Safety and efficacy of multiple-dose versus single-dose MIBG therapy in patients with refractory pheochromocytoma and paraganglioma: a single-center retrospective analysis
ConclusionIn I-131 MIBG therapy for PPGLs, multiple administrations significantly increased only Grade 1 or 2 lymphopenia and leukopenia compared to single administration. (Source: Annals of Nuclear Medicine)
Source: Annals of Nuclear Medicine - April 24, 2024 Category: Nuclear Medicine Source Type: research
Lycium barbarum polysaccharides attenuate nonylphenol and octylphenol-induced oxidative stress and neurotransmitter disorders in PC-12 cells
This study aims to explore the cytotoxicity of combined NP and OP exposure and evaluate the potential of Lycium barbarum polysaccharides (LBP) in mitigating the aforementioned toxicity. In present study, LBP (62.5, 125 and 250µg/mL) were applied to intervene rat adrenal pheochromocytoma (PC-12) cells treated with combined NP and OP (NP: OP = 4:1, w/w; 1, 2, 4 and 8µg/mL). The results showed that NP and OP induced oxidative stress, disrupted the 5-hydroxytryptamine (5-HT) and cholinergic systems in PC-12 cells. Additionally, they activated the p38 protein kinase (p38) and suppressed the expression of silent information re...
Source: Toxicology - April 20, 2024 Category: Toxicology Authors: Linjing Xu Huan Liu Yifeng Rang Lizi Zhou Xukai Wang Yinhuan Li Chunhong Liu Source Type: research
High-Specific-Activity 131I-MIBG for the Treatment of Advanced Pheochromocytoma and Paraganglioma
CONCLUSIONS: HSA-131I-MIBG is associated with a high DCR in patients with MPPGL, regardless of underlying genetic mutation.PMID:38630996 | DOI:10.1097/RLU.0000000000005184 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ruaa Al-Ward Vania Balderrama Brondani Sahar Sawani Cheryl L Potter Guofan Xu Steven G Waguespack Jeena Varghese Mouhammed Amir Habra Yang Lu Camilo Jimenez Source Type: research
Diagnostic performance of [68Ga]DOTATATE PET/CT, [18F]FDG PET/CT, MRI of the spine, and whole-body diagnostic CT and MRI in the detection of spinal bone metastases associated with pheochromocytoma and paraganglioma
Conclusions[68Ga]DOTATATE PET/CT should be the modality of choice in PPGL-related spinal bone metastases due to its superior detection rate.Clinical relevance statementIn a prospective study of 43 pheochromocytoma/paraganglioma participants with spinal bone metastases, [68Ga]DOTATATE PET/CT had a superior per-lesion detection rate of 98.7% (377/382), compared to [18F]FDG PET/CT (p < 0.001), MRI of the spine (p < 0.001), whole-body CT (p < 0.001), and whole-body MRI (p < 0.001).Graphical abstractKey Points• Data regarding head-to-head comparison between functional and anatomic imaging modal...
Source: European Radiology - April 16, 2024 Category: Radiology Source Type: research
Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
CONCLUSION: Our study provides a new perspective on the pathogenic mechanisms of VaD and potential avenues for therapeutic intervention. The results highlight the role of ADRA1D in modulating cellular responses to OGD and VaD, suggesting its potential as a target for VaD treatment.PMID:38622006 | DOI:10.62641/aep.v52i2.1601 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Yuanhua Wu Jing Cai Bo Pang Liping Cao Qiankun He Qiansong He Anbang Zhang Source Type: research
Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
CONCLUSION: Our study provides a new perspective on the pathogenic mechanisms of VaD and potential avenues for therapeutic intervention. The results highlight the role of ADRA1D in modulating cellular responses to OGD and VaD, suggesting its potential as a target for VaD treatment.PMID:38622006 | DOI:10.62641/aep.v52i2.1601 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Yuanhua Wu Jing Cai Bo Pang Liping Cao Qiankun He Qiansong He Anbang Zhang Source Type: research
Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
CONCLUSION: Our study provides a new perspective on the pathogenic mechanisms of VaD and potential avenues for therapeutic intervention. The results highlight the role of ADRA1D in modulating cellular responses to OGD and VaD, suggesting its potential as a target for VaD treatment.PMID:38622006 | PMC:PMC11015743 | DOI:10.62641/aep.v52i2.1601 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Yuanhua Wu Jing Cai Bo Pang Liping Cao Qiankun He Qiansong He Anbang Zhang Source Type: research
Bioinformatic Identification of Signaling Pathways and Hub Genes in Vascular Dementia
CONCLUSION: Our study provides a new perspective on the pathogenic mechanisms of VaD and potential avenues for therapeutic intervention. The results highlight the role of ADRA1D in modulating cellular responses to OGD and VaD, suggesting its potential as a target for VaD treatment.PMID:38622006 | PMC:PMC11015743 | DOI:10.62641/aep.v52i2.1601 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - April 15, 2024 Category: Psychiatry Authors: Yuanhua Wu Jing Cai Bo Pang Liping Cao Qiankun He Qiansong He Anbang Zhang Source Type: research
Paraaortic Extra-Adrenal Paraganglioma: Challenging Robotic Resection
CONCLUSIONS: Robotic-assisted resection can be safe and effective for retroperitoneal malignant paragangliomas. However, management extends beyond surgery and requires cascade genetic testing to address familial risks. Because of the high probability of cancer associated with SDHB mutation, lifelong patient surveillance is imperative.PMID:38615151 | DOI:10.1245/s10434-024-15267-z (Source: Ann Oncol)
Source: Ann Oncol - April 13, 2024 Category: Cancer & Oncology Authors: Andrei Nikiforchin Ekaterina Baron Jessica A Wernberg Rohit Sharma Source Type: research
Opposing effects of cannabidiol in patient-derived neuroendocrine tumor, pheochromocytoma/paraganglioma primary cultures
CONCLUSIONS: We suggest a potential novel treatment option for some NETs/PPGLs, but also provide evidence for caution when applying cannabinoids as supportive therapy for pain or appetite management to cancer patients, and possibly as health supplements.PMID:38605427 | DOI:10.1210/clinem/dgae241 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Katharina Wang Laura Schober Alessa Fischer Nicole Bechmann Julian Maurer Lea Peischer Astrid Reul Constanze Hantel Martin Reincke Felix Beuschlein Mercedes Robledo Hermine Mohr Natalia S Pellegata Katharina Schilbach Thomas Kn ösel Matthias Ilmer Martin Source Type: research
Outcomes of SDHB pathogenic variant carriers: A systematic review and meta-analysis
CONCLUSION: Penetrance for PPGL in SDHB PV carriers increases linearly with age. Affected carriers are at risk of developing and dying from metastatic disease, or of developing second tumors. Lifelong surveillance is appropriate.PMID:38605204 | DOI:10.1210/clinem/dgae233 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2024 Category: Endocrinology Authors: Dahlia F Davidoff Richard De Abreu Lourenco Venessa H M Tsang Diana E Benn Roderick J Clifton-Bligh Source Type: research
Cardiomyopathy caused by a pheochromocytoma crisis in a 66-year-old woman
CMAJ. 2024 Apr 7;196(13):E441-E444. doi: 10.1503/cmaj.231575.NO ABSTRACTPMID:38589027 | DOI:10.1503/cmaj.231575 (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - April 8, 2024 Category: General Medicine Authors: Yaanu Jeyakumar Phillip Segal Alexander Kumachev Source Type: research
Thorough examination of the potential biological implications of the cuproptosis-related gene LIPT2 in the prognosis and immunotherapy in pan-cancer
CONCLUSION: Overall, our study highlights LIPT2 as a versatile player in cancer, influencing diverse aspects from molecular processes to clinical outcomes across different cancer types.PMID:38586090 | PMC:PMC10994786 | DOI:10.62347/QNNE5428 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Mi Luo Abdul Rehman Soha Haque Saba Izhar Fauzia Perveen Muhammad Haris Mostafa A Abdel-Maksoud Ibrahim A Saleh Naser Zomot Abdul Malik Abdulaziz Alamri Ahmad S Kodous Mohammed Aufy Mohamed Y Zaky Muhammad Zaeem Yasir Hameed Junwei Li Source Type: research
Cardiomyopathy caused by a pheochromocytoma crisis in a 66-year-old woman
CMAJ. 2024 Apr 7;196(13):E441-E444. doi: 10.1503/cmaj.231575.NO ABSTRACTPMID:38589027 | DOI:10.1503/cmaj.231575 (Source: cmaj)
Source: cmaj - April 8, 2024 Category: General Medicine Authors: Yaanu Jeyakumar Phillip Segal Alexander Kumachev Source Type: research
Cardiomyopathy caused by a pheochromocytoma crisis in a 66-year-old woman
CMAJ. 2024 Apr 7;196(13):E441-E444. doi: 10.1503/cmaj.231575.NO ABSTRACTPMID:38589027 | DOI:10.1503/cmaj.231575 (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - April 8, 2024 Category: General Medicine Authors: Yaanu Jeyakumar Phillip Segal Alexander Kumachev Source Type: research
