A Combination of ß-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Am J Physiol Renal Physiol. 2023 Dec 14. doi: 10.1152/ajprenal.00205.2023. Online ahead of print.ABSTRACTOur research has shown that interventions producing a state of ketosis are highly effective in rat, mouse, and cat models of polycystic kidney disease (PKD), preventing and partially reversing cyst growth and disease progression. The ketone ß-hydroxybutyrate (BHB) appears to underlie this effect. Additionally, we have demonstrated that naturally formed microcrystals within kidney tubules trigger a renoprotective response that facilitates tubular obstruction clearance in healthy animals but, alternatively, leads to cyst...
Source: Am J Physiol Renal P... - December 14, 2023 Category: Urology & Nephrology Authors: Jacob A Torres Nickolas Holznecht David A Asplund Tselmeg Amarlkhagva Bradley Kroes Juliette Rebello Shagun Agrawal Thomas Weimbs Source Type: research
Deep learning-based automated kidney and cyst segmentation of autosomal dominant polycystic kidney disease using single vs. multi-institutional data
This study aimed to investigate if a deep learning model trained with a single institution's data has comparable accuracy to that trained with multi-institutional data for segmenting kidney and cyst regions in magnetic resonance (MR) images of patients affected by autosomal dominant polycystic kidney disease (ADPKD). (Source: Clinical Imaging)
Source: Clinical Imaging - December 11, 2023 Category: Radiology Authors: Emma K. Schmidt, Chetana Krishnan, Ezinwanne Onuoha, Adriana V. Gregory, Timothy L. Kline, Michal Mrug, Carlos Cardenas, Harrison Kim, Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) investigators Tags: Body Imaging Source Type: research
Transcriptomic profiling of polycystic kidney disease identifies paracrine factors in the early cyst microenvironment
Biochim Biophys Acta Mol Basis Dis. 2023 Dec 7:166987. doi: 10.1016/j.bbadis.2023.166987. Online ahead of print.ABSTRACTInitial cysts that are formed upon Pkd1 loss in mice impose persistent stress on surrounding tissue and trigger a cystic snowball effect, in which local aberrant PKD-related signaling increases the likelihood of new cyst formation, ultimately leading to accelerated disease progression. Although many pathways have been associated with PKD progression, the knowledge of early changes near initial cysts is limited. To perform an unbiased analysis of transcriptomic alterations in the cyst microenvironment, mic...
Source: Biochimica et Biophysica Acta - December 9, 2023 Category: Biochemistry Authors: Sevtap A Yasinoglu Thomas B Kuipers Ernst Suidgeest Louise van der Weerd Hailiang Mei Hans J Baelde Dorien J M Peters Source Type: research
Neuroimmune interplay in kidney health and disease: Role of renal nerves
Auton Neurosci. 2023 Nov 30;250:103133. doi: 10.1016/j.autneu.2023.103133. Online ahead of print.ABSTRACTRenal nerves and their role in physiology and disease have been a topic of increasing interest in the past few decades. Renal inflammation contributes to many cardiorenal disease conditions, including hypertension, chronic kidney disease, and polycystic kidney disease. Much is known about the role of renal sympathetic nerves in physiology - they contribute to the regulation of sodium reabsorption, renin release, and renal vascular resistance. In contrast, far less is known about afferent, or "sensory," renal nerves, whi...
Source: Autonomic Neuroscience - December 7, 2023 Category: Neuroscience Authors: Madeline M Gauthier Sebastien Hayoz Christopher T Banek Source Type: research
Neuroimmune interplay in kidney health and disease: Role of renal nerves
Auton Neurosci. 2023 Nov 30;250:103133. doi: 10.1016/j.autneu.2023.103133. Online ahead of print.ABSTRACTRenal nerves and their role in physiology and disease have been a topic of increasing interest in the past few decades. Renal inflammation contributes to many cardiorenal disease conditions, including hypertension, chronic kidney disease, and polycystic kidney disease. Much is known about the role of renal sympathetic nerves in physiology - they contribute to the regulation of sodium reabsorption, renin release, and renal vascular resistance. In contrast, far less is known about afferent, or "sensory," renal nerves, whi...
Source: Autonomic Neuroscience - December 7, 2023 Category: Neuroscience Authors: Madeline M Gauthier Sebastien Hayoz Christopher T Banek Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
Functions of the primary cilium in the kidney and its connection with renal diseases
Curr Top Dev Biol. 2023;155:39-94. doi: 10.1016/bs.ctdb.2023.07.001. Epub 2023 Aug 16.ABSTRACTThe nonmotile primary cilium is a sensory structure found on most mammalian cell types that integrates multiple signaling pathways involved in tissue development and postnatal function. As such, mutations disrupting cilia activities cause a group of disorders referred to as ciliopathies. These disorders exhibit a wide spectrum of phenotypes impacting nearly every tissue. In the kidney, primary cilia dysfunction caused by mutations in polycystin 1 (Pkd1), polycystin 2 (Pkd2), or polycystic kidney and hepatic disease 1 (Pkhd1), resu...
Source: Current Topics in Developmental Biology - December 3, 2023 Category: Biology Authors: Kelsey R Clearman Courtney J Haycraft Mandy J Croyle James F Collawn Bradley K Yoder Source Type: research
