BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury
CONCLUSION: BMSC-Exos could attenuate ALP dysfunction by restoring lysosomal function after CIRI by inhibiting mTOR and then promoting TFEB nucleus translocation.PMID:38403042 | DOI:10.1016/j.expneurol.2024.114726 (Source: Experimental Neurology)
Source: Experimental Neurology - February 25, 2024 Category: Neurology Authors: Haining Liu Chen Li Xiaofeng Zhang Hui Chen Qi Zhang Yuting Zeng Shuqi Zheng Jihua Zou Yijin Zhao Xiaoyan Zheng Guozhi Huang Qing Zeng Source Type: research
Hybrid pharmacophore design and synthesis of donepezil-inspired aurone derivative salts as multifunctional acetylcholinesterase inhibitors
The objective of this study was to design and synthesize valuable agents derived from flavonoids for relieving the symptoms of AD. A variety of flavonoid derivative salts incorporating benzylpyridinium units were synthesized and several of them remarkedly inhibited acetylcholinesterase (AChE) activity in vitro. Additionally, aurone derivative salts protected against cell death resulting from t-BHP exposure in rat pheochromocytoma PC12 cells and slightly promoted neurite outgrowth. Furthermore, they potently suppressed the aggregation of amyloid-β (Aβ1-42). Our findings highlight the effectiveness of donepezil-inspired au...
Source: Bioorganic Chemistry - February 24, 2024 Category: Chemistry Authors: Rei Funahashi Fumiaki Matsuura Masayuki Ninomiya Sayo Okabe Shigeo Takashima Kaori Tanaka Atsuyoshi Nishina Mamoru Koketsu Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: Endocrine Reviews - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
The Immune Landscape of Pheochromocytoma and Paraganglioma: Current Advances and Perspectives
Endocr Rev. 2024 Feb 20:bnae005. doi: 10.1210/endrev/bnae005. Online ahead of print.ABSTRACTPheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors derived from neural crest cells from adrenal medullary chromaffin tissues or extra-adrenal paraganglia, respectively. Although the current treatment for PPGLs is surgery, optimal treatment options for advanced and metastatic cases have been limited. Hence, understanding the role of the immune system in PPGL tumorigenesis can provide essential knowledge for the development of better therapeutic and tumor management strategies, especially for those with advanc...
Source: ENDOCR REV - February 20, 2024 Category: Endocrinology Authors: Ondrej Uher Katerina Hadrava Vanova David Taieb Bruna Calsina Mercedes Robledo Roderick Clifton-Bligh Karel Pacak Source Type: research
