Predicting Kidney Outcomes in ADPKD
CONCLUSION: The MIC demonstrated acceptable stability and generally predicted kidney failure and eGFR decline rate. However, there was marked interindividual variability in the rate of disease progression within each class.PMID:38407866 | DOI:10.2215/CJN.0000000000000427 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 26, 2024 Category: Urology & Nephrology Authors: Thomas Bais Paul Geertsema Martine G E Knol Maatje D A van Gastel Robbert J de Haas Esther Meijer Ron T Gansevoort DIPAK Consortium Source Type: research
Emerging mechanistic understanding of cilia function in cellular signalling
Nat Rev Mol Cell Biol. 2024 Feb 16. doi: 10.1038/s41580-023-00698-5. Online ahead of print.ABSTRACTPrimary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell-cell communication using three signalling pathways as ...
Source: Mol Biol Cell - February 17, 2024 Category: Molecular Biology Authors: Keren I Hilgendorf Benjamin R Myers Jeremy F Reiter Source Type: research
Emerging mechanistic understanding of cilia function in cellular signalling
Nat Rev Mol Cell Biol. 2024 Feb 16. doi: 10.1038/s41580-023-00698-5. Online ahead of print.ABSTRACTPrimary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell-cell communication using three signalling pathways as ...
Source: Cancer Control - February 17, 2024 Category: Cancer & Oncology Authors: Keren I Hilgendorf Benjamin R Myers Jeremy F Reiter Source Type: research
Emerging mechanistic understanding of cilia function in cellular signalling
Nat Rev Mol Cell Biol. 2024 Feb 16. doi: 10.1038/s41580-023-00698-5. Online ahead of print.ABSTRACTPrimary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and disease. Cilia generate a unique environment for signal transduction with tight control of protein, lipid and second messenger concentrations within a relatively small compartment, enabling reception, transmission and integration of biological information. In this Review, we discuss how cilia function as signalling hubs in cell-cell communication using three signalling pathways as ...
Source: Mol Biol Cell - February 17, 2024 Category: Molecular Biology Authors: Keren I Hilgendorf Benjamin R Myers Jeremy F Reiter Source Type: research
A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient
AbstractA 50-year-old man who had undergone a living-donor kidney transplant 12 years prior for chronic renal failure due to autosomal dominant polycystic kidney disease contracted coronavirus disease 19 (COVID-19). He had a positive antigen test, mild symptoms, sore throat, and fever of 37.9 ℃. The patient was treated with molnupiravir for 5 days, and the symptoms disapp eared 5 days after onset. However, 10 days after onset, he developed a fever of approximately 37 ℃ and a non-productive cough; 27 days after onset, the patient was hospitalized for anorexia and a worsening respiratory condition. The severe acu...
Source: CEN Case Reports - February 17, 2024 Category: Urology & Nephrology Source Type: research
GSE225495 Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by, kidney macrophages
Conclusion: Chronic dietary protein load-induced renal hypertrophy and accelerated cyst growth in Pkd1KO mice is dependent on both infiltrating and resident M Ф recruitment and subsequent inflammatory response. Early cyst expansion by HP diet, however, is relient on increased delivery of glutamine to kidney epithelial cells, driving downstream metabolic changes prior to inflammatory provocation. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - February 16, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Mortality risk in patients with autosomal dominant polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD). Mortality data specific to patients with ADPKD is currently lacking; thus, the aim of th... (Source: BMC Nephrology)
Source: BMC Nephrology - February 16, 2024 Category: Urology & Nephrology Authors: Deirdre Mladsi, Xiaolei Zhou, Gregory Mader, Myrlene Sanon, Jinyi Wang, Christine Barnett, Cynthia Willey and Stephen Seliger Tags: Research Source Type: research
HYDROchlorothiazide versus placebo to PROTECT polycystic kidney disease patients and improve their quality of life: study protocol and rationale for the HYDRO-PROTECT randomized controlled trial
Autosomal dominant polycystic kidney disease (ADPKD) leads to progressive renal cyst formation and loss of kidney function in most patients. Vasopressin 2 receptor antagonists (V2RA) like tolvaptan are current... (Source: Trials)
Source: Trials - February 14, 2024 Category: General Medicine Authors: Thomas Bais, Esther Meijer, Bart J. Kramers, Priya Vart, Marc Vervloet, Mahdi Salih, Bert Bammens, Nathalie Demoulin, Polina Todorova, Roman-Ulrich M üller, Jan Halbritter, Alexander Paliege, Emilie Cornec-Le Gall, Bertrand Knebelmann, Roser Torra, Alber Tags: Methodology Source Type: research
Factors associated with early-onset intracranial aneurysms in patients with autosomal dominant polycystic kidney disease
CONCLUSION: Kidney dysfunction and family history of intracranial aneurysm or subarachnoid hemorrhage are risk factors for early-onset intracranial aneurysm. Patients aged < 50 years with a family history of intracranial aneurysm or subarachnoid hemorrhage or with CKD stages 4-5 may be at an increased risk of early-onset intracranial aneurysm.PMID:38315279 | DOI:10.1007/s40620-023-01866-8 (Source: Journal of Nephrology)
Source: Journal of Nephrology - February 5, 2024 Category: Urology & Nephrology Authors: Yusuke Ushio Hiroshi Kataoka Hiroyuki Akagawa Masayo Sato Shun Manabe Keiko Kawachi Shiho Makabe Taro Akihisa Momoko Seki Atsuko Teraoka Naomi Iwasa Rie Yoshida Ken Tsuchiya Kosaku Nitta Junichi Hoshino Toshio Mochizuki Source Type: research
Structure of putative epidermal sensory receptors in an acoel flatworm, Praesagittifera naikaiensis
We examined the three-dimensional relationship between epidermal sensory receptors and their innervation in an acoel flatworm,Praesagittifera naikaiensis. The distribution of the sensory receptors was different between the ventral and dorsal sides of worms. The nervous system was mainly composed of a peripheral nerve net, an anterior brain, and three pairs of longitudinal nerve cords. The nerve net was located closer to the body surface than the brain and the nerve cords. The sensory receptors have neural connections with the nerve net in the entire body of worms. We identified five homologs of polycystic kidney disease (P...
Source: Cell and Tissue Research - February 2, 2024 Category: Cytology Source Type: research
Activation of farnesoid X receptor retards expansion of renal collecting duct cells-derived cysts via inhibition of CFTR-mediated Cl < sup > - < /sup > secretion
This study shows that FXR activation inhibits Cl- secretion in renal cells via inhibition of CFTR expression and retards renal cyst formation and growth. The discoveries point to a physiological role of FXR in the regulation of CFTR and a potential therapeutic application in polycystic kidney disease treatment.PMID:38299213 | DOI:10.1152/ajprenal.00363.2023 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 1, 2024 Category: Urology & Nephrology Authors: Nipitpon Srimai Kanlayanee Tonum Sunhapas Soodvilai Source Type: research
Activation of farnesoid X receptor retards expansion of renal collecting duct cells-derived cysts via inhibition of CFTR-mediated Cl < sup > - < /sup > secretion
This study shows that FXR activation inhibits Cl- secretion in renal cells via inhibition of CFTR expression and retards renal cyst formation and growth. The discoveries point to a physiological role of FXR in the regulation of CFTR and a potential therapeutic application in polycystic kidney disease treatment.PMID:38299213 | DOI:10.1152/ajprenal.00363.2023 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - February 1, 2024 Category: Physiology Authors: Nipitpon Srimai Kanlayanee Tonum Sunhapas Soodvilai Source Type: research
Caroli ’s disease and pregnancy - Do we expect the unexpected?
Caroli disease is a rare congenital disorder with multiple segmental cystic dilatation of intrahepatic biliary ducts with no periportal fibrosis and is assciated with recurrent episodes of cholangitis. Carolis syndrome is associated with periportal fibrosis and consequently with portal hypertension, oesophageal varices and splenomegaly. Incidence of carolis disease is 1 in 1,000,000. Associations with renal diseases like Autosomal recessive polycystic kidney disease, medullary cysts and nephronopthisis. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Dhavashree Veeramani, B. Sivasubramaniam, Priyadharshini Swaminathan, Arthi Chandrasekar, Akila Thirugnanam Source Type: research
Incidental Genetic Finding in a Fetus
A 37-year-old woman presented with suspected polycystic kidney detected on routine fetal ultrasonography, and an incidental finding of a heterozygous c.501-2 A<G sequence variant in the RB1 gene was noted. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - February 1, 2024 Category: Opthalmology Source Type: research
