Accelerated MEN 2A in Homozygous RET Carriers in the Context of Consanguinity
CONCLUSION: These results, limited in scope and size and modulated by extent of consanguinity, are consistent with moderate dose-response effects accelerating MEN2A development.PMID:38465999 | DOI:10.1093/ejendo/lvae025 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 11, 2024 Category: Endocrinology Authors: Andreas Machens Henning Dralle Source Type: research
Comparison of clinical efficacy and safety between robotic-assisted and laparoscopic adrenalectomy for pheochromocytoma: a systematic review and meta-analysis
AbstractTo compare the clinical efficacy and safety of robot-assisted adrenalectomy (RA) and laparoscopic adrenalectomy (LA) for pheochromocytoma (PHEO). We conducted a comprehensive search of PubMed, the Cochrane Library, and Embase databases for studies comparing RA and LA treatment for PHEO, covering the period from database inception to January 1, 2024. Two researchers will independently screen literature and extract data, followed by meta-analysis using Review Manager 5.3 software. Six studies with 658 patients were included in the analysis. There were no significant differences in operation time [MD = −8.03, 9...
Source: Journal of Robotic Surgery - March 11, 2024 Category: Surgery Source Type: research
FIRSTMAPPP prospectively charts the efficacy of sunitinib for phaeochromocytoma and paraganglioma
Nature Reviews Clinical Oncology, Published online: 08 March 2024; doi:10.1038/s41571-024-00880-4FIRSTMAPPP prospectively charts the efficacy of sunitinib for phaeochromocytoma and paraganglioma (Source: Nature Reviews Clinical Oncology)
Source: Nature Reviews Clinical Oncology - March 8, 2024 Category: Cancer & Oncology Authors: David Killock Source Type: research
Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism
In this study, we used ultra-performance liquid chromatography (UPLC)/quadrupole time-of-flight mass spectrometry (Q-TOF MS) analysis to identify and measure the perioperative differential metabolites in the plasma of adrenal pheochromocytoma patients. We identified differentially expressed genes by comparing the transcriptomic data of pheochromocytoma with the normal adrenal medulla. Through conducting two steps of metabolomics analysis, we identified 111 differential metabolites between the healthy group and the patient group, among which 53 metabolites were validated. By integrating the information of differential metab...
Source: J Zhejiang Univ Sci ... - March 6, 2024 Category: Science Authors: Chong Lai Qingling Yang Yunuo Zhang Renjie Gong Majie Wang Jiankang Li Maode Lai Qingrong Sun Source Type: research
Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism
In this study, we used ultra-performance liquid chromatography (UPLC)/quadrupole time-of-flight mass spectrometry (Q-TOF MS) analysis to identify and measure the perioperative differential metabolites in the plasma of adrenal pheochromocytoma patients. We identified differentially expressed genes by comparing the transcriptomic data of pheochromocytoma with the normal adrenal medulla. Through conducting two steps of metabolomics analysis, we identified 111 differential metabolites between the healthy group and the patient group, among which 53 metabolites were validated. By integrating the information of differential metab...
Source: J Zhejiang Univ Sci ... - March 6, 2024 Category: Science Authors: Chong Lai Qingling Yang Yunuo Zhang Renjie Gong Majie Wang Jiankang Li Maode Lai Qingrong Sun Source Type: research
Pediatric malignant pheochromocytoma with atypical presentation as vision changes, lung metastasis, and recurrence: a case report
ConclusionAlthough there are well-recognized classic clinical manifestations associated with pheochromocytoma, atypical presentation, such as vision changes in children, should be considered. In addition, malignant pheochromocytoma children with a high Pheochromocytoma of the Adrenal Gland Scaled Score andsuccinate dehydrogenase complex iron sulfur subunitB mutation require a long-term follow-up or even unplanned surgery because of the higher risk of recurrence. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 5, 2024 Category: General Medicine Source Type: research
HIF1A transcriptional regulation of COX4I2 impacts angiogenesis in pheochromocytoma
CONCLUSION: COX4I2 is overexpressed in highly vascular PCC and contributes to angiogenesis in fibroblasts. Mechanistically, HIF1A transcriptional regulation enhances COX4I2 and its effects on angiogenesis in PCC. COX4I2 might serve as a vascular marker and represent a potential target for vascular therapy.PMID:38422899 | DOI:10.1016/j.bbrc.2024.149638 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - February 29, 2024 Category: Biochemistry Authors: Xiuci Li Ran Zhuo Yongxin Mao Chen Fang Jun Dai Lei Ye Chenghe Wang Fukang Sun Source Type: research
HIF1A transcriptional regulation of COX4I2 impacts angiogenesis in pheochromocytoma
CONCLUSION: COX4I2 is overexpressed in highly vascular PCC and contributes to angiogenesis in fibroblasts. Mechanistically, HIF1A transcriptional regulation enhances COX4I2 and its effects on angiogenesis in PCC. COX4I2 might serve as a vascular marker and represent a potential target for vascular therapy.PMID:38422899 | DOI:10.1016/j.bbrc.2024.149638 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - February 29, 2024 Category: Biochemistry Authors: Xiuci Li Ran Zhuo Yongxin Mao Chen Fang Jun Dai Lei Ye Chenghe Wang Fukang Sun Source Type: research
Nuclear medicine practice in Japan: a report of the ninth nationwide survey in 2022
AbstractSubcommittee on Survey of Nuclear Medicine Practice in Japan has performed a nationwide survey of nuclear medicine practice every 5 years since 1982 to survey contemporary nuclear medicine practice and its changes over the years. The subcommittee sent questionnaires, including the number and category of examinations as well as the kind of the radiopharmaceuticals during the 30 days of June 2022 to all nuclear medicine institu tes in Japan. The total numbers of them for the year 2022 were estimated depends on the 1-month data. A total of 1095 institutes responded to the survey, including 364 positron emission tom...
Source: Annals of Nuclear Medicine - February 29, 2024 Category: Nuclear Medicine Source Type: research
Advanced Hollow Cathode Discharge Plasma Treatment of Unique Bilayered Fibrous Nerve Guidance Conduits for Enhanced/Oriented Neurite Outgrowth
Biomacromolecules. 2024 Feb 27. doi: 10.1021/acs.biomac.3c00976. Online ahead of print.ABSTRACTDespite all recent progresses in nerve tissue engineering, critical-sized nerve defects are still extremely challenging to repair. Therefore, this study targets the bridging of critical nerve defects and promoting an oriented neuronal outgrowth by engineering innovative nerve guidance conduits (NGCs) synergistically possessing exclusive topographical, chemical, and mechanical cues. To do so, a mechanically adequate mixture of polycaprolactone (PCL) and polylactic-co-glycolic acid (PLGA) was first carefully selected as base materi...
Source: Biomacromolecules - February 27, 2024 Category: Biochemistry Authors: Sheida Aliakbarshirazi Rouba Ghobeira Mahtab Asadian Mehrnoush Narimisa Anton Nikiforov Ives De Baere Wim Van Paepegem Nathalie De Geyter Heidi Declercq Rino Morent Source Type: research
Advanced Hollow Cathode Discharge Plasma Treatment of Unique Bilayered Fibrous Nerve Guidance Conduits for Enhanced/Oriented Neurite Outgrowth
Biomacromolecules. 2024 Feb 27. doi: 10.1021/acs.biomac.3c00976. Online ahead of print.ABSTRACTDespite all recent progresses in nerve tissue engineering, critical-sized nerve defects are still extremely challenging to repair. Therefore, this study targets the bridging of critical nerve defects and promoting an oriented neuronal outgrowth by engineering innovative nerve guidance conduits (NGCs) synergistically possessing exclusive topographical, chemical, and mechanical cues. To do so, a mechanically adequate mixture of polycaprolactone (PCL) and polylactic-co-glycolic acid (PLGA) was first carefully selected as base materi...
Source: Biomacromolecules - February 27, 2024 Category: Biochemistry Authors: Sheida Aliakbarshirazi Rouba Ghobeira Mahtab Asadian Mehrnoush Narimisa Anton Nikiforov Ives De Baere Wim Van Paepegem Nathalie De Geyter Heidi Declercq Rino Morent Source Type: research
Validation of the modified CT criteria for identifying non-adenomas
ConclusionThe utilization of modified criteria has the potential to identify additional non-adenomas that would otherwise be misdiagnosed as adenomas using conventional criteria alone.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - February 27, 2024 Category: Radiology Source Type: research
Cancers, Vol. 16, Pages 947: Advancing Precision Oncology in Hereditary Paraganglioma-Pheochromocytoma Syndromes: Integrated Interpretation and Data Sharing of the Germline and Tumor Genomes
INT²GRATE Oncology Consortium
Standard methods of variant assessment in hereditary cancer susceptibility genes are limited by the lack of availability of key supporting evidence. In cancer, information derived from tumors can serve as a useful source in delineating the tumor behavior and the role of germline variants in tumor progression. We have previously demonstrated the value of integrating tumor and germline findings to comprehensively assess germline variants in hereditary cancer syndromes. Building on this work, herein, we present the development and application of the INT²GRATE|HPPGL platform. IN...
Source: Cancers - February 26, 2024 Category: Cancer & Oncology Authors: Rana Koeller Walker Unal Levine Chittenden Isidro Hayes Manam Buehler Manning Barletta Hornick Garber Ghazani INT ²GRATE Oncology Consortium Tags: Article Source Type: research
BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
CONCLUSION: BMSC-Exos could attenuate ALP dysfunction by restoring lysosomal function after CIRI by inhibiting mTOR and then promoting TFEB nucleus translocation.PMID:38403042 | DOI:10.1016/j.expneurol.2024.114726 (Source: Experimental Neurology)
Source: Experimental Neurology - February 25, 2024 Category: Neurology Authors: Haining Liu Chen Li Xiaofeng Zhang Hui Chen Qi Zhang Yuting Zeng Shuqi Zheng Jihua Zou Yijin Zhao Xiaoyan Zheng Guozhi Huang Qing Zeng Source Type: research
